-
1.发明授权1-N-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them 失效1-N-苯基 - 氨基-1h-咪唑衍生物和含有它们的药物组合物公开(公告)号：US08476455B2
公开(公告)日：2013-07-02
申请号：US10582778
申请日：2004-12-15
申请人： Jean Lafay , Benoit Rondot , Paule Bonnet , Thierry Clerc , Jacqueline Shields , Igor Duc , Eric Duranti , Francois Puccio , Christian Blot , Philippe Maillos
发明人： Jean Lafay , Benoit Rondot , Paule Bonnet , Thierry Clerc , Jacqueline Shields , Igor Duc , Eric Duranti , Francois Puccio , Christian Blot , Philippe Maillos
IPC分类号： C07D233/44 , A61K31/4164
CPC分类号： C07D233/54 , C07D409/12 , C07D419/12
摘要： The invention relates to the compounds of formula (I): in which R1, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2，R3，R4，Q和Z如说明书中所定义。 本发明还涉及含有这些化合物的药物组合物。
-
2.发明申请INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS 失效丁唑，苯唑沙和苯并噻唑及其作为雌激素的用途公开(公告)号：US20110237624A1
公开(公告)日：2011-09-29
申请号：US13152433
申请日：2011-06-03
申请人： Benoit RONDOT , Jean LAFAY , Paule BONNET , Thierry CLERC , Igor DUC , Eric DURANTI , François PUCCIO , Jacqueline SHIELDS , Christian BLOT , Philippe MAILLOS
发明人： Benoit RONDOT , Jean LAFAY , Paule BONNET , Thierry CLERC , Igor DUC , Eric DURANTI , François PUCCIO , Jacqueline SHIELDS , Christian BLOT , Philippe MAILLOS
IPC分类号： A61K31/454 , C07D231/56 , C07D401/06 , C07D261/20 , C07D413/12 , C07D275/04 , A61K31/416 , A61K31/423 , A61K31/428 , A61P35/00 , A61P19/10 , A61P15/00 , A61P25/24
CPC分类号： C07D231/56 , C07D261/20 , C07D275/04 , C07D275/06 , C07D491/06
摘要： The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification.The compounds are modulators of the estrogen receptors.
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2，R3，X，Y和A如说明书中所定义。 这些化合物是雌激素受体的调节剂。
-
3.发明申请Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents 有权吲唑，苯并异恶唑和苯并异噻唑及其作为雌激素剂的用途公开(公告)号：US20090023779A1
公开(公告)日：2009-01-22
申请号：US11664887
申请日：2005-10-14
申请人： Benoit Rondot , Jean Lafay , Paule Bonnet , Thierry Clerc , Igor Duc , Eric Duranti , Francois Puccio , Jacqueline Shields , Christian Blot , Philippe Maillos
发明人： Benoit Rondot , Jean Lafay , Paule Bonnet , Thierry Clerc , Igor Duc , Eric Duranti , Francois Puccio , Jacqueline Shields , Christian Blot , Philippe Maillos
IPC分类号： C07D231/56 , A61K31/416 , C07D413/02 , A61K31/454 , A61K31/42 , C07D261/20 , C07D275/04 , A61K31/428 , A61P35/00
CPC分类号： C07D231/56 , C07D261/20 , C07D275/04 , C07D275/06 , C07D491/06
摘要： The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification.The compounds are modulators of the estrogen receptors.
