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1.发明授权Sensitivity and specificity of pulmonary edema detection when using transthoracic impedance 有权使用经胸阻塞时肺水肿检测的灵敏度和特异性公开(公告)号：US09089275B2
公开(公告)日：2015-07-28
申请号：US11126723
申请日：2005-05-11
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0537 , A61B5/4869 , A61M2230/40 , A61M2230/65 , A61N1/36521 , A61N1/37282
摘要： This patent document discusses, among other things, systems, devices, and methods for enhancing detection of pulmonary edema using, in addition to thoracic impedance, one or a combination of: physiologic information about a subject, at least one statistical parameter, a user-programmable detection level, at least one parameter associated with a previous pulmonary edema event, and patient symptom information about the subject. In one example, a (base) thoracic impedance threshold is modified to an adjusted thoracic impedance threshold. The adjusted thoracic impedance threshold provides an increased sensitivity of pulmonary edema detection as compared to the base thoracic impedance threshold. In another example, an alert is provided to a subject, a caregiver, or other user based on a pulmonary edema indication determined by the present systems, devices, and methods. In a further example, a therapy (provided to the subject) is adjusted or initiated in response to the pulmonary edema indication.
摘要翻译： 该专利文献尤其涉及用于增强肺水肿检测的系统，装置和方法，除胸部阻抗之外，还包括以下之一或组合：关于受试者的生理信息，至少一个统计参数， 可编程检测水平，与先前的肺水肿事件相关联的至少一个参数，以及关于受试者的患者症状信息。 在一个示例中，（基底）胸部阻抗阈值被修改为经调整的胸部阻抗阈值。 与基础胸廓阻抗阈值相比，经调整的胸廓阻抗阈值提供了肺水肿检测的灵敏度增加。 在另一示例中，基于由本系统，设备和方法确定的肺水肿指示，向受检者，照顾者或其他用户提供警报。 在另一个实例中，响应于肺水肿指示调整或启动治疗（提供给受试者）。
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2.发明授权Calibration of impedance monitoring of respiratory volumes using thoracic D.C. impedance 有权使用胸部直流阻抗校正阻抗监测呼吸体积公开(公告)号：US07603170B2
公开(公告)日：2009-10-13
申请号：US11114661
申请日：2005-04-26
CPC分类号： A61N1/36521 , A61B5/0809 , A61B2560/0223 , A61N1/3756
摘要： A system includes an implantable medical device that includes a trans-thoracic impedance measurement circuit providing a trans-thoracic impedance signal of a subject. A controller is coupled to the trans-thoracic impedance circuit. The controller extracts a respiration signal from the trans-thoracic impedance signal, measures a breathing volume of the subject using the amplitude of the respiration signal and a breathing volume calibration factor, computes an adjusted breathing volume calibration factor using a reference baseline value of the trans-thoracic impedance and a measured baseline value of the trans-thoracic impedance, and computes a calibrated breathing volume using the adjusted breathing volume calibration factor.
摘要翻译： 一种系统包括可植入医疗装置，其包括提供受试者的胸部阻抗信号的跨胸阻抗测量电路。 控制器耦合到跨胸阻抗电路。 控制器从胸部阻抗信号中提取呼吸信号，使用呼吸信号的幅度和呼吸音量校准因子来测量受试者的呼吸体积，使用反式信号的参考基准值计算调整后的呼吸量校准因子 胸廓阻抗和经胸阻抗的测量基线值，并使用调整后的呼吸量校准因子计算校准呼吸量。
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3.发明授权公开(公告)号：US07907997B2
公开(公告)日：2011-03-15
申请号：US11126689
申请日：2005-05-11
CPC分类号： A61B5/0537 , A61B5/0002 , A61B5/0538 , A61B5/4869 , A61B5/4878
摘要： This patent document discusses, among other things, systems, devices, and methods for enhancing detection of pulmonary edema using, in addition to thoracic impedance, one or a combination of: physiologic information about a subject, at least one statistical parameter, a user-programmable detection level, at least one parameter associated with a previous pulmonary edema event, and patient symptom information about the subject. In one example, a (base) thoracic impedance threshold is modified to an adjusted thoracic impedance threshold. The adjusted thoracic impedance threshold provides an increased sensitivity of pulmonary edema detection as compared to the base thoracic impedance threshold. In another example, an alert is provided to a subject, a caregiver, or other user based on a pulmonary edema indication determined by the present systems, devices, and methods. In a further example, a therapy (provided to the subject) is adjusted or initiated in response to the pulmonary edema indication.
