摘要:
The present disclosure provides methods, compositions, and devices for making and using three-dimensional biological tissues that accurately mimic native physiology, architecture, and other properties of native tissues for use in, among other applications, drug testing, tissue repair and/or treatment, and regenerative medicine.
摘要:
A method of controlling airflow of an engine system is provided. The method includes determining a supercharger operating mode and a turbocharger operating mode based on engine load; selectively generating a control signal to a turbocharger based on the turbocharger operating mode; and selectively generating a control signal to a supercharger bypass valve based on the supercharger operating mode.
摘要:
A bus stop board for advertising includes a communicating unit, a storage unit, an input unit, a control unit, a display unit, and a short message service control unit. The control unit obtains available advertisements stored in the storage unit in response to a passenger's first signal into the input unit, and receives a selection of advertisements made by a passenger in response to a second signal. The display unit displays the selected advertisements and a user interface for the passenger's telephone number. The short message service control unit generates a data package for each selected advertisement and transmits the data package to a user terminal with the input telephone number. A related system is also provided.
摘要:
A bus stop sign capable of providing detailed bus schedules includes a storage unit, a detecting unit, a communicating unit, and a control unit. The storage unit pre-stores a table recording identifications of a plurality of mobile terminals, identifications of a plurality of bus terminals, and stop information of the bus stop sign along bus routes of the bus terminals. If the identifications of the mobile terminals obtained by the detecting unit match one or more identifications recorded in the table, the control unit obtains identifications of bus terminals recorded in the table corresponding to the obtained identifications, and controls the communicating unit to transmit the obtained identifications to the server. The server determines the current location of the nearest bus terminal travelling toward the bus stop sign and feeds back the current location of the nearest bus terminal to the mobile terminal. A related sever is also provided.
摘要:
A method for printing and faxing is used for an electronic device storing a relationship table. The relationship table records a mapping relationship between touch input and a plurality of commands. The method comprises the following steps. Display an electronic file selected by a user. Then generate signals in response to user's touch input on the displayed electronic file. Determine whether a command associated with the touch input of the user is a printing command or a fax command according to the generated signals and the relationship table. Retrieve circled content of the displayed electronic file circled by the user when the command associated with the touch input of the user is the printing command or the fax command; and send the circled content to a printer or send the circled content to a fax machine selected by the user. An electronic device using the method is also provided.
摘要:
A method of controlling a diesel engine includes sensing a speed of the diesel engine, and closing a throttle of the diesel engine when the sensed speed of the diesel engine is equal to or greater than a maximum allowable engine speed to prevent oxygen from entering an intake manifold of the diesel engine, thereby preventing combustion and stopping the operation of the diesel engine. An Exhaust Gas Recirculation (EGR) valve is actuated to regulate circulation of exhaust gas from the diesel engine through the intake manifold to control pressure within the intake manifold to prevent damage to other engine components from excessive positive or negative pressure.
摘要:
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I), its enantiomers, diastereomers, or a pharmaceutically acceptable salt, or hydrate, thereof, wherein X is (Ia); or X is (Ib); or X is (Ic); (Id) is heterocycle or heteroaryl; E is —N—, —NR1—, —O—, —S—, —SO2— or —CR2—; F is —N—, —NR1a—, —O—, —S—, —SO2— or —CR2a—; G is N, —NR1b—, —O—, —S—, —SO2— or —CR2b—, provided that the E-F-G containing heterocyclic ring formed does not contain a S—S or S—O bond, and at least one of E, F and G is a heteroatom; J, Ja, M, Ma, Q, Rx, Ry, R1, R1a, R1b, R2, R2a, R2b, and R3 to R21, Z, Za, Zb, and Zc are as defined above.
摘要翻译:提供了新的非甾体化合物,其可用于治疗与调节糖皮质激素受体,AP-1和/或NF-κB活性相关的疾病,包括具有式(I)结构的炎性和免疫疾病,肥胖症和糖尿病 ),其对映异构体,非对映异构体或其药学上可接受的盐或水合物,其中X为(Ia); 或X为(Ib); 或X为(Ic); (Id)是杂环或杂芳基; E是-N-,-NR1 - , - O - , - S - , - SO2-或-CR2-; F是-N-,-NR1 - , - O - , - S - , - SO2-或-CR2a-; G是N,-NR1b - , - O - , - S - , - SO2-或-CR2b-,条件是所形成的含有EFG的杂环不含S-S或S-O键, E,F和G是杂原子; J,Ja,M,Ma,Q,Rx,Ry,R1,R1a,R1b,R2,R2a,R2b和R3至R21,Z,Za,Zb和Zc如上所定义。
摘要:
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, and/or AP-1 and/or NF-κB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I): its enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, wherein the group X is O or (Rx)(Ry); is heterocyclo or heteroaryl; E is —N—, —NR1—, —O—, —C(═O), —S—, —SO2—, or —CR2—; F is —N—, —NR1a, —O—, —C(═O), —S—, —SO2—, or —CR2a—; G is independently N, —NR1b—, —O—, —C(═O), —S—, —SO2— or —CR2b— provided that the heterocyclic ring formed does not contain a S—S or S—O bond and at least one of E, F and G is a hetero atom; and Ma, Rx, Ry, R1, R1a, R1b, R2, R2a, R2b, R4, R5a, R6, R7, X, Za and Z are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases employing said compounds.
摘要:
A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) or (II): including a stereoisomer thereof, a tautomer thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Q is selected from N, O, and S; Y is aryl or heteroaryl; Z is H, C2-6alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, or alkoxy; and A, B, R, Ra, Rb, Rc and Rd are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
摘要:
Tricycloundecanes compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds are disclosed.