公开(公告)号：US11685975B2

公开(公告)日：2023-06-27

申请号：US17138492

申请日：2020-12-30

Applicant: Japan Medical Device Technology Co., LTD.

Inventor： Hironori Ueda ,  Masashi Inoue ,  Makoto Sasaki

IPC: C22C23/04 ,  A61L31/02 ,  C22C1/02 ,  C22F1/06 ,  A61L27/04 ,  A61L31/14 ,  A61L27/50

CPC classification number: C22C23/04 ,  A61L27/047 ,  A61L27/50 ,  A61L31/022 ,  A61L31/14 ,  C22C1/02 ,  C22C2202/00 ,  C22F1/06

Abstract: A magnesium alloy containing, in % by mass, 0.95 to 2.00% of Zn, 0.05% or more and less than 0.30% of Zr, 0.05 to 0.20% of Mn, and the balance consisting of Mg and unavoidable impurities, wherein the magnesium alloy has a particle size distribution with an average crystal particle size from 1.0 to 3.0 μm and a standard deviation of 0.7 or smaller.

公开(公告)号：US11207448B2

公开(公告)日：2021-12-28

申请号：US15988482

申请日：2018-05-24

Applicant: Japan Medical Device Technology Co., Ltd. ,  National University Corporation Kumamoto University

Inventor： Makoto Sasaki ,  Takuro Niidome ,  Zhen Yu Jin ,  Shuzo Yamashita

IPC: A61F2/915 ,  A61L31/14 ,  A61F2/90 ,  A61L31/02 ,  A61L31/10 ,  A61L31/16

Abstract: Provided is a biodegradable polymer coating stent effective in delaying the damage of physical properties (particularly radial force) of a core structure. The stent includes a core structure of a bioabsorbable material (e.g., Mg), a first coating layer of a first polymer with biodegradability, and a second coating layer of a second polymer with biodegradability, wherein the first coating layer covers the whole surface of the core structure; the second coating layer covers a part or the whole surface of the first coating layer; the first polymer has a glass transition point of lower than 37° C.; and the second polymer has a glass transition point of 47° C. or higher.

公开(公告)号：US20210001013A1

公开(公告)日：2021-01-07

申请号：US17024262

申请日：2020-09-17

Applicant: Japan Medical Device Technology Co., LTD. ,  FUJI LIGHT METAL CO., LTD.

Inventor： Makoto SASAKI ,  Yuki KOGA ,  Yuki OKAZAWA ,  Hironori UEDA ,  Masashi INOUE ,  Shuzo YAMASHITA

IPC: A61L31/02 ,  A61L31/08 ,  A61L31/14 ,  A61L31/16 ,  C08L65/04 ,  A61L31/10

Abstract: Provided is a biodegradable stent comprising a magnesium alloy free of a rare earth element and aluminum. The stent comprises: a core structure comprising a magnesium alloy containing 90 wt % or more of magnesium as a main component, and zinc, zirconium, and manganese as accessary components, the magnesium alloy being free of a rare earth element and aluminum; a first corrosion resistant layer formed on the core structure and containing magnesium fluoride as a main component; and a second corrosion resistant layer formed on the first corrosion resistant layer and comprising a parylene. A method for producing such a bioabsorbable stent is also provided.

公开(公告)号：US12109333B2

公开(公告)日：2024-10-08

申请号：US17024262

申请日：2020-09-17

Applicant: Japan Medical Device Technology Co., LTD. ,  FUJI LIGHT METAL CO., LTD.

Inventor： Makoto Sasaki ,  Yuki Koga ,  Yuki Okazawa ,  Hironori Ueda ,  Masashi Inoue ,  Shuzo Yamashita

IPC: A61L31/02 ,  A61F2/82 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  C08L65/04

CPC classification number: A61L31/022 ,  A61F2/82 ,  A61L31/088 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  C08L65/04 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2250/0068 ,  A61L2300/416 ,  A61L2420/02 ,  A61L2420/08 ,  C08L2201/06 ,  C08L2203/02

Abstract: Provided is a biodegradable stent comprising a magnesium alloy free of a rare earth element and aluminum. The stent comprises: a core structure comprising a magnesium alloy containing 90 wt % or more of magnesium as a main component, and zinc, zirconium, and manganese as accessary components, the magnesium alloy being free of a rare earth element and aluminum; a first corrosion resistant layer formed on the core structure and containing magnesium fluoride as a main component; and a second corrosion resistant layer formed on the first corrosion resistant layer and comprising a parylene. A method for producing such a bioabsorbable stent is also provided.

公开(公告)号：US11135075B2

公开(公告)日：2021-10-05

申请号：US16525123

申请日：2019-07-29

Applicant: KAKE EDUCATIONAL INSTITUTION OKAYAMA UNIVERSITY OF SCIENCE ,  Japan Medical Device Technology Co., LTD.

Inventor： Ichiro Shimizu ,  Akira Wada ,  Makoto Sasaki

IPC: A61F2/915

Abstract: To provide a bioabsorbable stent including: a first tubular unit containing a plurality of cells coupled to each other, each of the cells formed from substantially linear parts and a substantially circular arc part and having a substantially U shape which opens to one end in the axial direction of the stent; and a second tubular unit having the same shape as that of the first tubular unit, the second tubular unit containing a plurality of cells each of which has a substantially U shape which opens to a direction opposite to the opening direction of the opposing first cell. The first tubular unit and the second tubular unit are alternately arranged in sequence to surround a central axis of the stent. Coupling members couple substantially linear parts in some of the opposing cells in the respective neighboring tubular units.

