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    Antibiotic aminoglycosides, processes of preparation and pharmaceutical compositions
    2.
    发明授权
    Antibiotic aminoglycosides, processes of preparation and pharmaceutical compositions 失效
    抗生素氨基糖苷类，制备方法和药物组合物

    公开(公告)号：US4031210A

    公开(公告)日：1977-06-21

    申请号：US630917

    申请日：1975-11-11

    申请人： Jean-Bernard Chazan ,  Jean-Claude Gasc

    发明人： Jean-Bernard Chazan ,  Jean-Claude Gasc

    IPC分类号： C07H15/12 ,  A61K31/7008 ,  B01J25/00 ,  B01J27/00 ,  C07B61/00 ,  C07H5/06 ,  C07H15/234 ,  C07H15/22 ,  A61K31/71

    CPC分类号： C07H15/234

    摘要： There are disclosed pharmaceutically-active aminoglycosides comprising 4-O-[2',6'-diamino 2',3',6'-tridesoxy .alpha.,D-ribohexopyranosyl] 6-O-[3"-methylamino 3",4",6"-tridesoxy .alpha.,D-xylohexopyranosyl] 2-desoxystreptamine of the formula: ##STR1## and the addition salts thereof with mineral acids or organic acids. Also disclosed are methods for preparation of the novel products as well as certain novel intermediate products. There are also disclosed pharmaceutical compositions in which the novel products are the active agents and a method for the treatment of bacteria infections in humans and animals.

    摘要翻译： 公开了含有4-O- [2'，6'-二氨基2'，3'，6'-三酰氧基α，D-核糖六吡喃糖基] 6-O- [3“ - 甲基氨基3”的药学活性氨基糖苷类， 4“，6” - 三酰氧基α，D-木糖六吡喃葡糖基] 2-脱氧神经胺，其分子式如下：其与无机酸或有机酸的加成盐。 还公开了制备新产品以及某些新型中间产物的方法。 还公开了其中新产品是活性剂的药物组合物和用于治疗人和动物细菌感染的方法。

    Benzylphenyl osides, method of preparation and use therefor
    4.
    发明授权
    Benzylphenyl osides, method of preparation and use therefor 失效
    苄基苯基膦，其制备方法及用途

    公开(公告)号：US4598068A

    公开(公告)日：1986-07-01

    申请号：US632009

    申请日：1984-07-18

    申请人： Soth Samreth ,  Francois Bellamy ,  Jean-Bernard Chazan

    发明人： Soth Samreth ,  Francois Bellamy ,  Jean-Bernard Chazan

    IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61P3/06 ,  C07H15/20 ,  C07H15/203

    CPC分类号： C07H15/203

    摘要： The present invention relates, by way of new industrial products, to the benzylphenyl osides of the formula ##STR1## in which: X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5, which are identical or different, each represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkyl group substituted by one or more halogen atoms (in particular a CF.sub.3 group), an OH group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 alkoxy group substituted by one or more halogen atoms, a nitro group, a group NR'R" (in which R' and R", which are identical or different, each represent the hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or an acetyl group), a methylthio group, a methylsulfinyl group or a mesyl group, andR represents an ose radical chosen from the group comprising(a) the .alpha.-L-rhamnosyl radical,(b) non-hydrolyzable monosaccharide radicals and(c) non-hydrolyzable monosaccharide radicals in which the hydroxyl group on the carbon atom in the 2-position is replaced with an amine group, the hydroxyl and amine groups of the group R being capable of acetylation, and their addition salts in cases where at least one of the groups X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5 and R comprises a basic radical.These new products are useful in therapy. They can be prepared by reducing the corresponding benzoylphenyl and .alpha.-hydroxybenzylphenyl osides.

    摘要翻译： 本发明通过新的工业产品涉及式（I）的苄基苯基酮，其中：相同或不同的X 1，X 2，X 3，X 4和X 5各自表示氢原子， 卤素原子，C1-C4烷基，被一个或多个卤素原子（特别是CF 3基团）取代的C 1 -C 4烷基，OH基，C 1 -C 4烷氧基，C 1 -C 4烷氧基取代 通过一个或多个卤素原子，硝基，NR'R“基团（其中R'和R”'相同或不同，各自表示氢原子，C 1 -C 4烷基或乙酰基 ），甲硫基，甲基亚磺酰基或甲磺酰基，R表示选自（a）α-L-鼠李糖基，（b）不可水解单糖基和（c） 2位上碳原子上的羟基被胺基取代的水解性单糖基团，其中羟基和胺基团 在基团X1，X2，X3，X4，X5和R中的至少一个包含碱性基团的情况下，p R能够进行乙酰化，以及它们的加成盐。 这些新产品在治疗中是有用的。 它们可以通过还原相应的苯甲酰基苯基和α-羟基苄基苯基膦来制备。