公开(公告)号：US20130057871A1

公开(公告)日：2013-03-07

申请号：US13640663

申请日：2011-03-08

申请人： Jeehyun Kim ,  Hee-Young Jung ,  Chango Lee ,  Seung-Yeol Lee

发明人： Jeehyun Kim ,  Hee-Young Jung ,  Chango Lee ,  Seung-Yeol Lee

IPC分类号： G01B9/02

CPC分类号： G01N21/4795

摘要： Disclosed is a method and apparatus for the non-invasive selection of high-quality seeds, based on optical coherence tomography, by which pathogen-infected and pathogen-free seeds can be discriminated in a non-invasive manner. The apparatus is operated by the processes of scanning a seed of diagnostic interest in a non-invasive manner using an optical coherence tomographic unit; processing interference signals of the scanned tomographic images to produce tomographic image data of the seed of diagnostic interest; analyzing the tomographic image data; comparing the analyzed tomographic image data with preset reference tomographic image data; diagnosing the seed of diagnostic interest as a pathogen-infected or pathogen-free seed according to the comparison data; and selecting high-quality seeds according to the diagnosis data. It can screen high-quality seeds with rapidity, convenience, and accuracy at a low cost and is industrially applicable, making a great contribution to agricultural quarantine inspection.

摘要翻译： 公开了一种基于光学相干断层扫描技术非侵入性选择高质量种子的方法和装置，通过该方法和装置可以以非侵入性的方式区分病原体感染和无病原体的种子。 该装置通过使用光学相干断层摄影单元以非侵入性方式扫描诊断感兴趣的种子的过程来操作; 处理扫描的断层图像的干涉信号，以产生诊断感兴趣的种子的断层图像数据; 分析断层图像数据; 将分析的断层图像数据与预设的参考断层图像数据进行比较; 根据比较数据将诊断感兴趣的种子诊断为病原体感染或无病原体的种子; 并根据诊断数据选择优质种子。 可以低成本筛选高品质种子，速度快，方便，准确，在工业上适用，对农业检疫工作做出了重大贡献。

公开(公告)号：US20130051627A1

公开(公告)日：2013-02-28

申请号：US13583655

申请日：2011-03-08

申请人： Jeehyun Kim ,  Hee Young Jung ,  Changho Lee ,  Seung-Yeol Lee

发明人： Jeehyun Kim ,  Hee Young Jung ,  Changho Lee ,  Seung-Yeol Lee

IPC分类号： G01B9/02 ,  G06K9/00

CPC分类号： G01B9/02091 ,  G01N21/4795 ,  G01N21/84 ,  G01N33/0098 ,  G01N2021/8466

摘要： The present invention relates to a non-invasive early diagnostic method and device that allows an early diagnosis of Marssonina blotch disease, which infects apple tree leaves, before the occurrence of lesions to enable early prevention of apple Marssonina blotch disease. The method and device of the present invention comprise the following steps: irradiating a broadband light source on an apple tree leaf undergoing diagnosis by means of optical coherence tomography; detecting interference signals from light reflected from the apple tree leaf undergoing diagnosis and light reflected from a reference arm; signal processing the interference signals, which have been detected through optical coherence tomography by means of a signal processing unit; obtaining digital tomographic image data on the apple tree leaf undergoing diagnosis; analyzing the digital tomographic image by means of a diagnostic unit; and observing the boundary of at least two tissues, wherein the apple tree leaf undergoing diagnosis is considered to be healthy and uninfected with Marssonina blotch disease if the boundary between at least two tissues is clearly defined, and wherein the apple tree leaf undergoing diagnosis is considered to be infected with Marssonina blotch disease if the boundary between at least two tissues is not clearly defined.

