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公开(公告)号：US20090187998A1
公开(公告)日：2009-07-23
申请号：US12313539
申请日：2008-11-22
申请人： Jeanne Y. Wei , Gohar Azhar , Xiaomin Zhang
发明人： Jeanne Y. Wei , Gohar Azhar , Xiaomin Zhang
CPC分类号： A61K49/0008 , G01N33/5008 , G01N33/5088 , G01N2333/4703
摘要： The invention provides a method of identifying candidate agents to test for treating heart failure involving diastolic impairment, the method comprising: testing an agent to determine whether it (a) binds to serum response factor (SRF), (b) reduces SRF binding to a serum response element (SRE), or (c) reduces SRF protein levels in a cell; wherein if the agent does one or more of (a), (b), and (c), it is identified as a candidate agent.
摘要翻译： 本发明提供了一种鉴定候选试剂以测试涉及舒张功能障碍的心力衰竭的方法，所述方法包括：测试试剂以确定其是否（a）是否结合血清反应因子（SRF），（b）降低SRF与 血清反应元件（SRE）或（c）降低细胞中的SRF蛋白水平; 其中如果代理人执行（a），（b）和（c）中的一个或多个，则将其识别为候选代理。
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公开(公告)号：US08043801B2
公开(公告)日：2011-10-25
申请号：US12313539
申请日：2008-11-22
申请人： Jeanne Y. Wei , Gohar Azhar , Xiaomin Zhang
发明人： Jeanne Y. Wei , Gohar Azhar , Xiaomin Zhang
CPC分类号： A61K49/0008 , G01N33/5008 , G01N33/5088 , G01N2333/4703
摘要： The invention provides a method of identifying candidate agents to test for treating heart failure involving diastolic impairment, the method comprising: testing an agent to determine whether it (a) binds to serum response factor (SRF), (b) reduces SRF binding to a serum response element (SRE), or (c) reduces SRF protein levels in a cell; wherein if the agent does one or more of (a), (b), and (c), it is identified as a candidate agent.
摘要翻译： 本发明提供了一种鉴定候选试剂以测试涉及舒张功能障碍的心力衰竭的方法，所述方法包括：测试试剂以确定其是否（a）是否结合血清反应因子（SRF），（b）降低SRF与 血清反应元件（SRE）或（c）降低细胞中的SRF蛋白水平; 其中如果代理人执行（a），（b）和（c）中的一个或多个，则将其识别为候选代理。
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公开(公告)号：US20090035850A1
公开(公告)日：2009-02-05
申请号：US12283347
申请日：2008-09-11
申请人： Jeanne Y. Wei , Xiaomin Zhang
发明人： Jeanne Y. Wei , Xiaomin Zhang
CPC分类号： C07K14/4702 , A61K38/00
摘要： The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.
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4.发明授权P49/STRAP is a novel protein involved in gene regulation and cell proliferation 有权P49 / STRAP是一种参与基因调控和细胞增殖的新型蛋白质公开(公告)号：US07498411B2
公开(公告)日：2009-03-03
申请号：US11726699
申请日：2007-03-22
申请人： Jeanne Y. Wei , Xiaomin Zhang
发明人： Jeanne Y. Wei , Xiaomin Zhang
CPC分类号： C07K14/4702 , A61K38/00
摘要： The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.
摘要翻译： 本发明提供分离的p49 / STRAP蛋白和编码p49 / STRAP蛋白的分离的核酸。 本发明人发现了一种新的蛋白质，命名为p49 / STRAP，其在哺乳动物的心脏组织和其他组织中表达。 p49 / STRAP蛋白与血清反应因子（SRF）结合并调节心脏中SRF反应基因的转录。 还发现p49 / STRAP抑制肿瘤细胞增殖，因此本发明通过使细胞与p49 / STRAP接触来提供抑制癌细胞增殖的方法。
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5.发明授权p49/STRAP is a novel protein involved in gene regulation and cell proliferation 有权p49 / STRAP是一种涉及基因调控和细胞增殖的新型蛋白质公开(公告)号：US08232098B2
公开(公告)日：2012-07-31
申请号：US12283347
申请日：2008-09-11
申请人： Jeanne Y. Wei , Xiaomin Zhang
发明人： Jeanne Y. Wei , Xiaomin Zhang
CPC分类号： C07K14/4702 , A61K38/00
摘要： The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.
摘要翻译： 本发明提供分离的p49 / STRAP蛋白和编码p49 / STRAP蛋白的分离的核酸。 本发明人发现了一种新的蛋白质，命名为p49 / STRAP，其在哺乳动物的心脏组织和其他组织中表达。 p49 / STRAP蛋白与血清反应因子（SRF）结合并调节心脏中SRF反应基因的转录。 还发现p49 / STRAP抑制肿瘤细胞增殖，因此本发明通过使细胞与p49 / STRAP接触来提供抑制癌细胞增殖的方法。
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6.发明授权p49/STRAP is a novel protein involved in gene regulation and cell proliferation 有权p49 / STRAP是一种涉及基因调控和细胞增殖的新型蛋白质公开(公告)号：US07211427B2
公开(公告)日：2007-05-01
申请号：US11225270
申请日：2005-09-13
申请人： Jeanne Y. Wei , Xiaomin Zhang
发明人： Jeanne Y. Wei , Xiaomin Zhang
CPC分类号： C07K14/4702 , A61K38/00
摘要： The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.
摘要翻译： 本发明提供分离的p49 / STRAP蛋白和编码p49 / STRAP蛋白的分离的核酸。 本发明人发现了一种新的蛋白质，命名为p49 / STRAP，其在哺乳动物的心脏组织和其他组织中表达。 p49 / STRAP蛋白与血清反应因子（SRF）结合并调节心脏中SRF反应基因的转录。 还发现p49 / STRAP抑制肿瘤细胞增殖，因此本发明通过使细胞与p49 / STRAP接触来提供抑制癌细胞增殖的方法。
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