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公开(公告)号：US20230381108A1
公开(公告)日：2023-11-30
申请号：US18316829
申请日：2023-05-12
Applicant: AC Immune SA , Janssen Pharmaceuticals, Inc.
Inventor： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , Nicolas Piot , Saroj Raj Ghimire , Elizabeth Anne Ramsburg , Donata De Marco , Charlotte Sadaka
CPC classification number: A61K9/1271 , A61P25/28 , A61K39/0007 , A61K2039/545 , A61K2039/627 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/55516
Abstract: Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.
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公开(公告)号：US11958889B2
公开(公告)日：2024-04-16
申请号：US16757621
申请日：2018-10-24
Applicant: Janssen Pharmaceuticals, Inc. , AC Immune SA
Inventor： Elizabeth Anne Ramsburg , Donata de Marco , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , David Hickman , Nicolas Piot , Saroj Raj Ghimire
CPC classification number: C07K14/4711 , A61K9/127 , A61K9/1271 , A61K38/1709 , A61K39/0007 , A61K39/39 , A61P25/28 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/627
Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.
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Patent Agency Ranking
公开(公告)号：US11684576B2
公开(公告)日：2023-06-27
申请号：US16785011
申请日：2020-02-07
Applicant: AC Immune SA , Janssen Pharmaceuticals, Inc.
Inventor： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , Nicolas Piot , Saroj Raj Ghimire , Elizabeth Anne Ramsburg , Donata De Marco , Charlotte Sadaka
CPC classification number: A61K9/1271 , A61K39/0007 , A61P25/28 , A61K2039/545 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/627
Abstract: Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.
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公开(公告)号：US20230257433A1
公开(公告)日：2023-08-17
申请号：US18171498
申请日：2023-02-20
Applicant: Janssen Pharmaceuticals, Inc. , AC Immune SA
Inventor： Elizabeth Anne Ramsburg , Donata De Marco , Chakkumkal Anish , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , David Hickman , Nicolas Piot , Saroj Raj Ghimire
CPC classification number: C07K14/4711 , A61K39/0007 , A61K9/1271 , A61K2039/627 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/55516
Abstract: Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.
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公开(公告)号：US11591377B2
公开(公告)日：2023-02-28
申请号：US16856400
申请日：2020-04-23
Applicant: Janssen Pharmaceuticals, Inc. , AC Immune SA
Inventor： Elizabeth Anne Ramsburg , Donata De Marco , Chakkumkal Anish , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , David Hickman , Nicolas Piot , Saroj Raj Ghimire
Abstract: Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.
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公开(公告)号：US11124552B2
公开(公告)日：2021-09-21
申请号：US16169215
申请日：2018-10-24
Applicant: Janssen Pharmaceuticals, Inc. , AC Immune SA
Inventor： Elizabeth Anne Ramsburg , Donata De Marco , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , Nicolas Piot , Saroj Raj Ghimire
Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.
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公开(公告)号：US20190119341A1
公开(公告)日：2019-04-25
申请号：US16169215
申请日：2018-10-24
Applicant: Janssen Pharmaceuticals, Inc. , AC Immune S.A.
Inventor： Elizabeth Anne Ramsburg , Donata De Marco , Anish Chakkumkal , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , David Hickman , Nicolas Piot , Saroj Raj Ghimire
Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.
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