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    1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them
    9.
    发明授权
    1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them 失效
    1-N-苯基氨基-1H-咪唑衍生物作为芳香酶抑制剂和含有它们的药物组合物

    公开(公告)号：US06737433B1

    公开(公告)日：2004-05-18

    申请号：US10319840

    申请日：2002-12-16

    申请人： Nathalie Adje ,  Paule Bonnet ,  Denis Carniato ,  Remi Delansorne ,  Jean Lafay ,  Jean-Claude Pascal

    发明人： Nathalie Adje ,  Paule Bonnet ,  Denis Carniato ,  Remi Delansorne ,  Jean Lafay ,  Jean-Claude Pascal

    IPC分类号： A61K314164

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Imidazole derivatives of the formula: in which R1 and R2 are each independently hydrogen, (C1-C6)alkyl or (C3-C8)cycloalkyl; n is 0, 1 or 2; R3, R4, R5 and R6 are each independently hydrogen or a (C1-C6)alkyl, halogen, cyano, (C1-C6)alkoxy, trifluoromethyl, (C1-C6)alkylthio, (C1-C6)alkylsulfonyl, sulfonamido, acyl, (C1-C6)alkoxycarbonyl, or carboxamido group; R3 and R6 together with the phenyl ring bearing them can also form a benzofurane, or a N-methylbenzotriazole. The invention also relates to pharmaceutical compositions containing these derivatives, and to the uses thereof.

    摘要翻译： 下式的咪唑衍生物：其中R 1和R 2各自独立地为氢，（C 1 -C 6）烷基或（C 3 -C 8）环烷基; n为0,1或2; R 3，R 4，R 5和R 6各自独立地为氢或 （C1-C6）烷基，卤素，氰基，（C1-C6）烷氧基，三氟甲基，（C1-C6）烷硫基，（C1-C6）烷基磺酰基，亚磺酰氨基，酰基，（C1-C6）烷氧基羰基或甲酰氨基; R3 和R6与带有它们的苯环一起也可以形成苯并呋喃或N-甲基苯并三唑。 本发明还涉及含有这些衍生物的药物组合物及其用途。