摘要翻译： 该专利文献尤其涉及用于增强肺水肿检测的系统，装置和方法，除胸部阻抗之外，还包括以下之一或组合：关于受试者的生理信息，至少一个统计参数， 可编程检测水平，与先前的肺水肿事件相关联的至少一个参数，以及关于受试者的患者症状信息。 在一个示例中，（基底）胸部阻抗阈值被修改为经调整的胸部阻抗阈值。 与基础胸廓阻抗阈值相比，经调整的胸廓阻抗阈值提供了肺水肿检测的灵敏度增加。 在另一示例中，基于由本系统，设备和方法确定的肺水肿指示，向受检者，照顾者或其他用户提供警报。 在另一个实例中，响应于肺水肿指示调整或启动治疗（提供给受试者）。
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公开(公告)号：US07340296B2
公开(公告)日：2008-03-04
申请号：US11132109
申请日：2005-05-18
IPC分类号： A61B5/05
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0535 , A61B5/1116 , A61B5/4869 , A61N1/36521 , A61N1/36535
摘要： This patent document discusses systems, devices, and methods for increasing a sensitivity or specificity of thoracic fluid detection in a subject and differentiating between pleural effusion and pulmonary edema. In one example, a thoracic impedance measurement circuit senses a thoracic impedance signal. In another example, a processor receives the thoracic impedance signal and determines whether such thoracic impedance signal is “significant.” A significant thoracic impedance signal indicates the presence of thoracic fluid and may be recognized by comparing the thoracic impedance signal (or variation thereof) to a thoracic impedance threshold. When a significant thoracic impedance signal is recognized, the processor is adapted to detect one or both of: a pleural effusion indication and a pulmonary edema indication using one or a combination of: physiologic information, patient symptom information, and posture information. In another example, the thoracic impedance threshold is adjusted using such physiologic, patient symptom, or posture information.
摘要翻译： 该专利文献讨论了用于增加受试者胸部液体检测的敏感性或特异性并区分胸腔积液和肺水肿的系统，装置和方法。 在一个示例中，胸部阻抗测量电路感测胸部阻抗信号。 在另一示例中，处理器接收胸部阻抗信号并确定这种胸部阻抗信号是否“显着”。 显着的胸部阻抗信号表示胸腔液的存在，并且可以通过将胸部阻抗信号（或其变化）与胸部阻抗阈值进行比较来识别。 当识别出显着的胸部阻抗信号时，处理器适合于使用生理信息，患者症状信息和姿势信息中的一个或组合来检测胸腔积液指示和肺水肿指示之一或两者。 在另一个例子中，使用这种生理，患者症状或姿势信息来调整胸阻抗阈值。
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5.发明授权Implantable devices and methods using frequency-domain analysis of thoracic signal 有权可植入装置和方法使用胸腔信号的频域分析公开(公告)号：US07186220B2
公开(公告)日：2007-03-06
申请号：US10612387
申请日：2003-07-02
申请人： Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni , John Hatlestad
发明人： Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni , John Hatlestad
IPC分类号： A61B5/08
CPC分类号： A61B5/0535 , A61B5/08 , A61B5/7257 , A61N1/36521 , A61N1/36592
摘要： This document describes, among other things, systems, devices, and methods that use frequency domain analysis of a thoracic signal. One example uses frequency domain analysis for discriminating between different pulmonary physiological states. Examples of breathing states include normal breathing, periodic breathing, Cheyne-Stokes breathing, obstructed respiration, restrictive respiration, and pulmonary edema. The frequency domain analysis may also be used for performing heart rate variability (HRV) diagnostics. In one example, a frequency domain adaptive filter implements a variable cutoff frequency for separating heart contraction spectral content and other spectral content from lower frequency respiration spectral content and other lower frequency spectral content.