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2，R3，X，Y和A如说明书中所定义。 这些化合物是雌激素受体的调节剂。
-
4.发明授权Derivatives of terbutylphenyl-1-amino-4-hydroxybutane their preparation processes and the pharmaceutical compositions containing them 失效三丁基苯基-1-氨基-4-羟基丁烷的衍生物及其制备方法和含有它们的药物组合物
公开(公告)号：US5461059A
公开(公告)日：1995-10-24
申请号：US861816
申请日：1993-03-26
申请人： Paule Bonnet , Remi Delansorne , Maurice Faure , Michel Languetin , Serge Zunino
发明人： Paule Bonnet , Remi Delansorne , Maurice Faure , Michel Languetin , Serge Zunino
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/52 , A61K31/522 , A61P11/14 , A61P37/08 , A61P43/00 , C07D20060101 , C07D211/46 , C07D235/30 , C07D295/08 , C07D401/12 , C07D403/12 , C07D409/04 , C07D473/08 , C07D247/02
CPC分类号： C07D235/30 , C07D401/12 , C07D409/04 , C07D473/08
摘要： ##STR1## The present invention concerns (4-substituted phenyl)4-oxy 1-aminobutane of the general formula (I) in which X is a nitrogen atom or >CH--CH, and R is a cyclic substituent chosen from the group comprising a) a xanthic substituent, b) a benzimidazolic substituent, as well as salts and optic isomers of the compounds of formula (I). The invention also concerns processes for obtaining the compounds of formula (I) and pharmaceutical compositions containing, as antihistamine ingredient, at least one compound of formula (I) or one of its salts with a mineral or organic acid.
摘要翻译： PCT No.PCT / FR91 / 00811 Sec。 371日期：1993年2月8日 102（e）日期1993年2月8日PCT 1991年10月17日PCT PCT。 第WO92 / 06977号公报 （I）本发明涉及其中X为氮原子或> CH-CH的通式（I）的（4-取代苯基）-4-氧-1-氨基丁烷，以及 R是选自以下的环状取代基：a）黄原酸取代基，b）苯并咪唑基取代基，以及式（I）化合物的盐和光学异构体。 本发明还涉及用于获得式（I）化合物和药物组合物的方法，所述药物组合物含有至少一种式（I）化合物或其盐与矿物或有机酸形成的抗组胺剂成分。
-
5.发明申请1-N-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them 失效1-N-苯基 - 氨基-1h-咪唑衍生物和含有它们的药物组合物公开(公告)号：US20070112009A1
公开(公告)日：2007-05-17
申请号：US10582778
申请日：2004-12-15
申请人： Jean Lafay , Benoit Rondot , Paule Bonnet , Thierry Clerc , Jaqueline Shields , Igor Duc , Eric Duranti , Francois Puccio , Christian Blot , Philippe Maillos
发明人： Jean Lafay , Benoit Rondot , Paule Bonnet , Thierry Clerc , Jaqueline Shields , Igor Duc , Eric Duranti , Francois Puccio , Christian Blot , Philippe Maillos
IPC分类号： A61K31/513 , A61K31/497 , A61K31/4152 , A61K31/501 , A61K31/4439 , C07D409/02 , C07D403/02
CPC分类号： C07D233/54 , C07D409/12 , C07D419/12
摘要： The invention relates to the compounds of formula (I): in which R1, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，R 4， / SUB，Q和Z如说明书中所定义。 本发明还涉及含有这些化合物的药物组合物。
-
6.发明授权Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents 有权吲唑，苯并异恶唑和苯并异噻唑及其作为雌激素剂的用途公开(公告)号：US07977364B2
公开(公告)日：2011-07-12
申请号：US11664887
申请日：2005-10-14
申请人： Benoit Rondot , Jean Lafay , Paule Bonnet , Thierry Clerc , Igor Duc , Eric Duranti , Francois Puccio , Jacqueline Shields , Christian Blot , Philippe Maillos
发明人： Benoit Rondot , Jean Lafay , Paule Bonnet , Thierry Clerc , Igor Duc , Eric Duranti , Francois Puccio , Jacqueline Shields , Christian Blot , Philippe Maillos
IPC分类号： A61K31/423 , A61K31/416 , C07D261/20 , C07D231/56