公开(公告)号：US09480550B2

公开(公告)日：2016-11-01

申请号：US14460351

申请日：2014-08-14

Applicant: CLINO LTD. ,  PIOLAX MEDICAL DEVICES, INC. ,  JAPAN Medical Device Technology Co., Ltd.

Inventor： Kiyoshi Yamauchi

IPC: A61F2/04 ,  B23K26/14 ,  B23K26/38 ,  A61F2/91 ,  A61F2/82

CPC classification number: A61F2/04 ,  A61F2/82 ,  A61F2/91 ,  A61F2210/0014 ,  A61F2240/001 ,  A61F2250/0018 ,  B23K26/146 ,  B23K26/38

Abstract: A highly elastic stent is made of an alloy that exhibits superelasticity at body temperature. At least a part of the highly elastic stent has such a property that load increases with displacement without exhibiting a distinct yield on a load-displacement curve obtained by a compression test and a bending test.

Abstract translation: 高弹性支架由在体温下显示超弹性的合金制成。 高弹性支架的至少一部分具有负载随位移而增加的性质，而在通过压缩试验和弯曲试验得到的载荷 - 位移曲线上没有明显的屈服。

公开(公告)号：US11248282B2

公开(公告)日：2022-02-15

申请号：US16506298

申请日：2019-07-09

Applicant: FUJI LIGHT METAL CO., LTD. ,  Japan Medical Device Technology Co., LTD.

Inventor： Hironori Ueda ,  Masashi Inoue ,  Makoto Sasaki

IPC: C22C23/04 ,  A61L31/02

Abstract: Magnesium alloy containing, in % by mass, 1.0 to 2.0% of Zn, 0.05 to 0.80% by mass of Zr, 0.05 to 0.40% by mass of Mn, and the balance consisting of Mg and unavoidable impurities. The magnesium alloy may further contain, in % by mass, 0.005% or more and less than 0.20% of Ca.

公开(公告)号：US20210353836A1

公开(公告)日：2021-11-18

申请号：US17386728

申请日：2021-07-28

Applicant: Japan Medical Device Technology Co., Ltd.

Inventor： Shuzo YAMASHITA ,  Makoto SASAKI ,  Akira WADA

IPC: A61L31/14 ,  A61L31/08 ,  A61L31/02 ,  A61L31/10 ,  A61L31/16

Abstract: Provided are a magnesium alloy stent with improved corrosion resistance, and a method for producing same. The bioabsorbable stent including a core structure of a magnesium alloy, the stent is composed of: a first anticorrosive layer containing magnesium fluoride as a main component formed on the core structure, and a second anticorrosive layer coated with a diamond-like carbon on the first anticorrosive layer.

公开(公告)号：US11160674B2

公开(公告)日：2021-11-02

申请号：US16523645

申请日：2019-07-26

Applicant: Japan Medical Device Technology Co., LTD. ,  FUJI LIGHT METAL CO., LTD.

Inventor： Makoto Sasaki ,  Yuki Koga ,  Yuki Okazawa ,  Hironori Ueda ,  Masashi Inoue

IPC: A61L31/02 ,  A61L31/14 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61F2/90 ,  A61F2/958

Abstract: To provide a stent excellent in deformability, capable of maintaining a radial force for a longer period of time, and having bioabsorbability and a method of producing the same. The bioabsorbable stent has a core structure including a magnesium alloy and a corrosion resistant layer on the core structure, wherein the core structure is formed from a magnesium alloy containing 90 mass % or more of Mg as a main component, Zn, Zr, and Mn as accessory components, and 30 ppm or less of unavoidable impurities selected from the group consisting of Fe, Ni, Co, and Cu, and the alloy excluding aluminum and at least one sort of rare earths selected from the group consisting of Sc, Y, Dy, Sm, Ce, Gd, and La; and the corrosion resistant layer containing magnesium fluoride as a main component with a hydrophilic smooth surface is formed on the core structure with a smooth surface.

公开(公告)号：US20190350732A1

公开(公告)日：2019-11-21

申请号：US16525123

申请日：2019-07-29

Applicant: KAKE EDUCATIONAL INSTITUTION OKAYAMA UNIVERSITY OF SCIENCE ,  Japan Medical Device Technology Co., LTD.

Inventor： Ichiro SHIMIZU ,  Akira WADA ,  Makoto SASAKI

IPC: A61F2/915

Abstract: To provide a bioabsorbable stent including: a first tubular unit containing a plurality of cells coupled to each other, each of the cells formed from substantially linear parts and a substantially circular arc part and having a substantially U shape which opens to one end in the axial direction of the stent; and a second tubular unit having the same shape as that of the first tubular unit, the second tubular unit containing a plurality of cells each of which has a substantially U shape which opens to a direction opposite to the opening direction of the opposing first cell. The first tubular unit and the second tubular unit are alternately arranged in sequence to surround a central axis of the stent. Coupling members couple substantially linear parts in some of the opposing cells in the respective neighboring tubular units.