摘要翻译： 本发明涉及一种非侵入性早期诊断方法和装置，其能够在发生病变之前早期诊断感染苹果树叶的马尔辛纳斯斑点病，以便能够早日预防苹果马尔森纳斑疹病。 本发明的方法和装置包括以下步骤：通过光学相干断层扫描将宽带光源照射在经历诊断的苹果树叶上; 检测来自经历诊断的苹果树叶反射的光的干扰信号和从参考臂反射的光; 信号处理通过信号处理单元通过光学相干断层摄影检测的干扰信号; 在经历诊断的苹果树叶上获取数字断层图像数据; 通过诊断单元分析数字断层图像; 并且观察至少两个组织的边界，其中如果清楚地限定了至少两个组织之间的边界，则认为正在进行诊断的苹果树叶是健康的并且没有感染Marssonina斑点病，并且其中考虑正在诊断的苹果树叶 如果至少两个组织之间的边界没有明确定义，则感染Marssonina斑点病。

公开(公告)号：US09513217B2

公开(公告)日：2016-12-06

申请号：US13640663

申请日：2011-03-08

申请人： Jeehyun Kim ,  Hee-Young Jung ,  Changho Lee ,  Seung-Yeol Lee

发明人： Jeehyun Kim ,  Hee-Young Jung ,  Changho Lee ,  Seung-Yeol Lee

IPC分类号： G01N21/47

CPC分类号： G01N21/4795

摘要： Disclosed is a method and apparatus for the non-invasive selection of high-quality seeds, based on optical coherence tomography, by which pathogen-infected and pathogen-free seeds can be discriminated in a non-invasive manner. The apparatus is operated by the processes of scanning a seed of diagnostic interest in a non-invasive manner using an optical coherence tomographic unit; processing interference signals of the scanned tomographic images to produce tomographic image data of the seed of diagnostic interest; analyzing the tomographic image data; comparing the analyzed tomographic image data with preset reference tomographic image data; diagnosing the seed of diagnostic interest as a pathogen-infected or pathogen-free seed according to the comparison data; and selecting high-quality seeds according to the diagnosis data. It can screen high-quality seeds with rapidity, convenience, and accuracy at a low cost and is industrially applicable, making a great contribution to agricultural quarantine inspection.

摘要翻译： 公开了一种基于光学相干断层扫描技术非侵入性选择高质量种子的方法和装置，通过该方法和装置可以以非侵入性的方式区分病原体感染和无病原体的种子。 该装置通过使用光学相干断层摄影单元以非侵入性方式扫描诊断感兴趣的种子的过程来操作; 处理扫描的断层图像的干涉信号以产生诊断感兴趣的种子的断层图像数据; 分析断层图像数据; 将分析的断层图像数据与预设的参考断层图像数据进行比较; 根据比较数据将诊断感兴趣的种子诊断为病原体感染或无病原体的种子; 并根据诊断数据选择优质种子。 可以低成本筛选高品质种子，速度快，方便，准确，在工业上适用，对农业检疫工作做出了重大贡献。

公开(公告)号：US08885872B2

公开(公告)日：2014-11-11

申请号：US13583655

申请日：2011-03-08

申请人： Jeehyun Kim ,  Hee Young Jung ,  Changho Lee ,  Seung-Yeol Lee

发明人： Jeehyun Kim ,  Hee Young Jung ,  Changho Lee ,  Seung-Yeol Lee

IPC分类号： G06K9/00 ,  G01N21/84 ,  G01N21/47 ,  G01N33/00 ,  G01B9/02

CPC分类号： G01B9/02091 ,  G01N21/4795 ,  G01N21/84 ,  G01N33/0098 ,  G01N2021/8466

摘要： The present invention relates to a non-invasive early diagnostic method and device that allows an early diagnosis of Marssonina blotch disease, which infects apple tree leaves, before the occurrence of lesions to enable early prevention of apple Marssonina blotch disease. The method and device of the present invention comprise the following steps: irradiating a broadband light source on an apple tree leaf undergoing diagnosis by means of optical coherence tomography; detecting interference signals from light reflected from the apple tree leaf undergoing diagnosis and light reflected from a reference arm; signal processing the interference signals, which have been detected through optical coherence tomography by means of a signal processing unit; obtaining digital tomographic image data on the apple tree leaf undergoing diagnosis; analyzing the digital tomographic image by means of a diagnostic unit; and observing the boundary of at least two tissues, wherein the apple tree leaf undergoing diagnosis is considered to be healthy and uninfected with Marssonina blotch disease if the boundary between at least two tissues is clearly defined, and wherein the apple tree leaf undergoing diagnosis is considered to be infected with Marssonina blotch disease if the boundary between at least two tissues is not clearly defined.