CPC分类号： C07D231/56 , C07D261/20 , C07D275/04 , C07D275/06 , C07D491/06
摘要： The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2，R3，X，Y和A如说明书中所定义。 这些化合物是雌激素受体的调节剂。
-
7.发明授权Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents 失效吲唑，苯并异恶唑和苯并异噻唑及其作为雌激素剂的用途公开(公告)号：US08173679B2
公开(公告)日：2012-05-08
申请号：US13152433
申请日：2011-06-03
申请人： Benoit Rondot , Jean Lafay , Paule Bonnet , Thierry Clerc , Igor Duc , Eric Duranti , Francois Puccio , Jacqueline Shields , Christian Blot , Philippe Maillos
发明人： Benoit Rondot , Jean Lafay , Paule Bonnet , Thierry Clerc , Igor Duc , Eric Duranti , Francois Puccio , Jacqueline Shields , Christian Blot , Philippe Maillos
IPC分类号： A61K31/454 , A61K31/428 , A61K31/423 , A61K31/416 , C07D261/20 , C07D401/06 , C07D275/04 , C07D413/12 , C07D231/56
CPC分类号： C07D231/56 , C07D261/20 , C07D275/04 , C07D275/06 , C07D491/06
摘要： The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2，R3，X，Y和A如说明书中所定义。 这些化合物是雌激素受体的调节剂。
-
8.发明授权公开(公告)号：US07476691B2
公开(公告)日：2009-01-13
申请号：US10555780
申请日：2003-05-16
申请人： Jean Lafay , Benoît Rondot , Denis Carniato , Paule Bonnet , Thierry Clerc , Jacqueline Shields , Igor Duc , Eric Duranti
发明人： Jean Lafay , Benoît Rondot , Denis Carniato , Paule Bonnet , Thierry Clerc , Jacqueline Shields , Igor Duc , Eric Duranti
IPC分类号： A61K31/381 , C07D333/64 , C07D333/66
CPC分类号： C07D333/54 , C07D333/76
摘要： The present invention relates to sulfamate benzothiophene compounds of the formula: (I) wherein R1, R2, R3, m and n are as defined in the specification. The invention also relates to pharmaceutical compositions containing these compounds and to methods of using them.
摘要翻译： 本发明涉及式（I）的氨基磺酸苯并噻吩化合物，其中R 1，R 2，R 3，m和n如说明书中所定义。 本发明还涉及含有这些化合物的药物组合物及其使用方法。
-
9.发明授权1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them 失效1-N-苯基氨基-1H-咪唑衍生物作为芳香酶抑制剂和含有它们的药物组合物公开(公告)号：US06737433B1
公开(公告)日：2004-05-18
申请号：US10319840
申请日：2002-12-16
申请人： Nathalie Adje , Paule Bonnet , Denis Carniato , Remi Delansorne , Jean Lafay , Jean-Claude Pascal
发明人： Nathalie Adje , Paule Bonnet , Denis Carniato , Remi Delansorne , Jean Lafay , Jean-Claude Pascal
IPC分类号： A61K314164
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Imidazole derivatives of the formula: in which R1 and R2 are each independently hydrogen, (C1-C6)alkyl or (C3-C8)cycloalkyl; n is 0, 1 or 2; R3, R4, R5 and R6 are each independently hydrogen or a (C1-C6)alkyl, halogen, cyano, (C1-C6)alkoxy, trifluoromethyl, (C1-C6)alkylthio, (C1-C6)alkylsulfonyl, sulfonamido, acyl, (C1-C6)alkoxycarbonyl, or carboxamido group; R3 and R6 together with the phenyl ring bearing them can also form a benzofurane, or a N-methylbenzotriazole. The invention also relates to pharmaceutical compositions containing these derivatives, and to the uses thereof.
摘要翻译： 下式的咪唑衍生物：其中R 1和R 2各自独立地为氢，（C 1 -C 6）烷基或（C 3 -C 8）环烷基; n为0,1或2; R 3，R 4，R 5和R 6各自独立地为氢或 （C1-C6）烷基，卤素，氰基，（C1-C6）烷氧基，三氟甲基，（C1-C6）烷硫基，（C1-C6）烷基磺酰基，亚磺酰氨基，酰基，（C1-C6）烷氧基羰基或甲酰氨基; R3 和R6与带有它们的苯环一起也可以形成苯并呋喃或N-甲基苯并三唑。 本发明还涉及含有这些衍生物的药物组合物及其用途。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.022 秒)
