-
公开(公告)号：US20090142316A1
公开(公告)日：2009-06-04
申请号：US11658858
申请日：2005-07-29
申请人： Jean-Pierre Majoral , Anne-Marie Jeannine Jacqueline Caminade , Jean-Jacques Fournie , Laurent Griffe , Mary Poupot-Marsan , Remy Poupot , Cedric-Olivier Turrin
发明人： Jean-Pierre Majoral , Anne-Marie Jeannine Jacqueline Caminade , Jean-Jacques Fournie , Laurent Griffe , Mary Poupot-Marsan , Remy Poupot , Cedric-Olivier Turrin
CPC分类号： A61K31/663 , A61K31/662 , A61K31/675 , A61K31/80 , A61K35/26 , C07F9/65815 , C07F9/65817 , C12N5/0646 , C12N2501/23 , C12N2501/999 , A61K2300/00
摘要： The present invention relates to the use of dendrimers with monophosphonic or bisphosphonic terminations in order to stimulate the growth of cell cultures or to activate cells in culture.
摘要翻译： 本发明涉及具有单膦酸或双膦酸末端的树枝状大分子的用途，以刺激细胞培养物的生长或激活培养物中的细胞。
-
公开(公告)号：US08815834B2
公开(公告)日：2014-08-26
申请号：US11658858
申请日：2005-07-29
申请人： Jean-Pierre Majoral , Anne-Marie Jeannine Jacqueline Caminade , Jean-Jacques Fournie , Laurent Griffe , Mary Poupot-Marsan , Rémy Poupot , Cédric-Olivier Turrin
发明人： Jean-Pierre Majoral , Anne-Marie Jeannine Jacqueline Caminade , Jean-Jacques Fournie , Laurent Griffe , Mary Poupot-Marsan , Rémy Poupot , Cédric-Olivier Turrin
IPC分类号： A61K31/66 , A61K31/663 , A61K31/675
CPC分类号： A61K31/663 , A61K31/662 , A61K31/675 , A61K31/80 , A61K35/26 , C07F9/65815 , C07F9/65817 , C12N5/0646 , C12N2501/23 , C12N2501/999 , A61K2300/00
摘要： The present invention relates to the use of dendrimers with monophosphonic or bisphosphonic terminations in order to stimulate the growth of cell cultures or to activate cells in culture.
摘要翻译： 本发明涉及具有单膦酸或双膦酸末端的树枝状大分子的用途，以刺激细胞培养物的生长或激活培养物中的细胞。
-
公开(公告)号：US20100173871A1
公开(公告)日：2010-07-08
申请号：US12525416
申请日：2008-08-01
申请人： Mary Poupot , Remy Poupot , Jean-Jacques Fournie , Damien Portevin , Severine Fruchon , Jean-Luc Davignon , Cedric-Olivier Davignon , Anne-Marie Caminade , Jean-Pierre Majoral , Oliver Rolland
发明人： Mary Poupot , Remy Poupot , Jean-Jacques Fournie , Damien Portevin , Severine Fruchon , Jean-Luc Davignon , Cedric-Olivier Davignon , Anne-Marie Caminade , Jean-Pierre Majoral , Oliver Rolland
IPC分类号： A61K31/66 , A61K31/695 , A61K31/675 , A61K31/6615
CPC分类号： A61K31/80 , C07C211/14 , C07C237/10 , C07F9/26 , C07F9/3817 , C07F9/4009 , C07F9/65815 , C07F9/65817
摘要： A method for treating inflammatory diseases through an anti-inflammatory type activation of monocytes, the method includes the administration to a patient in need thereof of an effective quantity of at least one dendrimer with mono- or biphosphonic terminations.
