公开(公告)号：US20210001013A1

公开(公告)日：2021-01-07

申请号：US17024262

申请日：2020-09-17

Applicant: Japan Medical Device Technology Co., LTD. ,  FUJI LIGHT METAL CO., LTD.

Inventor： Makoto SASAKI ,  Yuki KOGA ,  Yuki OKAZAWA ,  Hironori UEDA ,  Masashi INOUE ,  Shuzo YAMASHITA

IPC: A61L31/02 ,  A61L31/08 ,  A61L31/14 ,  A61L31/16 ,  C08L65/04 ,  A61L31/10

Abstract: Provided is a biodegradable stent comprising a magnesium alloy free of a rare earth element and aluminum. The stent comprises: a core structure comprising a magnesium alloy containing 90 wt % or more of magnesium as a main component, and zinc, zirconium, and manganese as accessary components, the magnesium alloy being free of a rare earth element and aluminum; a first corrosion resistant layer formed on the core structure and containing magnesium fluoride as a main component; and a second corrosion resistant layer formed on the first corrosion resistant layer and comprising a parylene. A method for producing such a bioabsorbable stent is also provided.

公开(公告)号：US20210353836A1

公开(公告)日：2021-11-18

申请号：US17386728

申请日：2021-07-28

Applicant: Japan Medical Device Technology Co., Ltd.

Inventor： Shuzo YAMASHITA ,  Makoto SASAKI ,  Akira WADA

IPC: A61L31/14 ,  A61L31/08 ,  A61L31/02 ,  A61L31/10 ,  A61L31/16

Abstract: Provided are a magnesium alloy stent with improved corrosion resistance, and a method for producing same. The bioabsorbable stent including a core structure of a magnesium alloy, the stent is composed of: a first anticorrosive layer containing magnesium fluoride as a main component formed on the core structure, and a second anticorrosive layer coated with a diamond-like carbon on the first anticorrosive layer.

公开(公告)号：US20180264180A1

公开(公告)日：2018-09-20

申请号：US15988482

申请日：2018-05-24

Applicant: Japan Medical Device Technology Co., Ltd. ,  National University Corporation Kumamoto University

Inventor： Makoto SASAKI ,  Takuro NIIDOME ,  Zhen Yu JIN ,  Shuzo YAMASHITA

IPC: A61L31/14 ,  A61F2/915 ,  A61L31/10 ,  A61L31/02 ,  A61L31/16

CPC classification number: A61L31/148 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/003 ,  A61F2250/0046 ,  A61L31/022 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/608 ,  A61L2420/08 ,  C08L67/04

Abstract: Provided is a biodegradable polymer coating stent effective in delaying the damage of physical properties (particularly radial force) of a core structure. The stent includes a core structure of a bioabsorbable material (e.g., Mg), a first coating layer of a first polymer with biodegradability, and a second coating layer of a second polymer with biodegradability, wherein the first coating layer covers the whole surface of the core structure; the second coating layer covers a part or the whole surface of the first coating layer; the first polymer has a glass transition point of lower than 37° C.; and the second polymer has a glass transition point of 47° C. or higher.

公开(公告)号：US20220033974A1

公开(公告)日：2022-02-03

申请号：US17486372

申请日：2021-09-27

Applicant: Japan Medical Device Technology Co., Ltd.

Inventor： Shuzo YAMASHITA ,  Makoto SASAKI ,  Akira WADA

IPC: C23C28/04 ,  C23C16/26 ,  C22C23/04 ,  A61L31/02

Abstract: To provide a magnesium alloy with improved corrosion resistance by surface modification, and a production method thereof. (1) The surface-modified magnesium alloy comprising: a magnesium alloy having an arbitrary shape; a magnesium fluoride layer formed by fluorination of the surface of the magnesium alloy; and a diamond-like carbon layer formed on the magnesium fluoride layer. (2) The method comprising: subjecting a surface of a magnesium alloy having an arbitrary shape to fluorination treatment to form a magnesium fluoride layer on the surface of the magnesium alloy, and then subjecting the magnesium alloy with the magnesium fluoride layer to be placed in a high-frequency plasma CVD device such that a source gas containing carbon is introduced to form a diamond-like carbon layer on the magnesium fluoride layer.

公开(公告)号：US20220008625A1

公开(公告)日：2022-01-13

申请号：US17486150

申请日：2021-09-27

Applicant: Japan Medical Device Technology Co., Ltd.

Inventor： Shuzo YAMASHITA ,  Makoto SASAKI ,  Akira WADA

IPC: A61L27/58 ,  A61L27/04 ,  A61L27/30 ,  C22C23/04 ,  C23C28/00

Abstract: A bioabsorbable implant for non-luminal region comprising: a core structure including a magnesium alloy having a predetermined shape; a first corrosion-resistant layer containing a magnesium fluoride layer as a main component formed on the core structure via fluorination of a surface of the magnesium alloy; and a second corrosion-resistant layer containing a parylene formed on the magnesium fluoride layer.