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公开(公告)号：US06291677B1
公开(公告)日：2001-09-18
申请号：US09651001
申请日：2000-08-29
IPC分类号： C07D21514
CPC分类号： C07D221/20 , C07C59/72 , C07C65/28 , C07D215/14 , C07D217/04 , C07D311/58
摘要： Compounds having Formula 7 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
摘要翻译： 具有式7的化合物，其中符号具有本说明书中定义的含义是细胞色素P450RAI（视黄酸诱导型）酶的抑制剂，并且用于治疗响应于类视黄醇治疗的疾病。
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公开(公告)号：US06369225B1
公开(公告)日：2002-04-09
申请号：US09651566
申请日：2000-08-29
IPC分类号： C07C6916
摘要： Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
摘要翻译： 具有式8的化合物，其中符号具有本说明书中定义的含义是细胞色素P450RAI（视黄酸诱导型）酶的抑制剂，并且用于治疗响应于类视黄醇治疗的疾病。
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公开(公告)号：US06359135B1
公开(公告)日：2002-03-19
申请号：US09829098
申请日：2001-04-09
IPC分类号： C07D21514
CPC分类号： C07D221/20 , A61K31/192 , A61K31/195 , A61K31/353 , A61K31/382 , A61K31/47 , A61K31/472 , A61K31/4747 , C07C59/72 , C07C65/28 , C07D215/14 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D311/96 , C07D333/40 , C07D335/04 , C07D335/06 , C07D409/06
摘要： Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
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公开(公告)号：US06252090B1
公开(公告)日：2001-06-26
申请号：US09651235
申请日：2000-08-29
IPC分类号： C09B2922
CPC分类号： C07D221/20 , A61K31/192 , A61K31/195 , A61K31/353 , A61K31/382 , A61K31/47 , A61K31/472 , A61K31/4747 , C07C59/72 , C07C65/28 , C07D215/14 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D311/96 , C07D333/40 , C07D335/04 , C07D335/06 , C07D409/06
摘要： Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
摘要翻译： 具有式1的化合物，其中符号具有本说明书中定义的含义是细胞色素P450RAI（视黄酸诱导型）酶的抑制剂，并且用于治疗响应于类视黄醇治疗的疾病。
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公开(公告)号：US06531599B2
公开(公告)日：2003-03-11
申请号：US10004914
申请日：2001-12-05
IPC分类号： C07D23708
CPC分类号： C07D221/20 , A61K31/192 , A61K31/195 , A61K31/353 , A61K31/382 , A61K31/47 , A61K31/472 , A61K31/4747 , C07C59/72 , C07C65/28 , C07D215/14 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D311/96 , C07D333/40 , C07D335/04 , C07D335/06 , C07D409/06
摘要： Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
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公开(公告)号：US06855512B2
公开(公告)日：2005-02-15
申请号：US10212533
申请日：2002-08-05
IPC分类号： C07D233/60 , A61K31/167 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/216 , A61K31/232 , A61K31/24 , A61K31/353 , A61K31/381 , A61K31/382 , A61K31/4174 , A61K31/47 , A61K31/472 , A61K31/4747 , A61P1/04 , A61P3/02 , A61P3/06 , A61P3/10 , A61P5/06 , A61P5/10 , A61P5/38 , A61P7/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/12 , A61P17/14 , A61P17/16 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/12 , A61P31/20 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P39/00 , A61P43/00 , C07C59/64 , C07C59/72 , C07C59/86 , C07C65/28 , C07C65/38 , C07C69/757 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C403/20 , C07D215/14 , C07D217/04 , C07D221/20 , C07D311/58 , C07D311/70 , C07D311/96 , C07D333/40 , C07D335/04 , C07D335/06 , C07D409/06 , C07D521/00 , C12Q1/26
CPC分类号： C07D221/20 , A61K31/192 , A61K31/195 , A61K31/353 , A61K31/382 , A61K31/47 , A61K31/472 , A61K31/4747 , C07C59/72 , C07C65/28 , C07D215/14 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D311/70 , C07D311/96 , C07D333/40 , C07D335/04 , C07D335/06 , C07D409/06
摘要： A method of identifying a compound which is an inhibitor of the enzyme cytochrome P450RAI is performed by selecting a compound that has retinoid activity in an art recognized assay and includes a benzoic acid, benzoic acid ester, naphthoic acid ester or heteroaryl carboxylic acid or ester moiety, with a partial structure of —A(R2)—(CH2)n—COOR8 where n is 0 and the remaining variables are as described in the specification and claims. Thereafter, a compound having the cytochrome P450RAI inhibitory activity is identified and selected where the compound has the —A(R2)—(CH2)2—COOR8 partial structure wherein the variable n is 1 or 2.