摘要翻译： 本发明涉及一种非侵入性早期诊断方法和装置，其能够在发生病变之前早期诊断感染苹果树叶的马尔辛纳斯斑点病，以便能够早日预防苹果马尔森纳斑疹病。 本发明的方法和装置包括以下步骤：通过光学相干断层扫描将宽带光源照射在经历诊断的苹果树叶上; 检测来自经历诊断的苹果树叶反射的光的干扰信号和从参考臂反射的光; 信号处理通过信号处理单元通过光学相干断层摄影检测的干扰信号; 在经历诊断的苹果树叶上获取数字断层图像数据; 通过诊断单元分析数字断层图像; 并且观察至少两个组织的边界，其中如果清楚地限定了至少两个组织之间的边界，则认为正在进行诊断的苹果树叶是健康的并且没有感染Marssonina斑点病，并且其中考虑正在诊断的苹果树叶 如果至少两个组织之间的边界没有明确定义，则感染Marssonina斑点病。

公开(公告)号：US20060241493A1

公开(公告)日：2006-10-26

申请号：US10548982

申请日：2004-04-23

申请人： Marc Feldman ,  Thomas Mihner ,  Shaochen Chen ,  Jeehyun Kim ,  Li-Hsin Han ,  Jung-Hwan Oh ,  Ho Lee

发明人： Marc Feldman ,  Thomas Mihner ,  Shaochen Chen ,  Jeehyun Kim ,  Li-Hsin Han ,  Jung-Hwan Oh ,  Ho Lee

IPC分类号： A61B6/00

CPC分类号： A61B5/0084 ,  A61B1/00183 ,  A61B1/3137 ,  A61B5/0066 ,  A61B5/6852 ,  A61B8/12 ,  A61B8/4461 ,  A61N2007/0091

摘要： A catheter imaging probe for a patient. The probe includes a conduit through with energy is transmitted. The probe includes a first portion through which the conduit extends. The probe includes a second portion which rotates relative to the conduit to redirect the energy from the conduit. A method for imaging a patient. The method includes the steps of inserting a catheter into the patient. There is the step of rotating a second portion of the catheter relative to a conduit extending through a first portion of the catheter, which redirects the energy transmitted through the conduit to the patient and receives the energy reflected back to the second portion from the patient and redirects the reflected energy to the conduit.

公开(公告)号：US08540627B2

公开(公告)日：2013-09-24

申请号：US12832001

申请日：2010-07-07

申请人： Marc D. Feldman ,  Thomas E. Milner ,  Jung Hwan Oh ,  Eunha Kim ,  Karthik Kumar ,  Chris Condit ,  Robert Grant ,  Nate Kemp ,  Jeehyun Kim ,  Shaochen Chen ,  Li-Hsin Han

发明人： Marc D. Feldman ,  Thomas E. Milner ,  Jung Hwan Oh ,  Eunha Kim ,  Karthik Kumar ,  Chris Condit ,  Robert Grant ,  Nate Kemp ,  Jeehyun Kim ,  Shaochen Chen ,  Li-Hsin Han

