公开(公告)号：US20160282338A1

公开(公告)日：2016-09-29

申请号：US15033542

申请日：2014-10-30

申请人： Jason MIKLAS ,  Milica RADISIC ,  Nimalan THAVANDIRAN ,  Sara VASCONCELOS ,  Yun XIAO ,  Boyang ZHANG ,  Yimu ZHAO

发明人： Jason Miklas ,  Milica Radisic ,  Nimalan Thavandiran ,  Sara Vasconcelos ,  Yun Xiao ,  Boyang Zhang ,  Yimu Zhao

IPC分类号： G01N33/50 ,  C12M1/34 ,  C12M1/32 ,  C12M1/42 ,  C12M3/00 ,  C12M1/12

CPC分类号： G01N33/5082 ,  C12M21/08 ,  C12M23/12 ,  C12M23/16 ,  C12M25/14 ,  C12M35/02 ,  C12M41/46 ,  G01N33/502 ,  G01N33/5061

摘要： The present disclosure provides methods, compositions, and devices for making and using three-dimensional biological tissues that accurately mimic native physiology, architecture, and other properties of native tissues for use in, among other applications, drug testing, tissue repair and/or treatment, and regenerative medicine.

摘要翻译： 本公开提供了用于制造和使用三维生物组织的方法，组合物和装置，其精确地模拟天然组织的天然生理学，结构和其它性质，以用于除其他应用之外，药物测试，组织修复和/或治疗 和再生医学。

公开(公告)号：US10254274B2

公开(公告)日：2019-04-09

申请号：US15033542

申请日：2014-10-30

申请人： Jason Miklas ,  Milica Radisic ,  Nimalan Thavandiran ,  Sara Vasconcelos ,  Yun Xiao ,  Boyang Zhang ,  Yimu Zhao

发明人： Jason Miklas ,  Milica Radisic ,  Nimalan Thavandiran ,  Sara Vasconcelos ,  Yun Xiao ,  Boyang Zhang ,  Yimu Zhao

IPC分类号： G01N33/50 ,  C12M1/34 ,  C12M3/00 ,  C12M1/32 ,  C12M3/06 ,  C12M1/12 ,  C12M1/42

摘要： The present disclosure provides methods, compositions, and devices for making and using three-dimensional biological tissues that accurately mimic native physiology, architecture, and other properties of native tissues for use in, among other applications, drug testing, tissue repair and/or treatment, and regenerative medicine.

公开(公告)号：US20230075923A1

公开(公告)日：2023-03-09

申请号：US17798047

申请日：2020-02-07

申请人： Milica Radisic ,  Boyang Zhang ,  Yimu Zhao ,  Valo Health, Inc.

发明人： Milica Radisic ,  Boyang Zhang ,  Yimu Zhao ,  Keith Yeager

IPC分类号： C12M3/00 ,  C12M1/32 ,  C12M1/00 ,  C12M1/42

摘要： Embodiments described herein relate generally to devices, apparatuses, and systems with embedded electrodes for rowing, maintaining, and/or using 3D tissues in vitro. The devices, apparatuses, and systems described herein can provide scalable, automated tissue stimulation.

公开(公告)号：US20240133873A1

公开(公告)日：2024-04-25

申请号：US18537653

申请日：2023-12-12

申请人： Milica Radisic

发明人： Jason Miklas ,  Milica Radisic ,  Nimalan Thavandiran ,  Sara Vasconcelos ,  Yun Xiao ,  Boyang Zhang ,  Yimu Zhao

IPC分类号： G01N33/50 ,  C12M1/12 ,  C12M1/32 ,  C12M1/34 ,  C12M1/42 ,  C12M3/00 ,  C12M3/06

CPC分类号： G01N33/5082 ,  C12M21/08 ,  C12M23/12 ,  C12M23/16 ,  C12M25/14 ,  C12M35/02 ,  C12M41/46 ,  G01N33/502 ,  G01N33/5061

摘要： The present disclosure provides methods, compositions, and devices for making and using three-dimensional biological tissues that accurately mimic native physiology, architecture, and other properties of native tissues for use in, among other applications, drug testing, tissue repair and/or treatment, and regenerative medicine.

