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公开(公告)号:US20050154014A1
公开(公告)日:2005-07-14
申请号:US10973870
申请日:2004-10-26
申请人: Jason Bloxham , Andrew Crew , Ayako Honda , An-Hu Li , Bijoy Panicker , Lawrence Tardibono , Graham Wynne
发明人: Jason Bloxham , Andrew Crew , Ayako Honda , An-Hu Li , Bijoy Panicker , Lawrence Tardibono , Graham Wynne
IPC分类号: A61K31/381 , A61K31/437 , A61K31/4436 , A61K31/4709 , A61K31/4745 , A61K45/06 , C07D409/12 , C07D409/14 , C07D471/04 , C07D49/02
CPC分类号: A61K31/381 , A61K31/437 , A61K31/4436 , A61K31/4709 , A61K31/4745 , A61K45/06 , C07D409/12 , C07D409/14 , C07D471/04 , A61K2300/00
摘要: Amidoaryl/amidoheteroaryl substituted thiophenes, further substituted with a heteroarylmethylamino group, are useful in the treatment of cancer.
摘要翻译: 进一步被杂芳基甲基氨基取代的酰胺芳基/酰胺基芳基取代的噻吩可用于治疗癌症。
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公开(公告)号:US20060235031A1
公开(公告)日:2006-10-19
申请号:US11095162
申请日:2005-03-31
申请人: Lee Arnold , Heather Coate , Andrew Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Mark Mulvihill , Anthony Nigro , Bijoy Panicker , Arno Steinig , Qingua Weng , Douglas Werner , Michael Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee Arnold , Heather Coate , Andrew Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Mark Mulvihill , Anthony Nigro , Bijoy Panicker , Arno Steinig , Qingua Weng , Douglas Werner , Michael Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: A61K31/52
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 下式的化合物及其药学上可接受的盐,其中X 1,X 2,X 3,X 4, X 5,X 6,X 7,R 1和Q 1 在本文中定义,抑制IGF-1R酶,并且可用于治疗和/或预防过度增殖性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢的疾病和状况 神经系统。
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公开(公告)号:US20060189629A1
公开(公告)日:2006-08-24
申请号:US10921414
申请日:2004-08-16
申请人: Joshua Bolger , Arlindo Castelhano , Andrew Crew , Han-Qing Dong , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Li Qiu , Colin Sambrook Smith , Yingchaun Sun , Graham Wynne , Tao Zhang
发明人: Joshua Bolger , Arlindo Castelhano , Andrew Crew , Han-Qing Dong , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Li Qiu , Colin Sambrook Smith , Yingchaun Sun , Graham Wynne , Tao Zhang
IPC分类号: A61K31/496 , A61K31/454 , A61K31/4184 , C07D403/02
CPC分类号: C07D235/06 , C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
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公开(公告)号:US07618965B2
公开(公告)日:2009-11-17
申请号:US11227697
申请日:2005-09-15
申请人: Andrew Crew , An-Hu Li , Bijoy Panicker
发明人: Andrew Crew , An-Hu Li , Bijoy Panicker
IPC分类号: A61K31/535 , A61K31/47 , C07D413/00 , C07D215/00 , C07D215/02
CPC分类号: C07D409/12 , C07D409/14
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R1, R2, and R5 are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.
摘要翻译: 式(I)表示的化合物或其药学上可接受的盐或N-氧化物,其中A,Q,Y,R 1,R 2和R 5在本文中定义,可用于治疗肿瘤和癌症,例如肥大细胞增多症/桅杆 细胞白血病,胃肠道间质瘤(GIST),生殖细胞肿瘤,小细胞肺癌(SCLC),鼻窦自然杀伤/ T细胞淋巴瘤,睾丸癌(精原细胞瘤),甲状腺癌,恶性黑素瘤,卵巢癌,腺样囊性癌, 急性骨髓性白血病(AML),乳腺癌,儿科T细胞急性淋巴细胞白血病,成神经细胞瘤,肥大细胞白血病,血管肉瘤,间变性大细胞淋巴瘤,子宫内膜癌和前列腺癌。
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公开(公告)号:US20060069121A1
公开(公告)日:2006-03-30
申请号:US11227697
申请日:2005-09-15
申请人: Andrew Crew , An-Hu Li , Bijoy Panicker
发明人: Andrew Crew , An-Hu Li , Bijoy Panicker
IPC分类号: A61K31/4709 , C07D409/14
CPC分类号: C07D409/12 , C07D409/14
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R1, R2, and R5 are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.
