公开(公告)号：US20050065114A1

公开(公告)日：2005-03-24

申请号：US10668665

申请日：2003-09-23

申请人： Jean-Claude Yvin ,  Frank Jamois ,  Vaclav Vetvicka

发明人： Jean-Claude Yvin ,  Frank Jamois ,  Vaclav Vetvicka

IPC分类号： A61K31/702 ,  A61K31/716 ,  A61K45/06 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61K31/715

CPC分类号： A61K31/716 ,  A61K31/702 ,  A61K2300/00

摘要： A therapeutical method comprising administration of a composition comprising an amount of oligo-β-(1,3)-glucan and a pharmaceutically acceptable carrier, to a human being or to a warm-blood animal suffering from a disease selected from the group consisting in a tumor, a cancer, a viral disease, a bacterial disease, a fungal disease, a disease of the immune system, an auto-immune disease or a disease related to a deficiency of immunostimulation, wherein the amount of oligo-β-(1,3)-glucan is effective to treat the disease.

摘要翻译： 一种治疗方法，其包括将包含一定量的寡聚β-（1,3） - 葡聚糖和药学上可接受的载体的组合物施用于患有选自以下的疾病的人或温血动物： 肿瘤，癌症，病毒性疾病，细菌性疾病，真菌性疾病，免疫系统疾病，自身免疫疾病或与免疫刺激缺陷有关的疾病，其中寡聚β-（1 ，3） - 葡聚糖有效治疗疾病。

公开(公告)号：US08367641B2

公开(公告)日：2013-02-05

申请号：US12520612

申请日：2007-12-20

申请人： Jean-Claude Yvin ,  Karine Descroix ,  Vincent Ferrieres ,  Frank Jamois ,  Isabelle Laurent ,  Vaclav Vetvika

发明人： Jean-Claude Yvin ,  Karine Descroix ,  Vincent Ferrieres ,  Frank Jamois ,  Isabelle Laurent ,  Vaclav Vetvika

IPC分类号： A61K31/702 ,  A61K31/716 ,  C07H3/06

CPC分类号： C07H3/06 ,  A61K31/702 ,  C07H3/08 ,  Y02P20/55

摘要： The present invention relates to the use of at least one compound of formula (I) or (II), in which R1 is H and n is an integer from 2 to 10, for the preparation of a medicament for treating diseases chosen from the group comprising tumour, cancer, viral disease, bacterial disease, fungal disease, disease of the immune system, auto-immune disease or disease linked to a deficiency in immunostimulation, in human beings and warm-blooded animals. The invention also relates to new products having a mannose or mannitol termination as well as a method for preparing them.

摘要翻译： 本发明涉及至少一种式（I）或（II）化合物，其中R 1为H且n为2至10的整数，用于制备用于治疗疾病的药物的用途 包括肿瘤，癌症，病毒性疾病，细菌性疾病，真菌病，免疫系统疾病，自身免疫疾病或与免疫刺激缺陷有关的疾病，人类和温血动物。 本发明还涉及具有甘露糖或甘露醇终止物的新产品及其制备方法。

公开(公告)号：US20100286388A1

公开(公告)日：2010-11-11

申请号：US12520612

申请日：2007-12-20

申请人： Jean-Claude Yvin ,  Karine Descroix ,  Vincent Ferrieres ,  Frank Jamois ,  Isabelle Laurent ,  Vaclav Vetvika

发明人： Jean-Claude Yvin ,  Karine Descroix ,  Vincent Ferrieres ,  Frank Jamois ,  Isabelle Laurent ,  Vaclav Vetvika

IPC分类号： C08B37/00 ,  C07H1/00 ,  C07H3/06

CPC分类号： C07H3/06 ,  A61K31/702 ,  C07H3/08 ,  Y02P20/55

摘要： The present invention relates to the use of at least one compound of formula (I) or (II), in which R1 is H and n is an integer from 2 to 10, for the preparation of a medicament for treating diseases chosen from the group comprising tumour, cancer, viral disease, bacterial disease, fungal disease, disease of the immune system, auto-immune disease or disease linked to a deficiency in immunostimulation, in human beings and warm-blooded animals. The invention also relates to new products having a mannose or mannitol termination as well as a method for preparing them.

