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公开(公告)号：US07485663B2
公开(公告)日：2009-02-03
申请号：US11217643
申请日：2005-08-31
申请人： Jean Hildesheim , Sergey Finogueev , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , IIan Kor
发明人： Jean Hildesheim , Sergey Finogueev , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , IIan Kor
IPC分类号： A61K31/403 , C07C209/82
CPC分类号： C07D209/88
摘要： This invention relates to an improved process of preparing carvedilol, as well as a new crystalline hydrate and solvate and forms of carvedilol, processes for the manufacture thereof, and pharmaceutical compositions thereof.
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公开(公告)号：US20060030614A1
公开(公告)日：2006-02-09
申请号：US11217643
申请日：2005-08-31
申请人： Jean Hildesheim , Sergey Finogueev , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , Iian Kor
发明人： Jean Hildesheim , Sergey Finogueev , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , Iian Kor
IPC分类号： A61K31/403 , C07D209/82
CPC分类号： C07D209/88
摘要： This invention relates to an improved process of preparing carvedilol, as well as a new crystalline hydrate and solvate and forms of carvedilol, processes for the manufacture thereof, and pharmaceutical compositions thereof.
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公开(公告)号：US20080194838A1
公开(公告)日：2008-08-14
申请号：US12148070
申请日：2008-04-15
申请人： Jean Hildesheim , Sergey Finogueev , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , Ilan Kor
发明人： Jean Hildesheim , Sergey Finogueev , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , Ilan Kor
IPC分类号： C07D209/82
CPC分类号： C07D209/88
摘要： This invention relates to an improved process of preparing carvedilol, as well as a new crystalline hydrate and solvate and forms of carvedilol, processes for the manufacture thereof, and pharmaceutical compositions thereof.
摘要翻译： 本发明涉及一种改进的卡维地洛的制备方法，以及新的结晶水合物和卡维地洛的溶剂化物和形式，其制备方法及其药物组合物。
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公开(公告)号：US07056942B2
公开(公告)日：2006-06-06
申请号：US10758025
申请日：2004-01-16
申请人： Jean Hildesheim , Sergey Finogueev , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , Ilan Kor
发明人： Jean Hildesheim , Sergey Finogueev , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , Ilan Kor
IPC分类号： C07D209/82 , A61K31/403
CPC分类号： C07D209/88
摘要： This invention relates to an improved process of preparing carvedilol, as well as a new crystalline hydrate and solvate and forms of carvedilol, processes for the manufacture thereof, and pharmaceutical compositions thereof.
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公开(公告)号：US20090326033A1
公开(公告)日：2009-12-31
申请号：US12584205
申请日：2009-09-01
IPC分类号： A61K31/403 , C07D209/88 , A61P9/12
CPC分类号： C07D209/88
摘要： This invention relates to an improved process of preparing carvedilol, as well as a new crystalline hydrate and solvate and forms of carvedilol, processes for the manufacture thereof, and pharmaceutical compositions thereof.
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公开(公告)号：US07126008B2
公开(公告)日：2006-10-24
申请号：US10758026
申请日：2004-01-16
申请人： Jean Hildesheim , Sergey Finogueev , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , Ilan Kor
发明人： Jean Hildesheim , Sergey Finogueev , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , Ilan Kor
IPC分类号： C07D209/82
CPC分类号： C07D209/88
摘要： This invention relates to an improved process of preparing carvedilol, as well as a new crystalline hydrate and solvate and forms of carvedilol, processes for the manufacture thereof, and pharmaceutical compositions thereof.
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公开(公告)号：US06699997B2
公开(公告)日：2004-03-02
申请号：US09894798
申请日：2001-06-28
IPC分类号： C07D20982
CPC分类号： C07D209/88
摘要： This invention relates to an improved process of preparing carvedilol, as well as a new crystalline hydrate and solvate and forms of carvedilol, processes for the manufacture thereof, and pharmaceutical compositions thereof.
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公开(公告)号：US07605274B2
公开(公告)日：2009-10-20
申请号：US12148070
申请日：2008-04-15
申请人： Jean Hildesheim , Sergei Fine , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , Ilan Kor-Sade
发明人： Jean Hildesheim , Sergei Fine , Judith Aronhime , Ben-Zion Dolitzky , Shoshana Ben-Valid , Ilan Kor-Sade
IPC分类号： A61K31/403 , C07D209/82
CPC分类号： C07D209/88
摘要： This invention relates to an improved process of preparing carvedilol, as well as a new crystalline hydrate and solvate and forms of carvedilol, processes for the manufacture thereof, and pharmaceutical compositions thereof.
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公开(公告)号：US20090156813A1
公开(公告)日：2009-06-18
申请号：US12315867
申请日：2008-12-04
申请人： Judith Aronhime , Ben-Zion Dolitzky , Eran Luvchick , Jean Hildesheim , Hagit Eisen-Nevo , Reuven Izsak
发明人： Judith Aronhime , Ben-Zion Dolitzky , Eran Luvchick , Jean Hildesheim , Hagit Eisen-Nevo , Reuven Izsak
IPC分类号： C07D401/12
CPC分类号： C07D215/227 , A61K31/496
摘要： The invention encompasses aripiprazole crystalline forms, methods of preparing the same, and pharmaceutical compositions having aripiprazole crystalline forms.
摘要翻译： 本发明包括阿立哌唑晶形，其制备方法和具有阿立哌唑结晶形式的药物组合物。
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公开(公告)号：US20050203299A1
公开(公告)日：2005-09-15
申请号：US11015068
申请日：2004-12-16
申请人： Judith Aronhime , Ben-Zion Dolitzky , Eran Luvchick , Jean Hildesheim , Hagit Eisen-Nevo , Reuven Izsak
发明人： Judith Aronhime , Ben-Zion Dolitzky , Eran Luvchick , Jean Hildesheim , Hagit Eisen-Nevo , Reuven Izsak
IPC分类号： A61K31/496 , C07D215/22 , C07D215/227 , C07D487/00
CPC分类号： C07D215/227 , A61K31/496
摘要： The invention encompasses aripiprazole crystalline forms, methods of preparing the same, and pharmaceutical compositions having aripiprazole crystalline forms.
摘要翻译： 本发明包括阿立哌唑晶形，其制备方法和具有阿立哌唑结晶形式的药物组合物。
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