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公开(公告)号：US6004925A
公开(公告)日：1999-12-21
申请号：US940095
申请日：1997-09-29
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz , Jean Dufourcq
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz , Jean Dufourcq
IPC分类号： C12N15/09 , A61K9/19 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/17 , A61K47/48 , A61P3/04 , A61P3/06 , A61P9/02 , A61P9/10 , C07K7/00 , C07K7/08 , C07K14/00 , C07K14/725 , C07K14/775 , C12N5/10 , C12P21/02
CPC分类号： C07K14/775 , A61K38/1709 , C07K7/08
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
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2.发明申请Gene Therapy Approaches to Supply Apolipoprotein A-I Agonists and Their Use to Treat Dyslipidemic Disorder 审中-公开提供载脂蛋白A-I激动剂的基因治疗方法及其用于治疗血脂紊乱公开(公告)号：US20080050351A1
公开(公告)日：2008-02-28
申请号：US11764522
申请日：2007-06-18
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz , Jean Dufourcq
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz , Jean Dufourcq
IPC分类号： A61K48/00 , A61K35/00 , A61P3/00 , A61P9/00 , C07H21/00 , C07K14/435 , C07K7/08 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
CPC分类号： A61K48/005 , A61K38/00 , A61K48/00 , A61K51/08 , C07K14/775
摘要： The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, reproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock.
摘要翻译： 本发明涉及提供编码载脂蛋白A-I（ApoA-I）的天然形式的修饰形式的核苷酸序列的遗传方法：成熟ApoA-I，reproApoA-I和proApoA-I; 包括修饰为含有ApoA-1激动剂的天然ApoA-I，其模拟ApoA-I的活性的肽; ApoA-I超级拮抗剂，超过天然ApoA-I活性的肽; 和具有由一个或多个ApoA-1激动剂的核苷酸序列替代的一个或多个两亲性螺旋的修饰的天然ApoA-I; 用于治疗与脂蛋白血症相关的疾病，包括心血管疾病，动脉粥样硬化，再狭窄，高脂血症和其它疾病如败血性休克。
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公开(公告)号：US20050148513A1
公开(公告)日：2005-07-07
申请号：US10991217
申请日：2004-11-16
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz , Jean Dufourcq
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz , Jean Dufourcq
IPC分类号： C12N15/09 , A61K38/00 , A61K38/16 , A61K48/00 , A61P3/00 , A61P3/06 , A61P9/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07H21/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/47 , C07K14/775 , C12N5/10 , A61K38/17 , A61K38/10 , C07H21/04
CPC分类号： A61K48/005 , A61K38/00 , A61K48/00 , A61K51/08 , C07K14/775
摘要： The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock.
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公开(公告)号：US20050215467A1
公开(公告)日：2005-09-29
申请号：US10715895
申请日：2003-11-17
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz , Jean Dufourcq
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz , Jean Dufourcq
IPC分类号： C12N15/09 , A61K9/19 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/17 , A61K47/48 , A61P3/04 , A61P3/06 , A61P9/02 , A61P9/10 , C07K7/00 , C07K7/08 , C07K14/00 , C07K14/725 , C07K14/775 , C12N5/10 , C12P21/02
CPC分类号： C07K14/775 , A61K38/1709 , C07K7/08
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译： 本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。 肽和肽类似物可用于治疗与血脂异常相关的各种障碍。
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公开(公告)号：US6046166A
公开(公告)日：2000-04-04
申请号：US940096
申请日：1997-09-29
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61K48/00 , A61P3/06 , A61P9/00 , A61P9/10 , C07K14/00 , C07K14/775
CPC分类号： A61K38/1709 , C07K14/001 , C07K14/775 , C07K7/08 , A61K48/00
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
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6.发明申请Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders 失效载脂蛋白A-1激动剂及其用于治疗血脂异常的疾病公开(公告)号：US20050203284A9
公开(公告)日：2005-09-15
申请号：US10099574
申请日：2002-03-15
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61K48/00 , A61P3/06 , A61P9/00 , A61P9/10 , C07K14/00 , C07K14/775
CPC分类号： A61K38/1709 , A61K48/00 , C07K7/08 , C07K14/001 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译： 本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。 肽和肽类似物可用于治疗与血脂异常相关的各种障碍。
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7.发明申请Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders 审中-公开载脂蛋白A-1激动剂及其用于治疗血脂异常的疾病公开(公告)号：US20080058270A1
公开(公告)日：2008-03-06
申请号：US11704871
申请日：2007-02-09
CPC分类号： A61K38/10 , A61K38/16 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译： 本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。 肽和肽类似物可用于治疗与血脂异常相关的各种障碍。
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公开(公告)号：US20050080013A1
公开(公告)日：2005-04-14
申请号：US10937767
申请日：2004-09-08
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61K48/00 , A61P3/06 , A61P9/00 , A61P9/10 , C07K14/00 , C07K14/775 , C07K7/08
CPC分类号： A61K38/1709 , A61K48/00 , C07K7/08 , C07K14/001 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
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公开(公告)号：US6037323A
公开(公告)日：2000-03-14
申请号：US940093
申请日：1997-09-29
IPC分类号： A61K9/08 , A61K9/127 , A61K9/19 , A61K38/00 , A61K38/02 , A61K38/08 , A61K38/10 , A61K38/16 , A61K47/24 , A61K47/44 , A61K47/48 , A61P3/00 , A61P3/06 , A61P9/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07K14/47 , C07K14/775 , C07K7/08
CPC分类号： A61K38/10 , A61K38/16 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
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公开(公告)号：US07211565B2
公开(公告)日：2007-05-01
申请号：US10801897
申请日：2004-03-15
IPC分类号： A61K38/10 , A61K38/16 , C07K7/08 , C07K14/775
CPC分类号： A61K38/10 , A61K38/16 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
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