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1.发明授权
公开(公告)号：US5081226A
公开(公告)日：1992-01-14
申请号：US492318
申请日：1990-02-28
申请人： Jay A. Berzofsky , Charles DeLisi , Hanah Margalit , James L. Cornette , Kemp B. Cease , Cecilia S. Ouyang
发明人： Jay A. Berzofsky , Charles DeLisi , Hanah Margalit , James L. Cornette , Kemp B. Cease , Cecilia S. Ouyang
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
摘要： This invention relates to the identification of short peptide segments of AIDS virus proteins which elicit T cellular immunity, and to a method of inducing cellular immunity to native proteins of the AIDS virus by immunization with short synthetic peptides. Five potential peptides have been identified by searching for regions which can fold as a maximally amphipathic helix. These may be useful to include in either a synthetic peptide- or recombinant fragment- based vaccine.
摘要翻译： 本发明涉及鉴定引起T细胞免疫的AIDS病毒蛋白质的短肽段，以及通过用短合成肽免疫诱导AIDS病毒天然蛋白质的细胞免疫的方法。 已经通过搜索可以折叠成最大两亲性螺旋的区域来鉴定五种潜在的肽。 这些可能有助于包括在基于合成肽或重组片段的疫苗中。
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公开(公告)号：US5030449A
公开(公告)日：1991-07-09
申请号：US222684
申请日：1988-07-21
申请人： Jay A. Berzofsky , Paula M. Hale , Anne Hosmalin , Hanah Margalit , John L. Spouge , James L. Cornette
发明人： Jay A. Berzofsky , Paula M. Hale , Anne Hosmalin , Hanah Margalit , John L. Spouge , James L. Cornette
IPC分类号： G01N33/569 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K7/08 , C07K14/155 , C07K14/16
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122 , Y10S930/221
摘要： The invention relates to peptide antigens which stimulate helper T lympocytes which specifically recognize HIV envelope protein, thereby enhancing antibody production and cytotoxic T cells to inhibit expression of an infection caused by HIV virus.
摘要翻译： 本发明涉及刺激特异性识别HIV包膜蛋白的辅助性T淋巴细胞的肽抗原，从而增强抗体产生和细胞毒性T细胞以抑制由HIV病毒引起的感染的表达。
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公开(公告)号：US5583973A
公开(公告)日：1996-12-10
申请号：US123556
申请日：1993-09-17
CPC分类号： G06T15/405 , G06T17/00
摘要： A method, performed on a computer (10), for generating representations of a molecule, both two- and three-dimensional, is provided. The method includes establishing X, Y, and Z coordinate axes for the molecule to be modeled such that a rectangular region is established with sides parallel to the coordinate axes. The method also includes establishing a grid of coordinates on the X, Y, and Z coordinates axes with a grid mesh size of sufficient resolution to identify atom points of the molecule and solvent points. Next, the method includes identifying surface points which form a trace in one dimension in each Z cross-section, and generating tracing instructions for each Z cross-section by tracing along the surface points in the trace in each Z cross-section and writing the X, Y coordinates to instructions for controlling a computer display or for controlling a computer controlled milling machine. The method also includes generating on a computer display a two-dimensional grid and surface geometry for the molecule including atom identifications using the tracing steps for each Z cross-section. Additionally, the method includes cutting sheets representative of each Z cross-section with the milling instructions and assembling the sheets into three-dimensional models representative of the molecule.
摘要翻译： 提供了一种在计算机（10）上执行的用于产生二维和三维分子的表示的方法。 该方法包括为要被建模的分子建立X，Y和Z坐标轴，使得建立与平行于坐标轴的边的矩形区域。 该方法还包括在具有足够分辨率的网格网格尺寸的X，Y和Z坐标轴上建立坐标网格，以识别分子和溶剂点的原子点。 接下来，该方法包括识别在每个Z横截面中在一个维度上形成轨迹的表面点，以及通过沿着每个Z横截面中的轨迹中的表面点进行跟踪来生成针对每个Z横截面的跟踪指令，并写入 X，Y坐标到用于控制计算机显示器或用于控制计算机控制的铣床的指令。 该方法还包括在计算机上生成用于分子的二维网格和表面几何，包括使用每个Z横截面的跟踪步骤的原子标识。 此外，该方法包括用铣削指令切割代表每个Z横截面的片材，并将片材组装成代表该分子的三维模型。
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公开(公告)号：US5495423A
公开(公告)日：1996-02-27
申请号：US142597
申请日：1993-10-25
摘要： A method for computing the conformation and location that a protein fragment will obtain in binding to the active site of a receptor is provided. The invention relates to both the computation of conformation and location of natural ligands within an active site and the design of artificial ligands with useful binding characteristics.
摘要翻译： 提供了一种用于计算蛋白质片段在与受体的活性位点结合时将获得的构象和位置的方法。 本发明涉及构象的计算和活性位点内天然配体的定位以及具有有用结合特征的人造配体的设计。
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