摘要翻译： 本文档描述了使用胸部信号的频域分析的系统，设备和方法。 一个例子使用频域分析来区分不同的肺部生理状态。 呼吸状态的例子包括正常呼吸，定期呼吸，切尼 - 斯托克斯呼吸，阻塞呼吸，限制性呼吸和肺水肿。 频域分析也可用于执行心率变异性（HRV）诊断。 在一个示例中，频域自适应滤波器实现用于将心脏收缩频谱内容和其他频谱内容与较低频率呼吸频谱内容和其他较低频谱内容分离的可变截止频率。
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6.发明申请CALIBRATION OF IMPEDANCE MONITORING OF RESPIRATORY VOLUMES USING THORACIC D.C. IMPEDANCE 有权使用THORACIC D.C.阻抗校正呼吸道阻力监测公开(公告)号：US20090326599A1
公开(公告)日：2009-12-31
申请号：US12557372
申请日：2009-09-10
CPC分类号： A61N1/36521 , A61B5/0809 , A61B2560/0223 , A61N1/3756
摘要： A system includes an implantable medical device that includes a trans-thoracic impedance measurement circuit providing a trans-thoracic impedance signal of a subject. A controller is coupled to the trans-thoracic impedance circuit. The controller extracts a respiration signal from the trans-thoracic impedance signal, measures a breathing volume of the subject using the amplitude of the respiration signal and a breathing volume calibration factor, computes an adjusted breathing volume calibration factor using a reference baseline value of the trans-thoracic impedance and a measured baseline value of the trans-thoracic impedance, and computes a calibrated breathing volume using the adjusted breathing volume calibration factor.
摘要翻译： 一种系统包括可植入医疗装置，其包括提供受试者的胸部阻抗信号的跨胸阻抗测量电路。 控制器耦合到跨胸阻抗电路。 控制器从胸部阻抗信号中提取呼吸信号，使用呼吸信号的幅度和呼吸音量校准因子来测量受试者的呼吸体积，使用反式信号的参考基准值计算调整后的呼吸量校准因子 胸廓阻抗和经胸阻抗的测量基线值，并使用调整后的呼吸量校准因子计算校准呼吸量。
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公开(公告)号：US07979115B2
公开(公告)日：2011-07-12
申请号：US11972405
申请日：2008-01-10
IPC分类号： A61B5/05
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0535 , A61B5/1116 , A61B5/4869 , A61N1/36521 , A61N1/36535
摘要： This patent document discusses systems, devices, and methods for increasing a sensitivity or specificity of thoracic fluid detection in a subject and differentiating between pleural effusion and pulmonary edema. In one example, a thoracic impedance measurement circuit senses a thoracic impedance signal. In another example, a processor receives the thoracic impedance signal and determines whether such thoracic impedance signal is “significant.” A significant thoracic impedance signal indicates the presence of thoracic fluid and may be recognized by comparing the thoracic impedance signal (or variation thereof) to a thoracic impedance threshold. When a significant thoracic impedance signal is recognized, the processor is adapted to detect one or both of: a pleural effusion indication and a pulmonary edema indication using one or a combination of: physiologic information, patient symptom information, and posture information. In another example, the thoracic impedance threshold is adjusted using such physiologic, patient symptom, or posture information.
