公开(公告)号：US20030096947A1

公开(公告)日：2003-05-22

申请号：US10339513

申请日：2003-01-09

Applicant: Japan Science and Technology Corporation, Japan

Inventor： Hitoshi Endou ,  Takashi Sekine ,  Seok Ho Cha

IPC: C07K014/47 ,  C12Q001/68 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07K14/47 ,  C07K14/705 ,  C12Q1/6876 ,  C12Q2600/158

Abstract: A novel organic anion transporter gene participating in organic anion transport in the placenta; and an organic anion transporter which is a polypeptide encoded by the gene. A placental organic anion transporter OAT4, more particularly, a placental organic anion transporter OAT4 having the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequence derived therefrom by deletion, substitution or addition of a part of the amino acids thereof. A nucleic acid (preferably DNA) having a base sequence encoding the placental organic anion transporter OAT4 or a base sequence hybridizable therewith under stringent conditions.

Abstract translation: 参与胎盘中有机阴离子转运的新型有机阴离子转运蛋白基因; 和由该基因编码的多肽的有机阴离子转运蛋白。 胎盘有机阴离子转运蛋白OAT4，更特别是具有由SEQ ID NO：2表示的氨基酸序列的胎盘有机阴离子转运蛋白OAT4或其部分氨基酸的缺失，取代或添加导致的氨基酸序列。 具有编码胎盘有机阴离子转运蛋白OAT4的碱基序列或在严格条件下可与其杂交的碱基序列的核酸（优选DNA）。

公开(公告)号：US20030148444A1

公开(公告)日：2003-08-07

申请号：US10214867

申请日：2002-08-07

Applicant: Japan Science and Technology Corporation, Japan

Inventor： Hitoshi Endou ,  Yoshikatsu Kanai

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07H021/04

CPC classification number: C07K14/47

Abstract: Novel sodium-independent small neutral amino acid transporters which transport L- and D-amino acids. A protein comprising the amino acid sequence represented by SEQ ID NO:1 or 4 or an amino acid derived therefrom by deletion, substitution or addition of one or more amino acids and being capable of sodium-independently transporting L- and D-small neutral amino acids and analogs thereof; a gene encoding the above protein; a method of screening substances inhibiting or promoting the function of the above protein; an antibody against the above protein; and a method of regulating cell function by using the above antibody, function inhibitors, function promoters, etc.

Abstract translation: 新型不依赖钠的小中性氨基酸转运蛋白，其转运L-和D-氨基酸。 包含SEQ ID NO：1或SEQ ID NO：1所示的氨基酸序列的蛋白质或由其衍生的氨基酸，通过缺失，取代或添加一个或多个氨基酸并且能够独立地将L-和D-小中性氨基酸 酸及其类似物; 编码上述蛋白质的基因; 筛选抑制或促进上述蛋白质功能的物质的方法; 针对上述蛋白质的抗体; 以及通过使用上述抗体，功能抑制剂，功能促进剂等调节细胞功能的方法