公开(公告)号：US20240360081A1

公开(公告)日：2024-10-31

申请号：US18571860

申请日：2022-06-24

申请人： Jazz Pharmaceuticals Ireland Limited

发明人： Davide MARINELLI ,  Prafulkumar Chovatia ,  Claudia BEATO ,  Gilles OUVRY

IPC分类号： C07D213/64 ,  A61K31/415 ,  A61K31/4192 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4704 ,  A61K31/506 ,  A61K31/513 ,  C07D213/84 ,  C07D215/227 ,  C07D231/12 ,  C07D239/36 ,  C07D249/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D471/04

CPC分类号： C07D213/64 ,  A61K31/415 ,  A61K31/4192 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4704 ,  A61K31/506 ,  A61K31/513 ,  C07D213/84 ,  C07D215/227 ,  C07D231/12 ,  C07D239/36 ,  C07D249/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D471/04

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, A, L1, L2, Y and Z are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of a disease or disorder that is treatable by administration of an Orexin agonist.

公开(公告)号：US20240254143A1

公开(公告)日：2024-08-01

申请号：US18558245

申请日：2022-05-03

申请人： JAZZ PHARMACEUTICALS IRELAND LIMITED

发明人： Prafulkumar CHOVATIA ,  Claudia BEATO ,  Gilles OUVRY ,  Davide MARINELLI

IPC分类号： C07D498/10 ,  C07D471/10 ,  C07D513/10 ,  C07D515/10

CPC分类号： C07D498/10 ,  C07D471/10 ,  C07D513/10 ,  C07D515/10

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein n, m, A1, A2, A3, A4, A5, A6, L1, L2, R1, R2, R3, Y and Z are defined herein. Also provided herein are pharmaceutical compositions comprising a compound N of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of a disease or disorder that is treatable by administration of an Orexin agonist.