公开(公告)号：US10730950B2

公开(公告)日：2020-08-04

申请号：US15453451

申请日：2017-03-08

Applicant: Janssen Biotech, Inc.

Inventor： Cam Holland ,  John Kehoe ,  Linda Snyder ,  Alejandro Sepulveda ,  Daniel Villarreal

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P31/20 ,  A61P31/04 ,  A61K39/08 ,  A61K39/12 ,  A61K39/39

Abstract: Provided herein are antibodies that specifically bind to GITR. Also described are related polynucleotides capable of encoding the provided GITR-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to enhance an immune response in a subject against cancer.

公开(公告)号：US20170260282A1

公开(公告)日：2017-09-14

申请号：US15453451

申请日：2017-03-08

Applicant: Janssen Biotech, Inc.

Inventor： Cam Holland ,  John Kehoe ,  Linda Snyder ,  Alejandro Sepulveda ,  Daniel Villareal

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  A61K45/06

CPC classification number: C07K16/2878 ,  A61K39/0011 ,  A61K39/08 ,  A61K39/12 ,  A61K39/39 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  A61K2039/58 ,  A61K2039/585 ,  A61P31/04 ,  A61P31/20 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2866 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/92 ,  C12N2710/16134 ,  A61K2300/00

Abstract: Provided herein are antibodies that specifically bind to GITR. Also described are related polynucleotides capable of encoding the provided GITR-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to enhance an immune response in a subject against cancer.