公开(公告)号：US11913940B2

公开(公告)日：2024-02-27

申请号：US16259399

申请日：2019-01-28

申请人： Milica Radisic

发明人： Jason Miklas ,  Milica Radisic ,  Nimalan Thavandiran ,  Sara Vasconcelos ,  Yun Xiao ,  Boyang Zhang ,  Yimu Zhao

IPC分类号： G01N33/50 ,  C12M3/00 ,  C12M1/32 ,  C12M3/06 ,  C12M1/12 ,  C12M1/42 ,  C12M1/34

CPC分类号： G01N33/5082 ,  C12M21/08 ,  C12M23/12 ,  C12M23/16 ,  C12M25/14 ,  C12M35/02 ,  C12M41/46 ,  G01N33/502 ,  G01N33/5061

摘要： The present disclosure provides methods, compositions, and devices for making and using three-dimensional biological tissues that accurately mimic native physiology, architecture, and other properties of native tissues for use in, among other applications, drug testing, tissue repair and/or treatment, and regenerative medicine.

公开(公告)号：US08634405B2

公开(公告)日：2014-01-21

申请号：US12555390

申请日：2009-09-08

申请人： Donald Richard Brown ,  H. Vincent Poor ,  Boyang Zhang

发明人： Donald Richard Brown ,  H. Vincent Poor ,  Boyang Zhang

IPC分类号： H04J1/00 ,  H04J3/06

CPC分类号： H04W56/001 ,  H04W56/0035

摘要： A system and method for synchronizing the phases and frequencies of devices in multi-user, wireless communications systems are provided. A primary beacon signal is transmitted by a destination node in a wireless communications network to a plurality of source nodes. Secondary beacon signals are also exchanged between the source nodes. Using the primary and secondary beacon signals, the nodes generate local phase and frequency estimates which are used to control local phases and frequencies of the source nodes. The source nodes then transmit common information to the destination at carrier frequencies based on the estimated local frequencies and phases, so that the phases and frequencies of the transmitted information are synchronized to facilitate coherent combining of the bandpass signals at the destination. Phase and frequency synchronization can be applied to wireless communications systems having any number of source nodes, and effects of Doppler shifts and moving platforms are accounted for. Acoustic and radio-frequency signaling can be utilized.

摘要翻译： 提供了一种用于在多用户，无线通信系统中同步设备的相位和频率的系统和方法。 主信标信号由无线通信网络中的目的地节点发送到多个源节点。 次信标信号也在源节点之间交换。 使用主信标信号和次信标信号，节点产生用于控制源节点的局部相位和频率的局部相位和频率估计。 源节点然后基于估计的本地频率和相位在载波频率上将公共信息发送到目的地，使得所发送的信息的相位和频率被同步以促进目的地的带通信号的相干组合。 相位和频率同步可以应用于具有任何数量的源节点的无线通信系统，并且考虑到多普勒频移和移动平台的影响。 可以使用声学和射频信号。

公开(公告)号：US20100103917A1

公开(公告)日：2010-04-29

申请号：US12555390

申请日：2009-09-08

申请人： Donald Richard Brown ,  H. Vincent Poor ,  Boyang Zhang

发明人： Donald Richard Brown ,  H. Vincent Poor ,  Boyang Zhang

IPC分类号： H04J1/00

CPC分类号： H04W56/001 ,  H04W56/0035

摘要： A system and method for synchronizing the phases and frequencies of devices in multi-user, wireless communications systems are provided. A primary beacon signal is transmitted by a destination node in a wireless communications network to a plurality of source nodes. Secondary beacon signals are also exchanged between the source nodes. Using the primary and secondary beacon signals, the nodes generate local phase and frequency estimates which are used to control local phases and frequencies of the source nodes. The source nodes then transmit common information to the destination at carrier frequencies based on the estimated local frequencies and phases, so that the phases and frequencies of the transmitted information are synchronized to facilitate coherent combining of the bandpass signals at the destination. Phase and frequency synchronization can be applied to wireless communications systems having any number of source nodes, and effects of Doppler shifts and moving platforms are accounted for. Acoustic and radio-frequency signaling can be utilized.

摘要翻译： 提供了一种用于在多用户，无线通信系统中同步设备的相位和频率的系统和方法。 主信标信号由无线通信网络中的目的地节点发送到多个源节点。 次信标信号也在源节点之间交换。 使用主信标信号和次信标信号，节点产生用于控制源节点的局部相位和频率的局部相位和频率估计。 源节点然后基于估计的本地频率和相位在载波频率上将公共信息发送到目的地，使得所发送的信息的相位和频率被同步以促进目的地的带通信号的相干组合。 相位和频率同步可以应用于具有任何数量的源节点的无线通信系统，并且考虑到多普勒频移和移动平台的影响。 可以使用声学和射频信号。