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公开(公告)号：US08338597B2
公开(公告)日：2012-12-25
申请号：US13325089
申请日：2011-12-14
申请人： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
发明人： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
IPC分类号： C07D239/02 , A61K31/515
CPC分类号： C07D401/14 , C07D213/22 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention and intermediate compounds useful in these processes.
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公开(公告)号：US08101770B2
公开(公告)日：2012-01-24
申请号：US11304057
申请日：2005-12-15
申请人： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
发明人： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
IPC分类号： C07D401/00 , A61K31/44
CPC分类号： C07D401/14 , C07D213/22 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention and intermediate compounds useful in these processes.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法和用于这些方法的中间体化合物。
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公开(公告)号：US20120190699A1
公开(公告)日：2012-07-26
申请号：US13325089
申请日：2011-12-14
申请人： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
发明人： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
IPC分类号： A61K31/506 , A61K31/444 , C12N9/99 , C07D401/14 , C07D213/82 , A61K31/44 , A61P37/06 , A61P29/00 , A61P11/06 , A61P11/00 , A61P19/02 , A61P17/06 , A61P17/00 , A61P17/14 , A61P1/00 , A61P1/18 , A61P1/04 , A61P37/08 , A61P9/10 , A61P31/18 , A61P3/10 , C07D401/04
CPC分类号： C07D401/14 , C07D213/22 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention and intermediate compounds useful in these processes.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法和用于这些方法的中间体化合物。
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公开(公告)号：US20060183911A1
公开(公告)日：2006-08-17
申请号：US11304057
申请日：2005-12-15
申请人： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
发明人： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
IPC分类号： A61K31/44 , C07D401/00
CPC分类号： C07D401/14 , C07D213/22 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention and intermediate compounds useful in these processes.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法和用于这些方法的中间体化合物。
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公开(公告)号：US07786120B2
公开(公告)日：2010-08-31
申请号：US11510126
申请日：2006-08-25
申请人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Julian M. C. Golec , Michael Mortimore
发明人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Julian M. C. Golec , Michael Mortimore
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/04 , C07D213/64 , C07D213/74 , C07D401/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US20070185125A1
公开(公告)日：2007-08-09
申请号：US11510126
申请日：2006-08-25
申请人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Julian Golec , Michael Mortimore
发明人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Julian Golec , Michael Mortimore
IPC分类号： A61K31/497 , A61K31/496 , A61K31/4745 , A61K31/506 , A61K31/444 , C07D403/14 , C07D401/02
CPC分类号： C07D401/04 , C07D213/64 , C07D213/74 , C07D401/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供制备本发明化合物的方法。
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公开(公告)号：US07786130B2
公开(公告)日：2010-08-31
申请号：US11511086
申请日：2006-08-28
申请人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
发明人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
IPC分类号： C07D401/04 , A61K31/44
CPC分类号： C07D213/64 , C07D401/14 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US20070179156A1
公开(公告)日：2007-08-02
申请号：US11511086
申请日：2006-08-28
申请人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
发明人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
IPC分类号： A61K31/497 , A61K31/4709 , A61K31/444 , C07D401/14 , C07D403/14
CPC分类号： C07D213/64 , C07D401/14 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US20100105914A1
公开(公告)日：2010-04-29
申请号：US12630350
申请日：2009-12-03
申请人： Jean-Damien Charrier , Steven Durrant , Michael Mortimore , Michael O'Donnell , Alistair Rutherford , Sharn Ramaya , John R. Studley , Martin Trudeau , Adam Looker
发明人： Jean-Damien Charrier , Steven Durrant , Michael Mortimore , Michael O'Donnell , Alistair Rutherford , Sharn Ramaya , John R. Studley , Martin Trudeau , Adam Looker
IPC分类号： C07D405/14 , C07D417/14 , C07D405/12
CPC分类号： C07D405/12 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/12 , C07K5/0202 , Y02A50/385 , Y02A50/387 , Y02A50/389
摘要： The present invention provides a compound of formula I: wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula I, and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.
摘要翻译： 本发明提供式I化合物：其中变量如本文所定义。 本发明还提供制备式I化合物的方法及其中间体，包含这些化合物的药物组合物，以及使用该化合物和组合物的方法。
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公开(公告)号：US20050233979A1
公开(公告)日：2005-10-20
申请号：US11069895
申请日：2005-02-28
申请人： Jean-Damien Charrier , Steven Durrant , Michael Mortimore , Michael O'Donnell , Alistair Rutherford , Sharn Ramaya , John Studley , Martin Trudeau , Adam Looker
发明人： Jean-Damien Charrier , Steven Durrant , Michael Mortimore , Michael O'Donnell , Alistair Rutherford , Sharn Ramaya , John Studley , Martin Trudeau , Adam Looker
IPC分类号： A61K38/04 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/04 , C07D45/14
CPC分类号： C07D405/12 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/12 , C07K5/0202 , Y02A50/385 , Y02A50/387 , Y02A50/389
摘要： The present invention provides a compound of formula wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula I, and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.
摘要翻译： 本发明提供了式的化合物，其中变量如本文所定义。 本发明还提供制备式I化合物的方法及其中间体，包含这些化合物的药物组合物，以及使用该化合物和组合物的方法。
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