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公开(公告)号:US11149049B2
公开(公告)日:2021-10-19
申请号:US16648405
申请日:2018-09-18
发明人: Leonid Beigelman , Jerome Deval , Marija Prhavc
摘要: Disclosed herein are compounds of the Formula (I) and pharmaceutically acceptable salts thereof: (I) where the variables in Formula (I) are described herein. Methods of synthesizing such compounds and methods of using them to treat diseases and/or conditions such as a Picornaviridae, Flaviviridae, Filoviridae, Pneumoviridae and/or Coronaviridae viral infections are also disclosed.
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公开(公告)号:US11021509B2
公开(公告)日:2021-06-01
申请号:US16528414
申请日:2019-07-31
IPC分类号: C07H19/06 , C07H19/207 , C07H19/16 , A61P31/16 , A61K45/06 , C07D405/04 , C07D405/14 , C07D473/18 , C07D473/34 , C07D487/04 , C07D493/04 , C07H19/00 , C07H19/14 , C12N9/12 , C07H19/10 , C07H19/12 , C07H19/20
摘要: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号:USRE48171E1
公开(公告)日:2020-08-25
申请号:US16130971
申请日:2018-09-13
IPC分类号: C07H19/06 , A61K31/708 , A61K31/706 , C07H19/20 , A61K31/7076 , C07H19/12 , C07H19/207 , A61K31/7068 , C07H19/16 , A61K31/7072 , C07H19/10
摘要: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
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