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15 条记录 (耗时 0.016 秒)

    Benzoyl-phenyl-piperidine derivatives
    2.
    发明授权
    Benzoyl-phenyl-piperidine derivatives 失效
    苯甲酰基 - 苯基 - 哌啶衍生物

    公开(公告)号：US4528294A

    公开(公告)日：1985-07-09

    申请号：US391915

    申请日：1982-06-24

    申请人： Bernard Majoie ,  Francois Bellamy ,  Pierre Dodey ,  Jacques Robin

    发明人： Bernard Majoie ,  Francois Bellamy ,  Pierre Dodey ,  Jacques Robin

    IPC分类号： C07D295/12 ,  A61K31/445 ,  A61K31/451 ,  A61P37/04 ,  C07D20060101 ,  C07D211/14 ,  C07D211/38 ,  C07D211/40 ,  C07D211/46 ,  C07D211/56 ,  C07D295/135

    CPC分类号： C07D295/135 ,  C07D211/14 ,  C07D211/46 ,  Y10S514/885

    摘要： The present invention relates to new benzoyl-phenyl-piperidine derivatives selected from the group consisting of:(i) 2-piperidinobenzophenones of the general formula: ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, which are identical or different, each represent an atom of hydrogen, a hydroxy group, CF.sub.3, a halogen, a lower alkyl group or a lower alkoxy group;R.sub.4 represents an atom of hydrogen, a halogen, an NO.sub.2 group, an NR'R" group [where R' and R", which are identical or different, represent an atom of hydrogen, a lower alkyl group or a CO.sub.2 R group (where R represents a lower alkyl group or a benzyl group)];R.sub.5 and R.sub.6, which are identical or different, each represent an atom of hydrogen, a C.sub.1 -C.sub.4 -alkyl group, an OH group, a phenyl group or a benzyl group; and(ii) acid addition salts thereof.The invention also relates to the method for preparing these new derivatives and to their use in therapeutics, particularly as immunostimulant and immunoadjuvant agents.

    摘要翻译： 本发明涉及选自以下的新的苯甲酰基 - 苯基 - 哌啶衍生物：（i）具有以下通式的2-哌啶二苯甲酮：其中：R1，R2和R3相同或不同 各自表示氢原子，羟基，CF 3，卤素，低级烷基或低级烷氧基; R 4表示氢原子，卤素，NO 2基，NR'R“基[其中R'和R”相同或不同，表示氢原子，低级烷基或CO 2 R基团 （其中R表示低级烷基或苄基）]; R5，R6相同或不同，分别表示氢原子，C1-C4烷基，OH基，苯基或苄基。 和（ii）其酸加成盐。 本发明还涉及制备这些新衍生物及其在治疗学中的用途的方法，特别是作为免疫刺激剂和免疫佐剂。

    Asymmetrical ester derivatives of 1,4-dihydrophyridine-3,5-dicarboxylic acid
    3.
    发明授权
    Asymmetrical ester derivatives of 1,4-dihydrophyridine-3,5-dicarboxylic acid 失效
    1,4-二氢吡啶-3,5-二羧酸的不对称酯衍生物

    公开(公告)号：US4806544A

    公开(公告)日：1989-02-21

    申请号：US27262

    申请日：1987-03-18

    申请人： Jacques Robin ,  Didier Pruneau ,  Francois Bellamy

    发明人： Jacques Robin ,  Didier Pruneau ,  Francois Bellamy

    IPC分类号： A61K31/435 ,  A61K31/438 ,  A61K31/4422 ,  A61P9/12 ,  C07D211/00 ,  C07D211/90 ,  C07D491/10 ,  C07D491/113 ,  A61K31/445 ,  C07D491/20

    CPC分类号： C07D491/10 ,  C07D211/00

    摘要： The present invention relates to novel asymmetrical esters derived from 1,4-dihydrophyridine-3,5-dicarboxylic acid, of the formula: ##STR1## in which: R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group, R.sub.2 represents a C.sub.1 -C.sub.4 alkyl group, a benzyl group, a benzoyl group or a phenyl group optionally substituted by one or more C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, cyano, nitro, hydroxyl or trifluoromethyl groups or by one or more halogen atoms, and R.sub.3 and R.sub.4, which are identical or different, each represent the hydrogen atom, a nitro group or a chlorine atom, their optical isomers and diastereoisomers and also the corresponding addition salts.These novel esters are useful in therapy, especially as antihypertensives.

    摘要翻译： 本发明涉及衍生自1,4-二氢吡啶-3,5-二羧酸的新型不对称酯，其具有下式：其中：R1表示C1-C4烷基，R2表示C1- C4烷基，苄基，苯甲酰基或任选被一个或多个C 1 -C 4烷氧基，C 1 -C 4烷基，氰基，硝基，羟基或三氟甲基取代或被一个或多个卤素原子取代的苯基， R 4相同或不同，各自表示氢原子，硝基或氯原子，它们的光学异构体和非对映异构体以及相应的加成盐。 这些新型酯可用于治疗，特别是抗高血压药。

    PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS
    5.
    发明申请
    PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS 有权
    合成2-氨基噻唑化合物作为激酶抑制剂的方法

    公开(公告)号：US20100121063A1

    公开(公告)日：2010-05-13

    申请号：US12526827

    申请日：2008-02-13

    申请人： Alain Moussy ,  Philippe Reginault ,  Francois Bellamy ,  Anne Lermet

    发明人： Alain Moussy ,  Philippe Reginault ,  Francois Bellamy ,  Anne Lermet

    IPC分类号： C07D417/14

    CPC分类号： C07D417/04

    摘要： The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (1) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.

    摘要翻译： 本发明涉及一种制备具有式（1）的药物化合物的工业方法，其可用作某些酪氨酸激酶抑制剂，更特别地涉及c-kit和bcr-abl抑制剂。 R1和R2相同或不同，各自表示氢，卤素原子，烷基，烷氧基，三氟甲基，氨基，烷基氨基，二烷基氨基，增溶基团; m为0-5，n为0-4; 基团R 3表示如权利要求书中所述的芳基或杂芳基。