公开(公告)号：US20080107750A1

公开(公告)日：2008-05-08

申请号：US11851923

申请日：2007-09-07

申请人： Jason Hodde ,  David Ernst ,  Lal Ninan ,  Sherry Voytik-Harbin ,  Nathan Hammond

发明人： Jason Hodde ,  David Ernst ,  Lal Ninan ,  Sherry Voytik-Harbin ,  Nathan Hammond

IPC分类号： A61K35/12 ,  A61P43/00 ,  A61L2/00 ,  A61L2/16

CPC分类号： A61K35/37 ,  A61K35/38 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3687 ,  A61K2300/00

摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.

摘要翻译： 描述了含有受控水平的生长因子如成纤维细胞生长因子-2（FGF-2）的包装的无菌医用移植物产品。 还描述了制造医疗移植产品的方法，其中控制和监测包括灭菌在内的处理以提供具有调节的已知水平的细胞外基质因子例如生长因子的医疗移植物产品，例如生长因子。 FGF-2。 优选的移植材料是从人或动物供体分离的细胞外基质材料，特别是含粘膜下层的细胞外基质材料。 进一步描述的是用于制备凝胶或可用于制备凝胶的ECM组合物，以及相关的制备和使用方法。

公开(公告)号：US20070082060A1

公开(公告)日：2007-04-12

申请号：US10569218

申请日：2004-08-25

申请人： Michael Hiles ,  Jason Hodde ,  David Ernst ,  Lal Ninan

发明人： Michael Hiles ,  Jason Hodde ,  David Ernst ,  Lal Ninan

IPC分类号： A61K38/18 ,  A61K35/37

CPC分类号： A61L27/54 ,  A61K35/38 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3687 ,  A61L27/50 ,  A61L2300/414 ,  A61L2400/06

摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibrob-last Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.

摘要翻译： 描述了含有受控水平的生长因子如Fibrob-last Growth Factor-2（FGF-2）的包装的无菌医用移植物产品。 还描述了制造医疗移植产品的方法，其中控制和监测包括灭菌在内的处理以提供具有调节的已知水平的细胞外基质因子例如生长因子的医疗移植物产品，例如生长因子。 FGF-2。 优选的移植材料是从人或动物供体分离的细胞外基质材料，特别是含有细胞外基质材料的粘膜下层。 进一步描述的是用于制备凝胶或可用于制备凝胶的ECM组合物，以及相关的制备和使用方法。

公开(公告)号：US20070122390A1

公开(公告)日：2007-05-31

申请号：US11668908

申请日：2007-01-30

申请人： Jason Hodde ,  David Ernst

发明人： Jason Hodde ,  David Ernst

IPC分类号： A61K35/22

CPC分类号： A61L27/3687 ,  A61K35/22 ,  A61K35/38 ,  A61K35/42 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3641

摘要： Described are devices, methods, and systems for grafting tissues or organs that are exposed to bacterial or mammalian enzymes that degrade collagenous materials. Illustrative medical grafts are processed by contacting a collagenous extracellular matrix (ECM) material with a mono-carboxylic acid having from four to about twelve carbon atoms, or mixtures of two or more such acids.

摘要翻译： 描述了用于移植暴露于降解胶原材料的细菌或哺乳动物酶的组织或器官的装置，方法和系统。 通过使胶原细胞外基质（ECM）材料与具有四至约十二个碳原子的单羧酸或两种或多种这些酸的混合物接触来处理说明性的医用移植物。

公开(公告)号：US20070100363A1

公开(公告)日：2007-05-03

申请号：US11260639

申请日：2005-10-27

申请人： Michael Dollar ,  Victor Dubuclet ,  David Ernst

发明人： Michael Dollar ,  Victor Dubuclet ,  David Ernst

IPC分类号： A61B17/32

CPC分类号： A61B17/32053 ,  A61B17/0057 ,  A61B2017/1107

摘要： A system for making a precise incision and circular hole in a vessel wall, such as the aorta, that eliminates lateral side notches from the aortotomy. In one aspect, the system includes a surgical knife or lancet having a blade surrounded by a retractable shield. In one aspect, the system includes a tissue punch having a rotating circumferential edge for receiving a parabolic-shaped anvil having an anvil cutting edge. The anvil is placed through an incision made by a knife and actuated to produce a hole in the vessel wall.

摘要翻译： 用于在血管壁（例如主动脉）中进行精确切口和圆孔的系统，其消除了从主动脉切开术的侧面凹陷。 一方面，该系统包括具有由可伸缩护罩包围的刀片的外科手术刀或柳叶刀。 在一个方面，该系统包括具有旋转圆周边缘的组织冲头，用于接收具有砧座切割边缘的抛物线形砧座。 砧座通过由刀制成的切口放置，并致动以在血管壁中产生孔。

公开(公告)号：US09148680B1

公开(公告)日：2015-09-29

申请号：US13179218

申请日：2011-07-08

申请人： Elizabeth Rockwood Fulton ,  David Ernst ,  Steve Ozzano

发明人： Elizabeth Rockwood Fulton ,  David Ernst ,  Steve Ozzano

IPC分类号： H04N7/10 ,  H04N7/025 ,  H04N21/25 ,  H04N21/45

CPC分类号： H04N21/252 ,  H04N21/25883 ,  H04N21/2668 ,  H04N21/4532 ,  H04N21/6582 ,  H04N21/812 ,  H04N21/8456

摘要： Apparatus and methods for segmenting television audience data are disclosed. The methods include receiving program level viewing data for one or more individuals. The methods also include creating one or more segments for the one or more individuals based upon the program level viewing data. The methods further include combining the one or more segments into one or more groups by applying a grouping function and performing analysis on the one or more groups, and generating reports based upon the analysis.

摘要翻译： 公开了用于分割电视观众数据的装置和方法。 这些方法包括接收一个或多个个人的节目级别观看数据。 所述方法还包括基于节目级观看数据为一个或多个个人创建一个或多个片段。 所述方法还包括通过应用分组功能并对所述一个或多个组执行分析，并且基于分析生成报告来将所述一个或多个分段组合成一个或多个分组。