-
公开(公告)号：US12018289B2
公开(公告)日：2024-06-25
申请号：US17097458
申请日：2020-11-13
Applicant: Janssen Biotech, Inc.
Inventor： Ricardo Attar , Jason Dehart , Selina Khan , Vinod Krishna , Jenifer Lum , Christian Maine , Barbara Sanders , Manuel Alejandro Sepulveda , Patrick Wilkinson , Roland Zahn
CPC classification number: C12N7/00 , A61K45/06 , C12N15/86 , A61K2039/505 , C12N2750/14111
Abstract: Provided are vaccines, polypeptides and polynucleotides based on mutant CALR and JAK2 sequences, vectors, host cells, viruses, and methods of making and using them. The disclosure also provides methods of inducing an immune response and methods of treating, preventing, reducing a risk of onset or delaying the onset of a clinical condition characterized by an expression of JAK2V617F or CALR exon 9 mutant, or both JAK2V617F and CALR exon 9 mutant, wherein the method comprises a plurality of administrations of any of the compositions comprising polynucleotides, polypeptides or vectors disclosed herein.
-
公开(公告)号：US20230035403A1
公开(公告)日：2023-02-02
申请号：US17366769
申请日：2021-07-02
Applicant: Janssen Biotech, Inc.
Inventor： Denis A. Smirnov , Yashoda Rani Rajpurohit , Vipul Bhargava , Patrick Wilkinson , Kai Fu , Manuel Alejandro Sepulveda
IPC: G01N33/50 , G01N33/574 , C12Q1/686 , C12Q1/6806 , A61K35/768 , C12N7/00
Abstract: Disclosed herein are methods of diagnosing and treating a subject with prostate cancer, as well as methods of monitoring the responsiveness of a subject having prostate cancer to a therapeutic agent.
-
公开(公告)号：US20230024133A1
公开(公告)日：2023-01-26
申请号：US17366545
申请日：2021-07-02
Applicant: Janssen Biotech, Inc.
Inventor： Jason Lee DeHart , Vipul Bhargava , Patrick Wilkinson , Manuel Alejandro Sepulveda
Abstract: Disclosed herein are self-replicating RNA molecules encoding prostate neoantigens, vaccines, and method of treating and preventing prostate cancer using the self-replicating RNA molecules and vaccines.
-
-
Search Results
3
records
(took 0.014 seconds)
