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1.发明授权Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof 失效含有凝血酶和微原纤维纳米胶原的组合物及其制备和使用方法
公开(公告)号：US6096309A
公开(公告)日：2000-08-01
申请号：US99126
申请日：1998-06-17
CPC分类号： A61L24/106 , A61L24/043 , A61L24/102 , A61L2400/04
摘要： The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred embodiment of the present invention, the compositions are used in a kit comprising two different components, one of which is autologous patient's plasma as the source of fibrinogen, and the other of which is the thrombin-containing composition which also contains microfibrillar collagen having an average diameter of about 3-30 nanometers.
摘要翻译： 本发明涉及含凝血酶的止血组合物，其制备和用途。 具体地说，本发明涉及在水性介质中包含稳定的凝血酶和微原纤维胶原的止血组合物。 在本发明的优选实施方案中，组合物用于包含两种不同组分的试剂盒中，其中一种是自体患者的血浆作为纤维蛋白原的来源，另一种是含有含有微原纤维胶原蛋白的凝血酶组合物 平均直径约为3-30纳米。
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2.发明授权Compositions containing thrombin and microfibrillar collagen and methods for preparation and use thereof 有权含有凝血酶和微原纤维胶原的组合物及其制备和使用方法公开(公告)号：US06280727B1
公开(公告)日：2001-08-28
申请号：US09436903
申请日：1999-11-09
IPC分类号： A61K3800
CPC分类号： A61L24/106 , A61L24/043 , A61L24/102 , A61L2400/04 , C08L89/06
摘要： The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred embodiment of the present invention, the compositions are used in a kit comprising two different components, one of which is autologous patient's plasma as the source of fibrinogen, and the other of which is the thrombin-containing composition which also contains microfibrillar collagen.
摘要翻译： 本发明涉及含凝血酶的止血组合物，其制备和用途。 具体地说，本发明涉及在水性介质中包含稳定的凝血酶和微原纤维胶原的止血组合物。 在本发明的优选实施方案中，组合物用于包含两种不同组分的试剂盒中，其中一种是自体患者的血浆作为纤维蛋白原的来源，另一种是含有含有微原纤维胶原蛋白的凝血酶组合物 。
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公开(公告)号：US5290552A
公开(公告)日：1994-03-01
申请号：US855921
申请日：1992-03-23
申请人： David H. Sierra , Edward E. Luck , Dennis M. Brown
发明人： David H. Sierra , Edward E. Luck , Dennis M. Brown
IPC分类号： A61L24/00 , A61L24/10 , A61K35/16 , A61K37/547
CPC分类号： A61L24/102 , A61L24/0005 , A61L24/0084 , Y10S514/801
摘要： The present invention provides a surgical adhesive comprising, in an aqueous composition, fibrinogen, FXIII, collagen, thrombin, Ca.sup.2+ and optionally, an antifibrinolytic agent. The present adhesive may be formed from the patient's plasma without the use of any added reagents for concentration or isolation of the fibrinogen. Conveniently, the adhesive is formulated as a two-part composition which is mixed together just prior to use.
摘要翻译： 本发明提供一种手术粘合剂，其在水性组合物中包含纤维蛋白原，FXIII，胶原，凝血酶，Ca 2+和任选的抗纤维蛋白溶解剂。 本发明的粘合剂可以由患者的血浆形成，而不使用用于浓缩或分离纤维蛋白原的任何添加的试剂。 方便地，粘合剂被配制为在使用之前混合在一起的两部分组合物。
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公开(公告)号：US06277394B1
公开(公告)日：2001-08-21
申请号：US09596183
申请日：2000-06-16
申请人： David H. Sierra
发明人： David H. Sierra
IPC分类号： A61F200
CPC分类号： A61L27/56 , A61L27/225 , A61L27/26 , C08L89/00
摘要： The current invention is a biomedical implant comprising a biomedical matrix material and a biodegradable porosifying agent. As the porosifying agent degrades in situ, an implant with an inter-connecting network is formed. The resultant mechanically stable implant allows for tissue and fluid influx into the matrix. The invention is also directed to a method for repair of mammalian tissue using the above-described implant.
摘要翻译： 本发明是一种生物医学植入物，其包含生物医学基质材料和可生物降解的开孔剂。 当孔化剂原位降解时，形成具有相互连接网络的植入物。 所得到的机械稳定的植入物允许组织和流体流入基质。 本发明还涉及使用上述植入物修复哺乳动物组织的方法。
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公开(公告)号：US6110484A
公开(公告)日：2000-08-29
申请号：US199139
申请日：1998-11-24
申请人： David H. Sierra
发明人： David H. Sierra
CPC分类号： A61L27/56 , A61L27/225 , A61L27/26
摘要： The current invention is a biomedical implant comprising a biomedical matrix material and a biodegradable porosifying agent. As the porosifying agent degrades in situ, an implant with an inter-connecting network is formed. The resultant mechanically stable implant allows for tissue and fluid influx into the matrix. The invention is also directed to a method for repair of mammalian tissue using the above-described implant.
摘要翻译： 本发明是一种生物医学植入物，其包含生物医学基质材料和可生物降解的开孔剂。 当孔化剂原位降解时，形成具有相互连接网络的植入物。 所得到的机械稳定的植入物允许组织和流体流入基质。 本发明还涉及使用上述植入物修复哺乳动物组织的方法。
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公开(公告)号：US5968018A
公开(公告)日：1999-10-19
申请号：US741233
申请日：1996-10-30
CPC分类号： B01D21/262 , B01D21/245 , B01F5/0608 , B01F5/0688 , B01L3/5021 , B01D2221/10
摘要： A fluid separation device and in-line orifice mixer system is disclosed. The fluid separation device utilizes a syringe, which is used for obtaining a fluid sample such as blood, in a centrifugation device, and further utilizes the syringe as a source of a separated fluid portion for storage and transfer for subsequent applications. The syringe containing the separated portion source and a second syringe containing a second source are connected to the in-line orifice mixer device. The mixer device comprises a plurality of orifice walls each providing an orifice non-aligned with adjacent orifices to homogeneously mix the plurality of components. The mixer device may further comprise an exit orifice wall with one or more orifices for discharge of the homogeneous mixture.
摘要翻译： 公开了一种流体分离装置和直列孔式混合器系统。 流体分离装置在离心装置中使用用于获得诸如血液的流体样本的注射器，并且进一步利用注射器作为分离的流体部分的源，用于存储和转移用于随后的应用。 包含分离部分源的注射器和包含第二源的第二注射器连接到直列孔口混合器装置。 混合器装置包括多个孔壁，每个孔壁提供与相邻孔口不对准的孔口以均匀地混合多个部件。 混合器装置还可包括具有一个或多个用于排出均匀混合物的孔的出口孔壁。
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