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    NOVEL FLUORESCENT DERIVATIVES OF POLYAMINES, METHOD FOR PREPARING SAME AND APPLICATIONS THEREOF AS DIAGNOSIS TOOLS IN THE TREATMENT OF CANCEROUS TUMORS
    1.
    发明申请
    NOVEL FLUORESCENT DERIVATIVES OF POLYAMINES, METHOD FOR PREPARING SAME AND APPLICATIONS THEREOF AS DIAGNOSIS TOOLS IN THE TREATMENT OF CANCEROUS TUMORS 审中-公开
    聚氨酯的新型荧光衍生物，其制备方法及其在治疗癌症肿瘤中的诊断工具的应用

    公开(公告)号：US20100202975A1

    公开(公告)日：2010-08-12

    申请号：US12670611

    申请日：2008-07-28

    申请人： Jean-Philippe Annereau ,  Jean-Marc Barret ,  Yves Guminski ,  Thierry Imbert

    发明人： Jean-Philippe Annereau ,  Jean-Marc Barret ,  Yves Guminski ,  Thierry Imbert

    IPC分类号： A61K49/00 ,  C07D271/12

    CPC分类号： C07D271/12

    摘要： The invention relates to novel fluorescent derivatives of polyamines having a benzoxadiazole group, to a method for preparing the same and to the use thereof as diagnosis tools for emphasising the polyamine transport system in cancerous cells in order to adapt the treatment thereof, and thus for selecting patients carrying such tumours in order to adapt their treatment. The derivatives are of the formula (I) or a pharmaceutically acceptable salt thereof, in which: R1 is one or more NO2 groups in position 4 or 6, or a SO2Ph, SO2NMe2, SO2NH2 or SO3H group; R2 is hydrogen, C1-6 alkyl, benzyl, a perfluoroalkyl group; the values of a, b, c range from 2 to 5 independently from each other and represent alkylene chains separating the amino groups, and the values of d and e can independently be 0 or 1.

    摘要翻译： 本发明涉及具有苯并恶二唑基团的多胺的新型荧光衍生物，其制备方法及其作为诊断工具，用于强调癌细胞中的多胺转运体系以适应其治疗，从而用于选择 携带这种肿瘤的患者为了适应其治疗。 衍生物具有式（I）化合物或其药学上可接受的盐，其中：R1是位置4或6中的一个或多个NO 2基团，或SO 2 Ph，SO 2 NMe 2，SO 2 NH 2或SO 3 H基团; R2是氢，C1-6烷基，苄基，全氟烷基; a，b，c的值彼此独立地为2至5，并且表示分隔氨基的亚烷基链，d和e的值可以独立地为0或1。

    Fluorescent derivatives of polyamines, method for preparing same and applications thereof as diagnosis tools in the treatment of cancerous tumors
    2.
    发明授权
    Fluorescent derivatives of polyamines, method for preparing same and applications thereof as diagnosis tools in the treatment of cancerous tumors 有权
    多胺的荧光衍生物，其制备方法及其在治疗癌性肿瘤中的诊断工具的应用

    公开(公告)号：US08569011B2

    公开(公告)日：2013-10-29

    申请号：US13493556

    申请日：2012-06-11

    申请人： Jean-Philippe Annereau ,  Jean-Marc Barret ,  Yves Guminski ,  Thierry Imbert

    发明人： Jean-Philippe Annereau ,  Jean-Marc Barret ,  Yves Guminski ,  Thierry Imbert

    IPC分类号： G01N21/64

    CPC分类号： C07D271/12

    摘要： The invention relates to novel fluorescent derivatives of polyamines having a benzoxadiazole group, to a method for preparing the same and to the use thereof as diagnosis tools for emphasising the polyamine transport system in cancerous cells in order to adapt the treatment thereof, and thus for selecting patients carrying such tumors in order to adapt their treatment. The derivatives are of the formula (I) or a pharmaceutically acceptable salt thereof, in which: R1 is one or more NO2 groups in position 4 or 6, or a SO2Ph, SO2NMe2, SO2NH2 or SO3H group; R2 is hydrogen, C1-6 alkyl, benzyl, a perfluoroalkyl group; the values of a, b, c range from 2 to 5 independently from each other and represent alkylene chains separating the amino groups, and the values of d and e can independently be 0 or 1.

    摘要翻译： 本发明涉及具有苯并恶二唑基团的多胺的新型荧光衍生物，其制备方法及其作为诊断工具，用于强调癌细胞中的多胺转运体系以适应其治疗，从而用于选择 携带这种肿瘤的患者为了适应其治疗。 衍生物具有式（I）化合物或其药学上可接受的盐，其中：R1是位置4或6中的一个或多个NO 2基团，或SO 2 Ph，SO 2 NMe 2，SO 2 NH 2或SO 3 H基团; R2是氢，C1-6烷基，苄基，全氟烷基; a，b，c的值彼此独立地为2至5，并且表示分隔氨基的亚烷基链，d和e的值可以独立地为0或1。

    FLUORESCENT DERIVATIVES OF POLYAMINES, METHOD FOR PREPARING SAME AND APPLICATIONS THEREOF AS DIAGNOSIS TOOLS IN THE TREATMENT OF CANCEROUS TUMORS
    3.
    发明申请
    FLUORESCENT DERIVATIVES OF POLYAMINES, METHOD FOR PREPARING SAME AND APPLICATIONS THEREOF AS DIAGNOSIS TOOLS IN THE TREATMENT OF CANCEROUS TUMORS 有权
    聚氨酯的荧光衍生物，其制备方法及其应用于诊断癌症肿瘤中的诊断工具

    公开(公告)号：US20120252059A1

    公开(公告)日：2012-10-04

    申请号：US13493556

    申请日：2012-06-11

    申请人： Jean-Philippe Annereau ,  Jean-Marc Barret ,  Yves Guminski ,  Thierry Imbert

    发明人： Jean-Philippe Annereau ,  Jean-Marc Barret ,  Yves Guminski ,  Thierry Imbert

    IPC分类号： G01N21/64

    CPC分类号： C07D271/12

    摘要： The invention relates to novel fluorescent derivatives of polyamines having a benzoxadiazole group, to a method for preparing the same and to the use thereof as diagnosis tools for emphasising the polyamine transport system in cancerous cells in order to adapt the treatment thereof, and thus for selecting patients carrying such tumours in order to adapt their treatment. The derivatives are of the formula (I) or a pharmaceutically acceptable salt thereof, in which: R1 is one or more NO2 groups in position 4 or 6, or a SO2Ph, SO2NMe2, SO2NH2 or SO3H group; R2 is hydrogen, C1-6 alkyl, benzyl, a perfluoroalkyl group; the values of a, b, c range from 2 to 5 independently from each other and represent alkylene chains separating the amino groups, and the values of d and e can independently be 0 or 1.

    摘要翻译： 本发明涉及具有苯并恶二唑基团的多胺的新型荧光衍生物，其制备方法及其作为诊断工具，用于强调癌细胞中的多胺转运体系以适应其治疗，从而用于选择 携带这种肿瘤的患者为了适应其治疗。 衍生物具有式（I）化合物或其药学上可接受的盐，其中：R1是位置4或6中的一个或多个NO 2基团，或SO 2 Ph，SO 2 NMe 2，SO 2 NH 2或SO 3 H基团; R2是氢，C1-6烷基，苄基，全氟烷基; a，b，c的值彼此独立地为2至5，并且表示分隔氨基的亚烷基链，d和e的值可以独立地为0或1。