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公开(公告)号：US06225320B1
公开(公告)日：2001-05-01
申请号：US09424108
申请日：1999-11-18
申请人： Janusz Jozef Kulagowski , Piotr Antoni Raubo , Christopher John Swain , Christopher George Thomson
发明人： Janusz Jozef Kulagowski , Piotr Antoni Raubo , Christopher John Swain , Christopher George Thomson
IPC分类号： C07D22120
CPC分类号： C07D491/10
摘要： Substituted spiro-azacyclic derivatives of structural formula I are tachykinin receptor antagonists of use, for example, in the treatment of pain, inflammation, migraine, emesis and posttherpetic neuralgia Wherein A is a pyridyl, X is —CH2—, Y is —CH2— or —CH═ and q is 2.
摘要翻译： 结构式I的取代的螺 - 氮杂环衍生物是速激肽受体拮抗剂，例如用于治疗疼痛，炎症，偏头痛，呕吐和疱疹后神经痛。其中A是吡啶基，X是-CH 2 - ，Y是-CH 2 - 或 - -CH =和q为2。
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公开(公告)号：US06555552B2
公开(公告)日：2003-04-29
申请号：US10113965
申请日：2002-04-01
IPC分类号： A61K3146
CPC分类号： C07D451/02 , A61M15/0048 , C07C45/00 , C07C45/29 , C07C45/40 , C07D451/04 , C07D451/06 , G01F11/003 , C07C47/575 , C07C49/84
摘要： The present invention relates compounds of the formula (I): wherein X represents hydrogen or a C1-4alkyl group optionally substituted by a hydroxy group; Y represents hydrogen, C1-6alkyl or C3-7cycloalkyl; Z is —CR9R10CH2— or —CH2CR9R10—; R represents hydrogen, fluorine, hydroxy, C1-6alkyl or C1-6alkoxy; and R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are of particular use in the treatment of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
摘要翻译： 本发明涉及式（I）的化合物：其中X表示氢或任选被羟基取代的C 1-4烷基; Y表示氢，C 1-6烷基或C 3-7环烷基; Z表示-CR 9 R 10 CH 2 - 或-CH 2 CR 9 R 10 - ; R代表氢，氟，羟基，C1-6烷基或C1-6烷氧基; R1，R2，R3，R4，R5和R6如本文所定义。化合物特别用于治疗抑郁，焦虑，疼痛，炎症 ，偏头痛，呕吐或带状疱疹后神经痛。
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公开(公告)号：US08163956B2
公开(公告)日：2012-04-24
申请号：US11922074
申请日：2006-06-13
申请人： Wesley Peter Blackaby , Ian Thomas Huscroft , Linda Elizabeth Keown , Richard Thomas Lewis , Piotr Antoni Raubo , Leslie Joseph Street , Christopher George Thomson , Joanne Thomson
发明人： Wesley Peter Blackaby , Ian Thomas Huscroft , Linda Elizabeth Keown , Richard Thomas Lewis , Piotr Antoni Raubo , Leslie Joseph Street , Christopher George Thomson , Joanne Thomson
IPC分类号： C07C303/00 , C07C233/00 , C07C237/00 , C07C323/00 , A61K31/16 , A61K31/165
CPC分类号： C07D249/04 , C07C317/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/08 , C07D207/09 , C07D211/26 , C07D211/28 , C07D211/60 , C07D213/40 , C07D249/12 , C07D295/067 , C07D309/04 , C07D401/12
摘要： A compound of the formula (I): wherein R1, R2, R3, R4, Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are their use in medicine, for example in the treatment of schizophrenia.
摘要翻译： 公开了式（I）化合物：其中R 1，R 2，R 3，R 4，Ar，A，n和m如本文所定义，被公开为GlyT1抑制剂; 还公开了含有式（I）化合物的药物组合物，它们在医学中的用途，例如在精神分裂症的治疗中。
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公开(公告)号：US20090286765A1
公开(公告)日：2009-11-19
申请号：US11922074
申请日：2006-06-13
申请人： Wesley Peter Blackaby , Ian Thomas Huscroft , Linda Elizabeth Keown , Richard Thomas Lewis , Piotr Antoni Raubo , Leslie Joseph Street , Christopher George Thomson , Joanne Thomson
发明人： Wesley Peter Blackaby , Ian Thomas Huscroft , Linda Elizabeth Keown , Richard Thomas Lewis , Piotr Antoni Raubo , Leslie Joseph Street , Christopher George Thomson , Joanne Thomson
IPC分类号： A61K31/397 , C07C233/00 , A61K31/165 , C07D211/32 , A61K31/445 , C07D413/14 , A61K31/5377
CPC分类号： C07D249/04 , C07C317/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/08 , C07D207/09 , C07D211/26 , C07D211/28 , C07D211/60 , C07D213/40 , C07D249/12 , C07D295/067 , C07D309/04 , C07D401/12
摘要： A compound of the formula (I): wherein R1, R2, R3, R4, Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are their use in medicine, for example in the treatment of schizophrenia.
摘要翻译： 公开了式（I）化合物：其中R 1，R 2，R 3，R 4，Ar，A，n和m如本文所定义，被公开为GlyT1抑制剂; 还公开了含有式（I）化合物的药物组合物，它们在医学中的用途，例如在精神分裂症的治疗中。
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