摘要翻译： 通过单核细胞的抗炎型激活治疗炎性疾病的方法，所述方法包括向有需要的患者施用有效量的至少一种具有单或双膦末端的树枝状大分子。
-
公开(公告)号：US06624151B1
公开(公告)日：2003-09-23
申请号：US09958323
申请日：2001-12-20
申请人： Christian Belmant , Marc Bonneville , Marc Alix Peyrat , Jean-Jacques Fournie , Alan P. Kozikowski
发明人： Christian Belmant , Marc Bonneville , Marc Alix Peyrat , Jean-Jacques Fournie , Alan P. Kozikowski
IPC分类号： A61K3166
CPC分类号： C12N5/0636 , A61K2035/122 , C07F9/4028 , C07F9/4037 , C07F9/4075 , C07F9/65505 , C12N2501/999
摘要： The invention concerns compounds CH3—R1—(CH1)2—R2 wherein: R1 is selected among a tertiary alcohol; a 1,2-diol; a halohydrine; an apoxide; an alkene; an aldehyde or an &agr;-hydroxyaldehyde; and R2 is selected among a methylenediphosphonate; a difluoromethylenediphosphonate; or a monofluoromethylenediphosphoneate. The invention also concerns the uses of said compounds as selective inhibitors of T&ggr;9&dgr;2 lymphocytes, and their uses, in particular for therapeutic purposes.
摘要翻译： 本发明涉及化合物CH3-R1（CH1）2-R2，其中：R1选自叔醇; 1,2-二醇; 卤代水 过氧化物 烯烃 醛或α-羟基醛; 并且R2选自亚甲基二膦酸盐; 二氟亚甲基二膦酸盐; 或单氟亚甲基二膦酸酯。 本发明还涉及所述化合物作为Tgamma9delta2淋巴细胞的选择性抑制剂及其用途，特别是用于治疗目的的用途。
-
公开(公告)号：US07625879B2
公开(公告)日：2009-12-01
申请号：US11512688
申请日：2006-08-30
IPC分类号： A61K31/66 , A01N57/00 , G01N33/00 , C12N5/06 , C12N5/16 , A01N65/00 , C07D301/36 , C07D303/02 , C07C321/00 , C07C323/00 , C07C381/00
CPC分类号： C07H19/10 , A61K31/66 , A61K39/00 , A61K45/06 , A61K2035/124 , A61K2039/55511 , C07F9/098 , C12N5/0636 , C12N2501/23 , C12N2501/999 , Y02A50/412
摘要： The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among —CH3 and —CH2—CH3, Cat+ is an organic or inorganic cation, and n is an integer between 2 and 20, processes for the production thereof and uses thereof, in particular therapeutic uses and for activating primate Tγ9δ2 lymphocytes.
摘要翻译： 本发明提供了包含至少一种下式的磷酸卤代醇基团的化合物：其中X是选自I，Br，Cl中的卤素，R 1选自-CH 3和-CH 2 -CH 3，Cat +是有机或无机阳离子，和 n是2至20之间的整数，其制备方法及其用途，特别是治疗用途和用于激活灵长类的Tgamma9delta2淋巴细胞。
-
公开(公告)号：US07432253B2
公开(公告)日：2008-10-07
申请号：US11512855
申请日：2006-08-29
IPC分类号： A01N57/00 , C12N5/08 , C12N5/00 , A61K39/385 , A61K45/00
CPC分类号： C07H19/10 , A61K2035/124 , C07F9/65502 , C12N5/0636 , C12N2501/23 , C12N2501/999
摘要： The invention provides compounds comprising at least one phosphoepoxide group of the formula: where R1 is selected from among —CH3 and —CH2—CH3. Cat+ is an organic or inorganic cation, n is an integer between 2 and 20, processes for the production thereof and uses thereof, in particular therapeutic uses and for activating primate Tγ9δ2 lymphocytes.