摘要翻译： 鉴定作为细胞色素P450RAI酶的抑制剂的化合物的方法通过在本领域公认的测定中选择具有类视黄醇活性的化合物进行，并且包括苯甲酸，苯甲酸酯，萘甲酸酯或杂芳基羧酸或酯部分 ，其具有-A（R2） - （CH2）n-COOR8的部分结构，其中n为0，其余变量如说明书和权利要求中所述。 此后，鉴定并选择具有细胞色素P450RAI抑制活性的化合物，其中化合物具有其中n为1或2的-A（R 2） - （CH 2）2 -COOR 8部分结构。
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7.发明授权公开(公告)号：US06495552B2
公开(公告)日：2002-12-17
申请号：US09963318
申请日：2001-06-07
IPC分类号： A61K31495
CPC分类号： C07D221/20 , A61K31/192 , A61K31/195 , A61K31/353 , A61K31/382 , A61K31/47 , A61K31/472 , A61K31/4747 , C07C59/72 , C07C65/28 , C07D215/14 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D311/70 , C07D311/96 , C07D333/40 , C07D335/04 , C07D335/06 , C07D409/06
摘要： Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. The compound can also be used in co-treatment with retinoids.
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公开(公告)号：US06399774B1
公开(公告)日：2002-06-04
申请号：US09829097
申请日：2001-04-09
IPC分类号： C07D23702
CPC分类号： C07D221/20 , A61K31/192 , A61K31/195 , A61K31/353 , A61K31/382 , A61K31/47 , A61K31/472 , A61K31/4747 , C07C59/72 , C07C65/28 , C07D215/14 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D311/96 , C07D333/40 , C07D335/04 , C07D335/06 , C07D409/06
摘要： Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
摘要翻译： 具有式1的化合物，其中符号具有本说明书中定义的含义是细胞色素P450RAI（视黄酸诱导型）酶的抑制剂，并且用于治疗响应于类视黄醇治疗的疾病。
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公开(公告)号：US06387951B1
公开(公告)日：2002-05-14
申请号：US09651234
申请日：2000-08-29
IPC分类号： A61K31192
摘要： Compounds having Formulas 5 and 6 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
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10.发明授权Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI 失效提供和使用具有活性的化合物作为细胞色素P450RAI抑制剂的方法公开(公告)号：US06387892B1
公开(公告)日：2002-05-14
申请号：US09875967
申请日：2001-06-07
IPC分类号： A61K31655
CPC分类号： C07D221/20 , A61K31/192 , A61K31/195 , A61K31/353 , A61K31/382 , A61K31/47 , A61K31/472 , A61K31/4747 , C07C59/72 , C07C65/28 , C07D215/14 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D311/70 , C07D311/96 , C07D333/40 , C07D335/04 , C07D335/06 , C07D409/06
摘要： Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. The compound can also be used in co-treatment with retinoids.
摘要翻译： 具有式1至8的新化合物，其中符号具有说明书中定义的含义，并且已经发现某些先前已知的化合物作为细胞色素P450RAI（视黄酸诱导型）酶的抑制剂，并用于治疗疾病反应性 由维甲酸治疗。 该化合物也可用于与类维生素A的共处理。
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