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公开(公告)号：US20240254161A1
公开(公告)日：2024-08-01
申请号：US18583364
申请日：2024-02-21
Applicant: Janssen Biotech, Inc.
Inventor： Vipul Bhargava , Vinod Krishna , David J. Pocalyko , Pegah Safabakhsh , Manuel Alejandro Sepulveda
CPC classification number: C07K2/00 , A61K45/06 , C07K1/107 , C12N15/86 , A61K38/00 , C12N2710/10041 , C12N2710/24041
Abstract: The disclosure relates to ovarian cancer neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the ovarian cancer neoantigens, and methods of making and using them.
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公开(公告)号：US20230029453A1
公开(公告)日：2023-02-02
申请号：US17366946
申请日：2021-07-02
Applicant: Janssen Biotech, Inc.
Inventor： Jason Lee DeHart , Vipul Bhargava , Manuel Alejandro Sepulveda
Abstract: Disclosed herein are self-replicating RNA molecules encoding prostate neoantigens, vaccines, and methods of treating and preventing prostate cancer.
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公开(公告)号：US20230285548A1
公开(公告)日：2023-09-14
申请号：US18080639
申请日：2022-12-13
Applicant: Janssen Biotech, Inc.
Inventor： Patrick WILKINSON , Manuel Alejandro Sepulveda , Charles George Drake , Derick Siegel
IPC: A61K39/235 , A61K39/285 , A61K39/395 , A61K45/06
CPC classification number: A61K39/235 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K2039/505
Abstract: Disclosed herein are methods of treating or preventing a myeloproliferative disease, a cancer, or a cardiovascular disease, and methods of inducing an immune response, in a subject having a JAK2V617F substitution and/or a CALR exon 9 mutation.
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公开(公告)号：US12295997B2
公开(公告)日：2025-05-13
申请号：US17366946
申请日：2021-07-02
Applicant: Janssen Biotech, Inc.
Inventor： Jason Lee DeHart , Vipul Bhargava , Manuel Alejandro Sepulveda
Abstract: Disclosed herein are self-replicating RNA molecules encoding prostate neoantigens, vaccines, and methods of treating and preventing prostate cancer.
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公开(公告)号：US20210261636A1
公开(公告)日：2021-08-26
申请号：US17174590
申请日：2021-02-12
Applicant: Janssen Biotech, Inc.
Inventor： Vipul BHARGAVA , Vinod Krishna , Jaymala Patel , David J. Pocalyko , Yashoda Rani Rajpurohit , Pegah Safabakhsh , Manuel Alejandro Sepulveda
Abstract: The disclosure relates to multiple myeloma neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the multiple myeloma neoantigens, and methods of making and using them.
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Patent Agency Ranking
公开(公告)号：US20210261609A1
公开(公告)日：2021-08-26
申请号：US17174505
申请日：2021-02-12
Applicant: Janssen Biotech, Inc.
Inventor： Vipul BHARGAVA , Vinod Krishna , David J. Pocalyko , Pegah Safabakhsh , Manuel Alejandro Sepulveda
Abstract: The disclosure relates to ovarian cancer neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the ovarian cancer neoantigens, and methods of making and using them.
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公开(公告)号：US12275766B2
公开(公告)日：2025-04-15
申请号：US17556019
申请日：2021-12-20
Applicant: Janssen Biotech, Inc.
Inventor： Vinod Krishna , Manuel Alejandro Sepulveda , Vipul Bhargava , Iqbal S. Grewal , Kurtis Bachman
IPC: C07K14/47 , A61K38/00 , A61K39/00 , C07K14/725 , C12N5/00 , C12N5/0783 , C12N9/12 , C12N9/14 , C12N9/16 , C12N15/85
Abstract: Disclosed herein are polypeptide fragments and polynucleotides based on mutant capicua transcriptional repressor (CIC), catenin beta 1 (CTNNB1), v-erb-b2 erythroblastic leukemia viral oncogene homolog B (ERBB2), kirsten rat sarcoma (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), phosphatase and tensin homolog (PTEN), splicing factor 3b subunit 1 (SF3B1), SRY-box transcription factor 17 (SOX17), tumor protein 53 (TP53), and cytomegalovirus (CMV) sequences, vectors, host cells, viruses, methods for generating CD8+ T-cells, and methods of treatment. Also disclosed herein are T-cell receptors (TCRs), polynucleotides, vectors and cells comprising the TCRs, and methods of treatment.
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公开(公告)号：US12264197B2
公开(公告)日：2025-04-01
申请号：US17437771
申请日：2020-03-11
Applicant: JANSSEN BIOTECH, INC.
Inventor： Rajkumar Ganesan , Iqbal S. Grewal , Manuel Alejandro Sepulveda
Abstract: Anti-Vβ17/anti-CD123 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies.
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公开(公告)号：US12018289B2
公开(公告)日：2024-06-25
申请号：US17097458
申请日：2020-11-13
Applicant: Janssen Biotech, Inc.
Inventor： Ricardo Attar , Jason Dehart , Selina Khan , Vinod Krishna , Jenifer Lum , Christian Maine , Barbara Sanders , Manuel Alejandro Sepulveda , Patrick Wilkinson , Roland Zahn
CPC classification number: C12N7/00 , A61K45/06 , C12N15/86 , A61K2039/505 , C12N2750/14111
Abstract: Provided are vaccines, polypeptides and polynucleotides based on mutant CALR and JAK2 sequences, vectors, host cells, viruses, and methods of making and using them. The disclosure also provides methods of inducing an immune response and methods of treating, preventing, reducing a risk of onset or delaying the onset of a clinical condition characterized by an expression of JAK2V617F or CALR exon 9 mutant, or both JAK2V617F and CALR exon 9 mutant, wherein the method comprises a plurality of administrations of any of the compositions comprising polynucleotides, polypeptides or vectors disclosed herein.
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公开(公告)号：US11945881B2
公开(公告)日：2024-04-02
申请号：US17174505
申请日：2021-02-12
Applicant: Janssen Biotech, Inc.
Inventor： Vipul Bhargava , Vinod Krishna , David J. Pocalyko , Pegah Safabakhsh , Manuel Alejandro Sepulveda
CPC classification number: C07K2/00 , A61K45/06 , C07K1/107 , C12N15/86 , A61K38/00 , C12N2710/10041 , C12N2710/24041
Abstract: The disclosure relates to ovarian cancer neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the ovarian cancer neoantigens, and methods of making and using them.
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