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公开(公告)号：US12295997B2
公开(公告)日：2025-05-13
申请号：US17366946
申请日：2021-07-02
Applicant: Janssen Biotech, Inc.
Inventor： Jason Lee DeHart , Vipul Bhargava , Manuel Alejandro Sepulveda
Abstract: Disclosed herein are self-replicating RNA molecules encoding prostate neoantigens, vaccines, and methods of treating and preventing prostate cancer.
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公开(公告)号：US20240254161A1
公开(公告)日：2024-08-01
申请号：US18583364
申请日：2024-02-21
Applicant: Janssen Biotech, Inc.
Inventor： Vipul Bhargava , Vinod Krishna , David J. Pocalyko , Pegah Safabakhsh , Manuel Alejandro Sepulveda
CPC classification number: C07K2/00 , A61K45/06 , C07K1/107 , C12N15/86 , A61K38/00 , C12N2710/10041 , C12N2710/24041
Abstract: The disclosure relates to ovarian cancer neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the ovarian cancer neoantigens, and methods of making and using them.
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公开(公告)号：US20230029453A1
公开(公告)日：2023-02-02
申请号：US17366946
申请日：2021-07-02
Applicant: Janssen Biotech, Inc.
Inventor： Jason Lee DeHart , Vipul Bhargava , Manuel Alejandro Sepulveda
Abstract: Disclosed herein are self-replicating RNA molecules encoding prostate neoantigens, vaccines, and methods of treating and preventing prostate cancer.
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公开(公告)号：US12275766B2
公开(公告)日：2025-04-15
申请号：US17556019
申请日：2021-12-20
Applicant: Janssen Biotech, Inc.
Inventor： Vinod Krishna , Manuel Alejandro Sepulveda , Vipul Bhargava , Iqbal S. Grewal , Kurtis Bachman
IPC: C07K14/47 , A61K38/00 , A61K39/00 , C07K14/725 , C12N5/00 , C12N5/0783 , C12N9/12 , C12N9/14 , C12N9/16 , C12N15/85
Abstract: Disclosed herein are polypeptide fragments and polynucleotides based on mutant capicua transcriptional repressor (CIC), catenin beta 1 (CTNNB1), v-erb-b2 erythroblastic leukemia viral oncogene homolog B (ERBB2), kirsten rat sarcoma (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), phosphatase and tensin homolog (PTEN), splicing factor 3b subunit 1 (SF3B1), SRY-box transcription factor 17 (SOX17), tumor protein 53 (TP53), and cytomegalovirus (CMV) sequences, vectors, host cells, viruses, methods for generating CD8+ T-cells, and methods of treatment. Also disclosed herein are T-cell receptors (TCRs), polynucleotides, vectors and cells comprising the TCRs, and methods of treatment.
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公开(公告)号：US20200222478A1
公开(公告)日：2020-07-16
申请号：US16737950
申请日：2020-01-09
Applicant: Janssen Biotech, Inc.
Inventor： Kurtis E. Bachman , Vipul Bhargava , Darryl L. Davis , Vinod Krishna , Guido Leoni , David Pocalyko , Pegah Safabakhsh , Manuel Sepulveda , Derick Siegel , Marco Gottardis
IPC: A61K35/761 , A61K39/00 , C07K16/30
Abstract: The disclosure relates to prostate neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the prostate neoantigens, and methods of making and using them.
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Patent Agency Ranking
公开(公告)号：US11945881B2
公开(公告)日：2024-04-02
申请号：US17174505
申请日：2021-02-12
Applicant: Janssen Biotech, Inc.
Inventor： Vipul Bhargava , Vinod Krishna , David J. Pocalyko , Pegah Safabakhsh , Manuel Alejandro Sepulveda
CPC classification number: C07K2/00 , A61K45/06 , C07K1/107 , C12N15/86 , A61K38/00 , C12N2710/10041 , C12N2710/24041
Abstract: The disclosure relates to ovarian cancer neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the ovarian cancer neoantigens, and methods of making and using them.
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公开(公告)号：US11793843B2
公开(公告)日：2023-10-24
申请号：US16737950
申请日：2020-01-09
Applicant: Janssen Biotech, Inc.
Inventor： Kurtis E. Bachman , Vipul Bhargava , Darryl L. Davis , Vinod Krishna , Guido Leoni , David Pocalyko , Pegah Safabakhsh , Manuel Sepulveda , Derick Siegel , Marco Gottardis
IPC: C07K16/30 , A61K35/761 , A61K39/00 , A61K45/06
CPC classification number: A61K35/761 , A61K39/001194 , A61K39/001195 , C07K16/3069 , A61K45/06 , A61K2039/51 , A61K2039/545 , A61K2039/572
Abstract: The disclosure relates to prostate neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the prostate neoantigens, and methods of making and using them.
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公开(公告)号：US20230035403A1
公开(公告)日：2023-02-02
申请号：US17366769
申请日：2021-07-02
Applicant: Janssen Biotech, Inc.
Inventor： Denis A. Smirnov , Yashoda Rani Rajpurohit , Vipul Bhargava , Patrick Wilkinson , Kai Fu , Manuel Alejandro Sepulveda
IPC: G01N33/50 , G01N33/574 , C12Q1/686 , C12Q1/6806 , A61K35/768 , C12N7/00
Abstract: Disclosed herein are methods of diagnosing and treating a subject with prostate cancer, as well as methods of monitoring the responsiveness of a subject having prostate cancer to a therapeutic agent.
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公开(公告)号：US20230024133A1
公开(公告)日：2023-01-26
申请号：US17366545
申请日：2021-07-02
Applicant: Janssen Biotech, Inc.
Inventor： Jason Lee DeHart , Vipul Bhargava , Patrick Wilkinson , Manuel Alejandro Sepulveda
Abstract: Disclosed herein are self-replicating RNA molecules encoding prostate neoantigens, vaccines, and method of treating and preventing prostate cancer using the self-replicating RNA molecules and vaccines.
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公开(公告)号：US20220194999A1
公开(公告)日：2022-06-23
申请号：US17556019
申请日：2021-12-20
Applicant: Janssen Biotech, Inc.
Inventor： Vinod Krishna , Manuel Alejandro Sepulveda , Vipul Bhargava , Iqbal S. Grewal , Kurtis Bachman
IPC: C07K14/47 , C07K14/71 , C07K14/725 , C12N15/85 , C12N5/0783 , C12N5/00 , C12N9/14 , C12N9/16 , C12N9/12
Abstract: Disclosed herein are polypeptide fragments and polynucleotides based on mutant capicua transcriptional repressor (CIC), catenin beta 1 (CTNNB1), v-erb-b2 erythroblastic leukemia viral oncogene homolog B (ERBB2), kirsten rat sarcoma (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), phosphatase and tensin homolog (PTEN), splicing factor 3b subunit 1 (SF3B1), SRY-box transcription factor 17 (SOX17), tumor protein 53 (TP53), and cytomegalovirus (CMV) sequences, vectors, host cells, viruses, methods for generating CD8+ T-cells, and methods of treatment. Also disclosed herein are T-cell receptors (TCRs), polynucleotides, vectors and cells comprising the TCRs, and methods of treatment.
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