IPC分类号： A61B1/00 ,  A61B1/07

CPC分类号： A61B5/0073 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852

摘要： The embodiments disclosed herein is related to a system for optical coherence tomographic imaging of turbid (i.e., scattering) materials utilizing multiple channels of information. The multiple channels of information may be comprised and encompass spatial, angle, spectral and polarization domains. More specifically, the embodiments disclosed herein is related to methods and apparatus for utilizing optical sources, systems or receivers capable of providing (source), processing (system) or recording (receiver) a multiplicity of channels of spectral information for optical coherence tomographic imaging of turbid materials. In these methods and apparatus the multiplicity of channels of spectral information that can be provided by the source, processed by the system, or recorded by the receiver are used to convey simultaneously spatial, spectral or polarimetric information relating to the turbid material being imaged tomographically. The multichannel optical coherence tomographic methods can be incorporated into an endoscopic probe for imaging a patient. The endoscope comprises an optical fiber array and can comprise a plurality of optical fibers adapted to be disposed in the patient. The optical fiber array transmits the light from the light source into the patient, and transmits the light reflected by the patient out of the patient. The plurality of optical fibers in the array is in optical communication with the light source. The multichannel optical coherence tomography system comprises a detector for receiving the light from the array and analyzing the light. The methods and apparatus may be applied for imaging a vessel, biliary, GU and/or GI tract of a patient.

摘要翻译： 本文公开的实施例涉及利用多个信道信道的浑浊（即散射）材料的光学相干断层成像系统。 可以包括多个信道信道并且包括空间，角度，频谱和极化域。 更具体地说，这里公开的实施例涉及用于利用光源，系统或接收器的方法和装置，该光源，系统或接收器能够提供（源），处理（系统）或记录（接收）多个光谱信息通道，用于光学相干断层成像 浑浊的材料。 在这些方法和装置中，可以由源提供的，由系统处理或由接收机记录的光谱信息的多个信道的多样性被用于同时传送与被层析成像的浑浊材料有关的空间，光谱或偏振信息。 多通道光学相干断层摄影方法可以并入用于成像患者的内窥镜探针中。 内窥镜包括光纤阵列，并且可以包括适于设置在患者体内的多根光纤。 光纤阵列将来自光源的光透射到患者体内，并将患者反射的光透射出患者。 阵列中的多个光纤与光源光学通信。 多通道光学相干断层摄影系统包括用于从阵列接收光并分析光的检测器。 该方法和装置可以应用于对患者的血管，胆管，GU和/或胃肠道进行成像。

公开(公告)号：US20110009701A1

公开(公告)日：2011-01-13

申请号：US12832001

申请日：2010-07-07

申请人： Marc D. Feldman ,  Thomas E. Milner ,  Jung Hwan Oh ,  Eunha Kim ,  Karthik Kumar ,  Chris Condit ,  Robert Grant ,  Nate Kemp ,  Jeehyun Kim ,  Shaochen Chen ,  Li-Hsin Han

发明人： Marc D. Feldman ,  Thomas E. Milner ,  Jung Hwan Oh ,  Eunha Kim ,  Karthik Kumar ,  Chris Condit ,  Robert Grant ,  Nate Kemp ,  Jeehyun Kim ,  Shaochen Chen ,  Li-Hsin Han

IPC分类号： A61B1/07

CPC分类号： A61B5/0073 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852

摘要： The embodiments disclosed herein is related to a system for optical coherence tomographic imaging of turbid (i.e., scattering) materials utilizing multiple channels of information. The multiple channels of information may be comprised and encompass spatial, angle, spectral and polarization domains. More specifically, the embodiments disclosed herein is related to methods and apparatus for utilizing optical sources, systems or receivers capable of providing (source), processing (system) or recording (receiver) a multiplicity of channels of spectral information for optical coherence tomographic imaging of turbid materials. In these methods and apparatus the multiplicity of channels of spectral information that can be provided by the source, processed by the system, or recorded by the receiver are used to convey simultaneously spatial, spectral or polarimetric information relating to the turbid material being imaged tomographically. The multichannel optical coherence tomographic methods can be incorporated into an endoscopic probe for imaging a patient. The endoscope comprises an optical fiber array and can comprise a plurality of optical fibers adapted to be disposed in the patient. The optical fiber array transmits the light from the light source into the patient, and transmits the light reflected by the patient out of the patient. The plurality of optical fibers in the array is in optical communication with the light source. The multichannel optical coherence tomography system comprises a detector for receiving the light from the array and analyzing the light. The methods and apparatus may be applied for imaging a vessel, biliary, GU and/or GI tract of a patient.

