公开(公告)号：US11643417B2

公开(公告)日：2023-05-09

申请号：US17493528

申请日：2021-10-04

申请人： Japan Tobacco Inc.

发明人： Masafumi Inoue ,  Yosuke Ogoshi ,  Takayuki Furukawa ,  Takuya Machida ,  Ikuo Mitani ,  Kazuhito Harada ,  Yuichi Nakagawa ,  Nobutaka Yamaoka

IPC分类号： C07D491/048 ,  C07D491/107 ,  C07D519/00 ,  A61K31/551 ,  A61P9/12 ,  A61P11/00 ,  A61P17/06 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07D491/048

摘要： The present invention provides a compound having a Pim-1 inhibitory activity.
The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like.




wherein each symbol is as defined in the description.

公开(公告)号：US10752596B2

公开(公告)日：2020-08-25

申请号：US16150989

申请日：2018-10-03

申请人： JAPAN TOBACCO INC.

发明人： Hironobu Nagamori ,  Tatsuya Nishimaru ,  Masaki Takagi ,  Ikuo Mitani ,  Yuichi Nakagawa

IPC分类号： C07D241/12 ,  C07D213/46 ,  A61P19/06 ,  C07D405/10 ,  A61P43/00 ,  A61K31/4965 ,  C07D217/16 ,  A61K31/497 ,  C07D213/55 ,  A61K31/4433 ,  A61K31/4418 ,  C07D405/04 ,  A61K31/472

摘要： The invention provides a compound having a GLUT9 inhibitory activity. The compound is of Formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240116943A1

公开(公告)日：2024-04-11

申请号：US18124389

申请日：2023-03-21

申请人： Japan Tobacco Inc.

发明人： Masafumi Inoue ,  Yosuke Ogoshi ,  Takayuki Furukawa ,  Takuya Machida ,  Ikuo Mitani ,  Kazuhito Harada ,  Yuichi Nakagawa ,  Nobutaka Yamaoka

IPC分类号： C07D491/048

CPC分类号： C07D491/048

摘要： The present invention provides a compound having a Pim-1 inhibitory activity.
The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like.




wherein each symbol is as defined in the description.

公开(公告)号：US20150266834A1

公开(公告)日：2015-09-24

申请号：US14626243

申请日：2015-02-19

申请人： Japan Tobacco Inc.

发明人： Hironobu Nagamori ,  Ikuo Mitani ,  Masaki Yamashita ,  Takahiro Hotta ,  Yuichi Nakagawa ,  Masatoshi Ueda

IPC分类号： C07D251/22 ,  A61K45/06 ,  A61K31/53

摘要： Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.

摘要翻译： 提供具有mPGES-1抑制活性的化合物，其可用于预防或治疗疼痛，风湿病，骨关节炎，发烧，阿尔茨海默病，多发性硬化，动脉硬化，青光眼，眼高血压，缺血性视网膜疾病，系统性硬皮病和包括结肠直肠癌 癌症。 由式[I]表示的化合物或其药学上可接受的盐：其中每个符号如规范中所定义。

公开(公告)号：US20230011968A1

公开(公告)日：2023-01-12

申请号：US17575931

申请日：2022-01-14

申请人： Japan Tobacco Inc.

发明人： Hironobu Nagamori ,  Ikuo Mitani ,  Masaki Yamashita ,  Takahiro Hotta ,  Yuichi Nakagawa ,  Masatoshi Ueda

IPC分类号： C07D251/22 ,  A61P27/06 ,  A61K31/53 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D405/12 ,  C07D471/10 ,  A61K45/06

摘要： Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.
A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.

公开(公告)号：US20220162220A1

公开(公告)日：2022-05-26

申请号：US17493528

申请日：2021-10-04

申请人： Japan Tobacco Inc.

发明人： Masafumi Inoue ,  Yosuke Ogoshi ,  Takayuki Furukawa ,  Takuya Machida ,  Ikuo Mitani ,  Kazuhito Harada ,  Yuichi Nakagawa ,  Nobutaka YAMAOKA

IPC分类号： C07D491/048

摘要： The present invention provides a compound having a Pim-1 inhibitory activity.
The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like. wherein each symbol is as defined in the description.

公开(公告)号：US20200087266A1

公开(公告)日：2020-03-19

申请号：US16396503

申请日：2019-04-26

申请人： Japan Tobacco Inc.

发明人： Hironobu Nagamori ,  Ikuo Mitani ,  Masaki Yamashita ,  Takahiro Hotta ,  Yuichi Nakagawa ,  Masatoshi Ueda

IPC分类号： C07D251/22 ,  A61P27/06 ,  A61K31/53 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D405/12 ,  C07D471/10 ,  A61K45/06

摘要： Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.