摘要翻译: 由式(I)表示的化合物:
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公开(公告)号:US20060111349A1
公开(公告)日:2006-05-25
申请号:US11227699
申请日:2005-09-15
申请人: Arlindo Castelhano , Andrew Crew , Hanqing Dong , An-Hu Li , Li Qiu , Alun Smith , Lawrence Tardibono , Tao Zhang
发明人: Arlindo Castelhano , Andrew Crew , Hanqing Dong , An-Hu Li , Li Qiu , Alun Smith , Lawrence Tardibono , Tao Zhang
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/14 , C07D409/14
CPC分类号: C07D409/14 , C07D409/12
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R5, m and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐或N-氧化物,其中A,Q,Y,R 5,m和J如本文所定义,可用于治疗肿瘤 和肥大细胞增多症/肥大细胞白血病,胃肠道间质肿瘤(GIST),生殖细胞肿瘤,小细胞肺癌(SCLC),鼻窦自然杀伤/ T细胞淋巴瘤,睾丸癌(精原细胞瘤),甲状腺癌,恶性黑素瘤, 卵巢癌,腺样囊性癌,急性骨髓性白血病(AML),乳腺癌,儿科T细胞急性淋巴细胞白血病,成神经细胞瘤,肥大细胞白血病,血管肉瘤,间变性大细胞淋巴瘤,子宫内膜癌和前列腺癌。
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公开(公告)号:US07829717B2
公开(公告)日:2010-11-09
申请号:US11227699
申请日:2005-09-15
申请人: Arlindo L. Castelhano , Andrew Crew , Hanqing Dong , An-Hu Li , Li Qiu , Alun Smith , Lawrence Tardibono , Tao Zhang
发明人: Arlindo L. Castelhano , Andrew Crew , Hanqing Dong , An-Hu Li , Li Qiu , Alun Smith , Lawrence Tardibono , Tao Zhang
IPC分类号: C07D215/12 , A61K31/47
CPC分类号: C07D409/14 , C07D409/12
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R5, m and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.
摘要翻译: 式(I)表示的化合物或其药学上可接受的盐或N-氧化物,其中A,Q,Y,R 5,m和J如本文所定义,可用于治疗肿瘤和癌症如肥大细胞增多症/肥大细胞 白血病,胃肠道间质瘤(GIST),生殖细胞肿瘤,小细胞肺癌(SCLC),鼻窦自然杀伤/ T细胞淋巴瘤,睾丸癌(精原细胞瘤),甲状腺癌,恶性黑素瘤,卵巢癌,腺样囊性癌,急性 骨髓性白血病(AML),乳腺癌,儿科T细胞急性淋巴细胞白血病,成神经细胞瘤,肥大细胞白血病,血管肉瘤,间变性大细胞淋巴瘤,子宫内膜癌和前列腺癌。
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公开(公告)号:US20070112005A1
公开(公告)日:2007-05-17
申请号:US11599663
申请日:2006-11-15
申请人: Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
发明人: Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
IPC分类号: A61K31/498 , A61K31/53 , C07D487/12
CPC分类号: C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐是mTOR的抑制剂,可用于治疗癌症。
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公开(公告)号:US20060223799A1
公开(公告)日:2006-10-05
申请号:US11397031
申请日:2006-03-30
申请人: Andrew Crew , Bijoy Panicker , Han-Qing Dong
发明人: Andrew Crew , Bijoy Panicker , Han-Qing Dong
IPC分类号: A61K31/5377 , A61K31/4439 , A61K31/4188 , C07D487/02
CPC分类号: C07D487/04
摘要: or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors and cancers.
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公开(公告)号:US20060074082A1
公开(公告)日:2006-04-06
申请号:US11227346
申请日:2005-09-15
申请人: Arlindo Castelhano , Andrew Crew , Hanqing Dong , An-Hu Li , Li Qiu , Alun Smith
发明人: Arlindo Castelhano , Andrew Crew , Hanqing Dong , An-Hu Li , Li Qiu , Alun Smith
IPC分类号: A61K31/5377 , A61K31/4709 , C07D413/14 , C07D409/14
CPC分类号: C07D409/12 , C07D409/14
摘要: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R5 and J are defined herein, are useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐或N-氧化物,其中A,Q,Y,R 5和J如本文所定义,可用于治疗癌症。
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