摘要翻译： 本文公开的实施例涉及利用多个信道信道的浑浊（即散射）材料的光学相干断层成像系统。 可以包括多个信道信道并且包括空间，角度，频谱和极化域。 更具体地说，这里公开的实施例涉及用于利用光源，系统或接收器的方法和装置，该光源，系统或接收器能够提供（源），处理（系统）或记录（接收）多个光谱信息通道，用于光学相干断层成像 浑浊的材料。 在这些方法和装置中，可以由源提供的，由系统处理或由接收机记录的光谱信息的多个信道的多样性被用于同时传送与被层析成像的浑浊材料有关的空间，光谱或偏振信息。 多通道光学相干断层摄影方法可以并入用于成像患者的内窥镜探针中。 内窥镜包括光纤阵列，并且可以包括适于设置在患者体内的多根光纤。 光纤阵列将来自光源的光透射到患者体内，并将患者反射的光透射出患者。 阵列中的多个光纤与光源光学通信。 多通道光学相干断层摄影系统包括用于从阵列接收光并分析光的检测器。 该方法和装置可以应用于对患者的血管，胆管，GU和/或胃肠道进行成像。

公开(公告)号：US20070015969A1

公开(公告)日：2007-01-18

申请号：US11446683

申请日：2006-06-05

申请人： Marc Feldman ,  Thomas Milner ,  Jung Oh ,  Eunha Kim ,  Karthik Kumar ,  Chris Condit ,  Robert Grant ,  Nate Kemp ,  Jeehyun Kim ,  Shaochen Chen ,  Li-Hsin Han

发明人： Marc Feldman ,  Thomas Milner ,  Jung Oh ,  Eunha Kim ,  Karthik Kumar ,  Chris Condit ,  Robert Grant ,  Nate Kemp ,  Jeehyun Kim ,  Shaochen Chen ,  Li-Hsin Han

IPC分类号： A61B1/06

CPC分类号： A61B5/0073 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852

摘要： The present invention is related to a system for optical coherence tomographic imaging of turbid (i.e., scattering) materials utilizing multiple channels of information. The multiple channels of information may be comprised and encompass spatial, angle, spectral and polarization domains. More specifically, the present invention is related to methods and apparatus for utilizing optical sources, systems or receivers capable of providing (source), processing (system) or recording (receiver) a multiplicity of channels of spectral information for optical coherence tomographic imaging of turbid materials. In these methods and apparatus the multiplicity of channels of spectral information that can be provided by the source, processed by the system, or recorded by the receiver are used to convey simultaneously spatial, spectral or polarimetric information relating to the turbid material being imaged tomographically. The multichannel optical coherence tomographic methods can be incorporated into an endoscopic probe for imaging a patient. The endoscope comprises an optical fiber array and can comprise a plurality of optical fibers adapted to be disposed in the patient. The optical fiber array transmits the light from the light source into the patient, and transmits the light reflected by the patient out of the patient. The plurality of optical fibers in the array are in optical communication with the light source. The multichannel optical coherence tomography system comprises a detector for receiving the light from the array and analyzing the light. The methods and apparatus may be applied for imaging a vessel, biliary, GU and/or GI tract of a patient.

摘要翻译： 本发明涉及一种利用多信道信息的浑浊（即散射）材料的光学相干断层成像系统。 可以包括多个信道信道并且包括空间，角度，频谱和极化域。 更具体地，本发明涉及用于利用光源，系统或接收机的方法和装置，所述光源，系统或接收机能够提供（源），处理（系统）或记录（接收）多个频谱信息的信道，用于混浊的光学相干断层成像 材料 在这些方法和装置中，可以由源提供的，由系统处理或由接收机记录的光谱信息的多个信道的多样性被用于同时传送与被层析成像的浑浊材料有关的空间，光谱或偏振信息。 多通道光学相干断层摄影方法可以并入用于成像患者的内窥镜探针中。 内窥镜包括光纤阵列，并且可以包括适于设置在患者体内的多根光纤。 光纤阵列将来自光源的光透射到患者体内，并将患者反射的光透射出患者。 阵列中的多根光纤与光源光通信。 多通道光学相干断层摄影系统包括用于从阵列接收光并分析光的检测器。 该方法和装置可以应用于对患者的血管，胆管，GU和/或胃肠道进行成像。

