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1.发明授权公开(公告)号：US08183015B2
公开(公告)日：2012-05-22
申请号：US12773581
申请日：2010-05-04
IPC分类号： C12P19/34
CPC分类号： C12N1/06 , C12N15/1003 , C12Q1/6806 , C12Q1/6848 , C12Q1/6851 , C12Q1/689 , C12Q2600/16 , C12Q2600/166 , C12Q2545/101
摘要： This invention relates to reagent comprising: any one of cells, viral particles, organelles, parasites, cells comprising organelles, cells comprising viral particles, cells comprising parasites, cells comprising bacterial cells and any combination thereof, the cells, viral particles, organelles or parasites comprising at least one nucleic acid sequence serving as an internal control (IC) target for nucleic acid testing (NAT) assay; wherein the reagent is suitable to be added to a test sample undergoing sample preparation to release, concentrate and/or purify nucleic acids and amplification and/or detection of nucleic acids so as to be used to verify: (i) the efficiency of sample preparation; and (ii) the efficiency of nucleic acid amplification and/or detection. The present invention also relates to a method to verify or validate the preparation and amplification and/or detection of a nucleic acid target sequence in a sample spiked with a reagent of the present invention.
摘要翻译： 本发明涉及试剂，其包含：细胞，病毒颗粒，细胞器，寄生虫，包含细胞器的细胞，包含病毒颗粒的细胞，包含寄生虫的细胞，包含细菌细胞的细胞及其任何组合，细胞，病毒颗粒，细胞器或寄生虫 包括用作核酸测试（NAT）测定的内部对照（IC）靶的至少一个核酸序列; 其中所述试剂适于加入经历样品制备的测试样品以释放，浓缩和/或纯化核酸，并扩增和/或检测核酸，以便用于验证：（i）样品制备的效率 ; 和（ii）核酸扩增和/或检测的效率。 本发明还涉及验证或验证掺有本发明试剂的样品中核酸靶序列的制备和扩增和/或检测的方法。
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2.发明申请公开(公告)号：US20100233720A1
公开(公告)日：2010-09-16
申请号：US12773581
申请日：2010-05-04
CPC分类号： C12N1/06 , C12N15/1003 , C12Q1/6806 , C12Q1/6848 , C12Q1/6851 , C12Q1/689 , C12Q2600/16 , C12Q2600/166 , C12Q2545/101
摘要： This invention relates to reagent comprising: any one of cells, viral particles, organelles, parasites, cells comprising organelles, cells comprising viral particles, cells comprising parasites, cells comprising bacterial cells and any combination thereof, the cells, viral particles, organelles or parasites comprising at least one nucleic acid sequence serving as an internal control (IC) target for nucleic acid testing (NAT) assay; wherein the reagent is suitable to be added to a test sample undergoing sample preparation to release, concentrate and/or purify nucleic acids and amplification and/or detection of nucleic acids so as to be used to verify: (i) the efficiency of sample preparation; and (ii) the efficiency of nucleic acid amplification and/or detection. The present invention also relates to a method to verify or validate the preparation and amplification and/or detection of a nucleic acid target sequence in a sample spiked with a reagent of the present invention.
摘要翻译： 本发明涉及试剂，其包含：细胞，病毒颗粒，细胞器，寄生虫，包含细胞器的细胞，包含病毒颗粒的细胞，包含寄生虫的细胞，包含细菌细胞的细胞及其任何组合，细胞，病毒颗粒，细胞器或寄生虫 包括用作核酸测试（NAT）测定的内部对照（IC）靶的至少一个核酸序列; 其中所述试剂适于加入经历样品制备的测试样品以释放，浓缩和/或纯化核酸，并扩增和/或检测核酸，以便用于验证：（i）样品制备的效率 ; 和（ii）核酸扩增和/或检测的效率。 本发明还涉及验证或验证掺有本发明试剂的样品中核酸靶序列的制备和扩增和/或检测的方法。
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3.发明授权公开(公告)号：US07718402B2
公开(公告)日：2010-05-18
申请号：US10538442
申请日：2003-12-15
IPC分类号： C12P19/34
CPC分类号： C12N1/06 , C12N15/1003 , C12Q1/6806 , C12Q1/6848 , C12Q1/6851 , C12Q1/689 , C12Q2600/16 , C12Q2600/166 , C12Q2545/101
摘要： This invention relates to reagent comprising: any one of cells, viral particles, organelles, parasites, cells comprising organelles, cells comprising viral particles, cells comprising parasites, cells comprising bacterial cells and any combination thereof, the cells, viral particles, organelles or parasites comprising at least one nucleic acid sequence serving as an internal control (IC) target for nucleic acid testing (NAT) assay; wherein the reagent is suitable to be added to a test sample undergoing sample preparation to release, concentrate and/or purify nucleic acids and amplification and/or detection of nucleic acids so as to be used to verify: (i) the efficiency of sample preparation; and (ii) the efficiency of nucleic acid amplification and/or detection. The present invention also relates to a method to verify or validate the preparation and amplification and/or detection of a nucleic acid target sequence in a sample spiked with a reagent of the present invention.
摘要翻译： 本发明涉及试剂，其包含：细胞，病毒颗粒，细胞器，寄生虫，包含细胞器的细胞，包含病毒颗粒的细胞，包含寄生虫的细胞，包含细菌细胞的细胞及其任何组合，细胞，病毒颗粒，细胞器或寄生虫 包括用作核酸测试（NAT）测定的内部对照（IC）靶的至少一个核酸序列; 其中所述试剂适于加入经历样品制备的测试样品以释放，浓缩和/或纯化核酸，并扩增和/或检测核酸，以便用于验证：（i）样品制备的效率 ; 和（ii）核酸扩增和/或检测的效率。 本发明还涉及验证或验证掺有本发明试剂的样品中核酸靶序列的制备和扩增和/或检测的方法。
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