摘要翻译： 本发明提供了包含至少一种下式的磷酸环氧基的化合物：其中R 1选自-CH 3 - 和-CH 2 -CH 3 >。 Cat +是有机或无机阳离子，n是2和20之间的整数，其生产方法及其用途，特别是治疗用途和激活灵长类的Tgamma9delta2淋巴细胞。
-
7.发明申请Methods and Compositions for Increasing the Efficiency of Therapeutic Antibodies Using Gamma Delta T Cell Activators 审中-公开使用Gamma Delta T细胞激活剂提高治疗性抗体效率的方法和组合物公开(公告)号：US20090304688A1
公开(公告)日：2009-12-10
申请号：US12307047
申请日：2007-07-12
IPC分类号： A61K39/395 , A61P35/00 , A61P31/12
CPC分类号： A61K31/663 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods and compositions for increasing the efficiency of therapeutic antibodies. More particularly, the invention relates to the use of a therapeutic antibody in combination with a γδ T cell activating compound or activated γδ T cells. thereby allowing a potentiation of γδ T cell cytotoxicity in mammalian subjects in order to enhance the efficiency of the treatment in human subjects, particularly through an increase of the depletion of targeted cells.
摘要翻译： 本发明涉及用于提高治疗性抗体效率的方法和组合物。 更具体地，本发明涉及治疗性抗体与Gammadelta T细胞活化化合物或活化的Gammadelta T细胞的组合的用途。 从而允许在哺乳动物受试者中增强gammadelta T细胞的细胞毒性，以提高人类受试者的治疗效果，特别是通过增加靶细胞的消耗。
-
公开(公告)号：US20060287274A1
公开(公告)日：2006-12-21
申请号：US11512855
申请日：2006-08-29
IPC分类号： A61K48/00 , A61K38/20 , A61K38/16 , A61K31/525 , A61K31/665 , A61K31/045 , C07F9/655
CPC分类号： C07H19/10 , A61K2035/124 , C07F9/65502 , C12N5/0636 , C12N2501/23 , C12N2501/999
摘要： The invention provides compounds comprising at least one phosphoepoxide group of the formula: where R1 is selected from among —CH3 and —CH2—CH3. Cat+ is an organic or inorganic cation, n is an integer between 2 and 20, processes for the production thereof and uses thereof, in particular therapeutic uses and for activating primate Tγ9δ2 lymphocytes.
摘要翻译： 本发明提供了包含至少一种下式的磷酸环氧基的化合物：其中R 1选自-CH 3 - 和-CH 2 -CH 3 >。 Cat +是有机或无机阳离子，n是2和20之间的整数，其生产方法及其用途，特别是治疗用途和激活灵长类的Tgamma9delta2淋巴细胞。
-
公开(公告)号：US20060287281A1
公开(公告)日：2006-12-21
申请号：US11512688
申请日：2006-08-30
IPC分类号： A61K31/675
CPC分类号： C07H19/10 , A61K31/66 , A61K39/00 , A61K45/06 , A61K2035/124 , A61K2039/55511 , C07F9/098 , C12N5/0636 , C12N2501/23 , C12N2501/999 , Y02A50/412
摘要： The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among —CH3 and —CH2—CH3, Cat+ is an organic or inorganic cation, and n is an integer between 2 and 20, processes for the production thereof and uses thereof, in particular therapeutic uses and for activating primate Tγ9δ2 lymphocytes.
-
公开(公告)号：US07109183B2
公开(公告)日：2006-09-19
申请号：US10682990
申请日：2003-10-14
CPC分类号： C07H19/10 , A61K31/66 , A61K39/00 , A61K45/06 , A61K2035/124 , A61K2039/55511 , C07F9/098 , C12N5/0636 , C12N2501/23 , C12N2501/999 , Y02A50/412
摘要： The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among —CH3 and —CH2—CH3, Cat+ is an organic or inorganic cation, and n is an integer between 2 and 20, processes for the production thereof and uses thereof, in particular therapeutic uses and for activating primate Tγ9δ2 lymphocytes.
摘要翻译： 本发明提供了包含至少一种下式的磷酸卤代醇基团的化合物：其中X是选自I，Br，Cl中的卤素，R 1选自-CH 3 - 和-CH 2 -CH 3，Cat +是有机或无机阳离子，n是2和20之间的整数，其生产方法及其用途，特别是治疗用途和激活灵长类动物 Tgamma9delta2淋巴细胞。
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.04 秒)