公开(公告)号：US07783337B2

公开(公告)日：2010-08-24

申请号：US11446683

申请日：2006-06-05

申请人： Marc D. Feldman ,  Thomas E. Milner ,  Jung Hwan Oh ,  Eunha Kim ,  Karthik Kumar ,  Chris Condit ,  Robert Grant ,  Nate Kemp ,  Jeehyun Kim ,  Shaochen Chen ,  Li-Hsin Han

发明人： Marc D. Feldman ,  Thomas E. Milner ,  Jung Hwan Oh ,  Eunha Kim ,  Karthik Kumar ,  Chris Condit ,  Robert Grant ,  Nate Kemp ,  Jeehyun Kim ,  Shaochen Chen ,  Li-Hsin Han

IPC分类号： A61B5/05

CPC分类号： A61B5/0073 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852

摘要： An apparatus is disclosed for studying an object based on at least one of polarization, space, position or angle of light that has reflected from the object. An optical tomographic instrumentation of the apparatus includes a light source coupled to a source path, a sample path, a reference path, and a detection path, wherein the light source generates a spectrally resolved bandwidth. The spectrally resolved bandwidth includes a plurality of spectrally resolved cells and a detector in the detection path for analyzing light reflected from an object in the sample path and the light reflected in the reference path based upon at least one of the polarization, spatial relationship, position or angle domains.

摘要翻译： 公开了一种用于基于从物体反射的光的偏振，空间，位置或角度中的至少一个来研究物体的装置。 该设备的光学断层摄影仪器包括耦合到源路径的光源，采样路径，参考路径和检测路径，其中光源产生频谱分辨的带宽。 光谱解析的带宽包括多个光谱分辨的单元和检测路径中的检测器，用于分析从采样路径中的物体反射的光和基准路径中反射的光，基于偏振，空间关系，位置 或角域。

公开(公告)号：US20100168587A1

公开(公告)日：2010-07-01

申请号：US12638927

申请日：2009-12-15

申请人： Marc D. Feldman ,  Thomas E. Milner ,  Shaochen Chen ,  Jeehyun Kim ,  Li-Hsin Han ,  Jung-Hwan Oh ,  Ho Lee

发明人： Marc D. Feldman ,  Thomas E. Milner ,  Shaochen Chen ,  Jeehyun Kim ,  Li-Hsin Han ,  Jung-Hwan Oh ,  Ho Lee

IPC分类号： A61B6/00

CPC分类号： A61B5/0084 ,  A61B1/00183 ,  A61B1/3137 ,  A61B5/0066 ,  A61B5/6852 ,  A61B8/12 ,  A61B8/4461 ,  A61N2007/0091

摘要： A catheter imaging probe for a patient. The probe includes a conduit through with energy is transmitted. The probe includes a first portion through which the conduit extends. The probe includes a second portion which rotates relative to the conduit to redirect the energy from the conduit. A method for imaging a patient. The method includes the steps of inserting a catheter into the patient. There is the step of rotating a second portion of the catheter relative to a conduit extending through a first portion of the catheter, which redirects the energy transmitted through the conduit to the patient and receives the energy reflected back to the second portion from the patient and redirects the reflected energy to the conduit.

摘要翻译： 用于患者的导管成像探针。 探头包括通过能量传输的导管。 探针包括导管延伸通过的第一部分。 探针包括第二部分，其相对于导管旋转以重新引导来自导管的能量。 一种用于对患者进行成像的方法。 该方法包括将导管插入患者体内的步骤。 存在使导管的第二部分相对于延伸穿过导管的第一部分的导管旋转的步骤，其将通过导管传输的能量重定向到患者并且接收从患者反射回第二部分的能量， 将反射的能量重定向到导管。