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14 条记录 (耗时 0.029 秒)

    Anti-cancer activity of novel bicyclic heterocycles
    6.
    发明授权
    Anti-cancer activity of novel bicyclic heterocycles 有权
    新型双环杂环的抗癌活性

    公开(公告)号：US09573966B2

    公开(公告)日：2017-02-21

    申请号：US13823413

    申请日：2011-09-08

    申请人： Jean Herman ,  Thierry Louat

    发明人： Jean Herman ,  Thierry Louat

    IPC分类号： A61K31/519 ,  C07D513/04 ,  C07D495/04 ,  C07D473/32 ,  C07D498/04

    CPC分类号： C07D513/04 ,  A61K31/519 ,  C07D473/32 ,  C07D495/04 ,  C07D498/04

    摘要： The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, Formulas (I), (II), (III) and (IV) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent proliferative disorders and their use to manufacture a medicine to treat or prevent proliferative disorders, particularly cancer such as leukemia. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent proliferative disorders. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of proliferative disorders and pathologic conditions such as, but not limited to, cancer such as leukemia.

    摘要翻译： 本发明涉及式I，II，III或IV的化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂化物，式（I），（II），（III ）和（IV）其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 11和R 12如权利要求1中所定义或如在本发明的说明书中详细描述的， 使用所述化合物治疗或预防增殖性疾病及其用于制造药物以治疗或预防增殖性疾病，特别是诸如白血病的癌症。 本发明还涉及所述化合物的药物组合物和所述药物组合物用于治疗或预防增殖性疾病的用途。 本发明还涉及所述化合物作为生物活性成分的用途，更具体地说，涉及用于治疗增殖性疾病和病理状况（例如但不限于）诸如白血病的癌症的药物。

    Antiviral Activity of Novel Bicyclic Heterocycles
    8.
    发明申请
    Antiviral Activity of Novel Bicyclic Heterocycles 有权
    新型双环杂环的抗病毒活性

    公开(公告)号：US20160030447A1

    公开(公告)日：2016-02-04

    申请号：US14884997

    申请日：2015-10-16

    申请人： Steven De Jonghe ,  Ling-Jie Gao ,  Piet Herdewijn ,  Jean Herman ,  Miyeon Jang ,  Pieter Leyssen ,  Thierry Louat ,  Johan Neyts ,  Christophe Pannecouque ,  Bart Vanderhoydonck

    发明人： Steven De Jonghe ,  Ling-Jie Gao ,  Piet Herdewijn ,  Jean Herman ,  Miyeon Jang ,  Pieter Leyssen ,  Thierry Louat ,  Johan Neyts ,  Christophe Pannecouque ,  Bart Vanderhoydonck

    IPC分类号： A61K31/551 ,  A61K31/5377 ,  A61K31/519

    CPC分类号： A61K31/551 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  C07D473/00 ,  C07D513/04 ,  Y02A50/385 ,  Y02A50/465

    摘要： The present invention relates to compound of Formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with RNA-viruses belonging to the family of the Retroviridae, the family of the Flaviviridae and the family of the Picornaviridae and more preferably infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HN2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of viral disorders and pathologic conditions such as, but not limited to, viral infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HN2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovints.

    摘要翻译： 本发明涉及式I，II，III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物，其中R1，R2，R3，R4，R5， R6，R7，R8，R9，R11和R12如权利要求1中所定义或如在本发明的描述中详细描述的，以及所述化合物用于治疗或预防病毒感染及其用于制造 治疗或预防病毒感染的药物，特别是属于逆转录病毒科的家族，微病毒科的家族和小核糖核酸病毒科家族的RNA病毒的感染，更优选人免疫缺陷病毒1（HIV1），人类免疫缺陷病毒2 （HN2），丙型肝炎病毒（HCV），登革热病毒和诸如柯萨奇病毒，鼻病毒和脊髓灰质炎病毒的肠道病毒。 本发明还涉及所述化合物的药物组合物和所述药物组合物用于治疗或预防病毒感染的用途。 本发明还涉及所述化合物作为生物活性成分的用途，更具体地说，作为治疗病毒性病症和病理状况的药物，例如但不限于人免疫缺陷病毒1（HIV1），人类免疫缺陷病毒 病毒2（HN2），丙型肝炎病毒（HCV），登革热病毒和诸如柯萨奇病毒，鼻病毒和Poliovints的肠道病毒。