摘要翻译： 该专利文献讨论了用于增加受试者胸部液体检测的敏感性或特异性并区分胸腔积液和肺水肿的系统，装置和方法。 在一个示例中，胸部阻抗测量电路感测胸部阻抗信号。 在另一示例中，处理器接收胸部阻抗信号并确定这种胸部阻抗信号是否“显着”。显着的胸部阻抗信号表示胸腔存在，并且可以通过将胸部阻抗信号（或其变化）与 胸阻抗阈值。 当识别出显着的胸部阻抗信号时，处理器适合于使用生理信息，患者症状信息和姿势信息中的一个或组合来检测胸腔积液指示和肺水肿指示之一或两者。 在另一个例子中，使用这种生理，患者症状或姿势信息来调整胸阻抗阈值。
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8.发明申请公开(公告)号：US20110144526A1
公开(公告)日：2011-06-16
申请号：US13033081
申请日：2011-02-23
IPC分类号： A61B5/053
CPC分类号： A61B5/0537 , A61B5/0002 , A61B5/0538 , A61B5/4869 , A61B5/4878
摘要： This patent document discusses, among other things, systems, devices, and methods for enhancing detection of pulmonary edema using, in addition to thoracic impedance, one or a combination of: physiologic information about a subject, at least one statistical parameter, a user-programmable detection level, at least one parameter associated with a previous pulmonary edema event, and patient symptom information about the subject. In one example, a (base) thoracic impedance threshold is modified to an adjusted thoracic impedance threshold. The adjusted thoracic impedance threshold provides an increased sensitivity of pulmonary edema detection as compared to the base thoracic impedance threshold. In another example, an alert is provided to a subject, a caregiver, or other user based on a pulmonary edema indication determined by the present systems, devices, and methods. In a further example, a therapy (provided to the subject) is adjusted or initiated in response to the pulmonary edema indication.
摘要翻译： 该专利文献尤其涉及用于增强肺水肿检测的系统，装置和方法，除胸部阻抗之外，还包括以下之一或组合：关于受试者的生理信息，至少一个统计参数， 可编程检测水平，与先前的肺水肿事件相关联的至少一个参数，以及关于受试者的患者症状信息。 在一个示例中，（基底）胸部阻抗阈值被修改为经调整的胸部阻抗阈值。 与基础胸廓阻抗阈值相比，经调整的胸廓阻抗阈值提供了肺水肿检测的灵敏度增加。 在另一示例中，基于由本系统，设备和方法确定的肺水肿指示，向受检者，照顾者或其他用户提供警报。 在另一个实例中，响应于肺水肿指示调整或启动治疗（提供给受试者）。
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9.发明授权System and method for determining pulmonary performance from transthoracic impedance measures 有权用于确定经胸阻抗措施的肺功能的系统和方法公开(公告)号：US08795189B2
公开(公告)日：2014-08-05
申请号：US12029422
申请日：2008-02-11
申请人： Quan Ni , Jesse W. Hartley , Kent Lee , Jeffrey E. Stahmann
发明人： Quan Ni , Jesse W. Hartley , Kent Lee , Jeffrey E. Stahmann
IPC分类号： A61B5/08
CPC分类号： A61B5/0809 , A61B5/0002 , A61B5/0535 , A61N1/36521 , G06F19/3418
摘要： A system and method for determining pulmonary performance from transthoracic impedance measures is provided. Transthoracic impedance measures collected by an implantable medical device are correlated to pulmonary functional measures. The pulmonary functional measures are grouped by respiratory pattern. Pulmonary performance is evaluated. Differences are determined by comparing the pulmonary functional measures for each respiratory pattern to the pulmonary functional measures for at least one previous respiratory pattern. A trend is identified from the differences. An alert is generated upon sufficient deviation of the trend from a threshold criteria.
摘要翻译： 提供了一种通过经胸阻抗测量来确定肺功能的系统和方法。 由可植入医疗器械收集的经胸阻抗测量与肺功能测量相关。 肺功能测量按呼吸模式分组。 评估肺功能。 通过将每个呼吸模式的肺功能测量与至少一个之前的呼吸模式的肺功能测量进行比较来确定差异。 从差异中确定出一个趋势。 在趋势与阈值标准的充分偏差之后产生警报。
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10.发明授权Minimizing hemodynamic compromise during post-MI remodeling control pacing 有权在MI后重建控制起搏中最大限度地减少血液动力学损害公开(公告)号：US08731666B2
公开(公告)日：2014-05-20
申请号：US12819688
申请日：2010-06-21
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A method and device for delivering pre-excitation pacing to prevent or reduce cardiac remodeling following a myocardial infarction is described. The pre-excitation pacing is modulated in accordance with an assessment of cardiac function in order to balance the beneficial effects of stress reduction with hemodynamic compromise.
摘要翻译： 描述了用于递送预激发起搏以预防或减少心肌梗塞后的心脏重塑的方法和装置。 根据心脏功能的评估调节预激励起搏，以平衡应力减少与血液动力学妥协的有益效果。
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