摘要翻译： 本发明涉及至少一种式（I）或（II）化合物，其中R 1为H且n为2至10的整数，用于制备用于治疗疾病的药物的用途 包括肿瘤，癌症，病毒性疾病，细菌性疾病，真菌性疾病，免疫系统疾病，自身免疫疾病或与免疫刺激缺陷有关的疾病，人类和温血动物。 本发明还涉及具有甘露糖或甘露醇终止物的新产品及其制备方法。

公开(公告)号：US06951934B2

公开(公告)日：2005-10-04

申请号：US10182976

申请日：2001-02-02

申请人： Jean-Claude Yvin ,  Frank Jamois ,  Vincent Ferrieres ,  Daniel Plusquellec

发明人： Jean-Claude Yvin ,  Frank Jamois ,  Vincent Ferrieres ,  Daniel Plusquellec

IPC分类号： A61K8/60 ,  A61K8/73 ,  A61K31/7028 ,  A61P43/00 ,  C07H5/10 ,  C07H13/02 ,  C07H15/04 ,  C07H15/18 ,  C07H1/00 ,  C07H15/00 ,  C07H17/00 ,  C07H17/02

CPC分类号： C07H5/10 ,  C07H13/02 ,  C07H15/04

摘要： The present invention relates to a novel method of chemically preparing functionalized derivatives of β-(1,3)-glucans, enabling obtaining oligosaccharides which are free or which comprise specific groups such as, for example, sulphate, phosphate, methyl, in pre-defined positions. This method includes a reaction between a glycosyl donor of formula (Ia) or (Ib) and a glycosyl acceptor of formula (II), defined in the claims. Application: Preparation of biologically active compounds which can be used in the agricultural, cosmetic or pharmaceutical fields.

摘要翻译： 本发明涉及一种化学制备β-（1,3） - 葡聚糖官能化衍生物的新方法，能够获得游离的或包含特定基团的寡糖，例如硫酸盐，磷酸盐，甲基， 定义的位置。 该方法包括权利要求中定义的式（Ia）或（Ib）的糖供体与式（II）的糖基受体之间的反应。 应用：可用于农业，化妆品或制药领域的生物活性化合物的制备。

公开(公告)号：US06632940B1

公开(公告)日：2003-10-14

申请号：US09673295

申请日：2000-10-13

申请人： Jean-Claude Yvin ,  Frank Jamois ,  Vincent Ferrieres ,  Daniel Plusquellec

发明人： Jean-Claude Yvin ,  Frank Jamois ,  Vincent Ferrieres ,  Daniel Plusquellec

IPC分类号： C13K500

CPC分类号： C07H3/06

摘要： The invention concerns a method for preparing Laminaribiose comprising a step for glycoside binding between a donor and an acceptor of glycosyl. The invention is characterized in that the glycosyl donor is in pyranose form and corresponds to formula (II); the glycosyl acceptor is in furanose form and corresponds to formula (III); said binding step is performed in solution in an anhydrous organic solvent, at a temperature ranging between −80° C. and 40° C., for a time interval ranging between 1 minute and 8 hours, in the presence of a suitable promoter.

摘要翻译： 本发明涉及一种制备层叠二糖的方法，包括供体和糖基受体之间糖苷结合的步骤。 本发明的特征在于糖基供体是吡喃糖形式，对应于式（II）; 糖基受体是呋喃糖形式，对应于式（III）; 所述结合步骤在无水有机溶剂的溶液中，在-80℃至40℃的温度范围内，在合适的助催化剂存在下，时间间隔为1分钟至8小时。 / PTEXT>

公开(公告)号：US20130267479A1

公开(公告)日：2013-10-10

申请号：US13993191

申请日：2011-12-09

申请人： Frank Jamois

发明人： Frank Jamois

IPC分类号： C05C11/00

CPC分类号： C05C11/00 ,  A01N55/08 ,  C01B35/08 ,  C07F5/04

摘要： The present invention relates to solutions including at least one boron complex obtained through the reaction between at least one boron salt, consisting of a borate anion selected from within the group consisting of metaborate anions, tetraborate anions, pentaborate anions, octaborate anions, decaborate anions, and the mixtures thereof, and a cation selected from within the group including sodium cations, potassium cations, ammonium cations, and the mixtures thereof, and at least one polyol and at least one amino compound. The basic boron concentration is greater than 2 wt % of the total weight of the solution. The invention also relates to a method for preparing said solutions and to the uses of said solutions, particularly in the field of agriculture.

摘要翻译： 本发明涉及包含至少一种硼化合物的溶液，所述硼配合物通过至少一种硼盐之间的反应获得，所述硼盐由选自偏硼酸盐阴离子，四硼酸根阴离子，五硼酸盐阴离子，八硼酸盐阴离子，十硼酸盐阴离子， 和其混合物，以及选自钠阳离子，钾阳离子，铵阳离子及其混合物，以及至少一种多元醇和至少一种氨基化合物的阳离子。 基本的硼浓度大于溶液总重量的2重量％。 本发明还涉及一种制备所述溶液的方法以及所述溶液的用途，特别是在农业领域。