公开(公告)号：US12018289B2

公开(公告)日：2024-06-25

申请号：US17097458

申请日：2020-11-13

Applicant: Janssen Biotech, Inc.

Inventor： Ricardo Attar ,  Jason Dehart ,  Selina Khan ,  Vinod Krishna ,  Jenifer Lum ,  Christian Maine ,  Barbara Sanders ,  Manuel Alejandro Sepulveda ,  Patrick Wilkinson ,  Roland Zahn

IPC: C12N7/00 ,  A61K39/00 ,  A61K45/06 ,  C12N15/86

CPC classification number: C12N7/00 ,  A61K45/06 ,  C12N15/86 ,  A61K2039/505 ,  C12N2750/14111

Abstract: Provided are vaccines, polypeptides and polynucleotides based on mutant CALR and JAK2 sequences, vectors, host cells, viruses, and methods of making and using them. The disclosure also provides methods of inducing an immune response and methods of treating, preventing, reducing a risk of onset or delaying the onset of a clinical condition characterized by an expression of JAK2V617F or CALR exon 9 mutant, or both JAK2V617F and CALR exon 9 mutant, wherein the method comprises a plurality of administrations of any of the compositions comprising polynucleotides, polypeptides or vectors disclosed herein.