公开(公告)号：US12275766B2

公开(公告)日：2025-04-15

申请号：US17556019

申请日：2021-12-20

Applicant: Janssen Biotech, Inc.

Inventor： Vinod Krishna ,  Manuel Alejandro Sepulveda ,  Vipul Bhargava ,  Iqbal S. Grewal ,  Kurtis Bachman

IPC: C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/725 ,  C12N5/00 ,  C12N5/0783 ,  C12N9/12 ,  C12N9/14 ,  C12N9/16 ,  C12N15/85

Abstract: Disclosed herein are polypeptide fragments and polynucleotides based on mutant capicua transcriptional repressor (CIC), catenin beta 1 (CTNNB1), v-erb-b2 erythroblastic leukemia viral oncogene homolog B (ERBB2), kirsten rat sarcoma (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), phosphatase and tensin homolog (PTEN), splicing factor 3b subunit 1 (SF3B1), SRY-box transcription factor 17 (SOX17), tumor protein 53 (TP53), and cytomegalovirus (CMV) sequences, vectors, host cells, viruses, methods for generating CD8+ T-cells, and methods of treatment. Also disclosed herein are T-cell receptors (TCRs), polynucleotides, vectors and cells comprising the TCRs, and methods of treatment.

公开(公告)号：US20220194999A1

公开(公告)日：2022-06-23

申请号：US17556019

申请日：2021-12-20

Applicant: Janssen Biotech, Inc.

Inventor： Vinod Krishna ,  Manuel Alejandro Sepulveda ,  Vipul Bhargava ,  Iqbal S. Grewal ,  Kurtis Bachman

IPC: C07K14/47 ,  C07K14/71 ,  C07K14/725 ,  C12N15/85 ,  C12N5/0783 ,  C12N5/00 ,  C12N9/14 ,  C12N9/16 ,  C12N9/12

Abstract: Disclosed herein are polypeptide fragments and polynucleotides based on mutant capicua transcriptional repressor (CIC), catenin beta 1 (CTNNB1), v-erb-b2 erythroblastic leukemia viral oncogene homolog B (ERBB2), kirsten rat sarcoma (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), phosphatase and tensin homolog (PTEN), splicing factor 3b subunit 1 (SF3B1), SRY-box transcription factor 17 (SOX17), tumor protein 53 (TP53), and cytomegalovirus (CMV) sequences, vectors, host cells, viruses, methods for generating CD8+ T-cells, and methods of treatment. Also disclosed herein are T-cell receptors (TCRs), polynucleotides, vectors and cells comprising the TCRs, and methods of treatment.