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    Aqueous collagen composition
    2.
    发明授权
    Aqueous collagen composition 失效
    水性胶原蛋白组合物

    公开(公告)号：US4140537A

    公开(公告)日：1979-02-20

    申请号：US744536

    申请日：1976-11-24

    申请人： Edward E. Luck ,  John R. Daniels

    发明人： Edward E. Luck ,  John R. Daniels

    IPC分类号： A61F2/00 ,  A61K9/00 ,  A61L15/32 ,  A61L17/08 ,  A61L26/00 ,  A61L27/24 ,  A61L29/00 ,  B01D71/74 ,  C07K14/78 ,  C08L89/06 ,  D01D5/40 ,  D01F4/00

    CPC分类号： A61K9/0024 ,  A61L15/325 ,  A61L17/08 ,  A61L26/0033 ,  A61L27/24 ,  B01D71/74 ,  C08L89/06 ,  D01D5/40 ,  D01F4/00 ,  A61F2310/00365

    摘要： The naturally occurring collagen is modified by removal of certain terminal peptide chains, which are described as telopeptides. The modified collagen, so derived, is described as atelopeptide collagen. Native collagen is immunogenic, while atelopeptide collagen is nonimmunogenic or possessed of a negligibly low level of immunogenicity.The collagen in solution is then treated according to a specific regimen under conditions whereby the collagen slowly separates from solution while exposed to mild shear forces. This procedure results in the formation of a fibrous precipitate composed of regularly ordered fibers of collagen possessed of a ropelike structure. These resulting aggregates are referred to as native fibrous micropolymers (NFM). Once the regimen or procedure is completed, and the fiber mass has been formed, the fibrous micropolymers may be freed of salt, taken up in a different solution or modified. For example, cross-links may then be introduced to stabilize the fibers. The products find wide use as packing, membranes, fibers, bags, supports, integuments, and are especially suitable for biologic implantation or application.

    摘要翻译： 通过去除被描述为端肽的某些末端肽链修饰天然存在的胶原蛋白。 如此衍生的经修饰的胶原被描述为去糖肽胶原。 天然胶原蛋白是免疫原性的，而阿片肽胶原蛋白是非免疫原性的或具有可忽略的低水平的免疫原性。

    Non-antigenic collagen and articles of manufacture
    4.
    发明授权
    Non-antigenic collagen and articles of manufacture 失效
    非抗原性胶原蛋白和制品

    公开(公告)号：US4488911A

    公开(公告)日：1984-12-18

    申请号：US532572

    申请日：1983-09-15

    申请人： Edward E. Luck ,  John R. Daniels

    发明人： Edward E. Luck ,  John R. Daniels

    IPC分类号： A61F2/00 ,  A61L15/32 ,  A61L17/08 ,  A61L26/00 ,  A61L27/24 ,  C08L89/06 ,  D01F4/00 ,  C07G7/00

    CPC分类号： A61L15/325 ,  A61L17/08 ,  A61L26/0033 ,  A61L27/24 ,  C08L89/06 ,  D01F4/00 ,  A61F2310/00365 ,  Y10S530/84 ,  Y10S530/842

    摘要： Collagen, available from domestic animals, is freed of noncollagen proteins, glycosaminoglycans and lipids by enzymatic treatment with a proteolytic enzyme to yield a product which is soluble in dilute acidic aqueous solutions (collagen in solution--CIS). The naturally occurring collagen is modified by removal of certain terminal peptide chains, which are described as telopeptides. The modified collagen, so derived, is described as atelopeptide collagen. Native collagen is immunogenic, while atelopeptide collagen is nonimmunogenic or possessed of a negligibly low level of immunogenicity.The collagen in solution is then treated according to a specific regimen under conditions whereby the collagen slowly separates from solution while exposed to mild shear forces. This procedure results in the formation of a fibrous precipitate composed of regularly ordered fibers of collagen possessed of a rope-like structure. These resulting aggregates are referred to as native fibrous micropolymers (NFM). Once the regimen or procedure is completed, and the fiber mass has been formed, the fibrous micropolymers may be freed of salt, taken up in a different solution or modified. For example, cross-links may then be introduced to stabilize the fibers. The products find wide use as packing, membranes, fibers, bags, supports, integuments, and are especially suitable for biologic implantation or application.

    摘要翻译： 可从家畜获得的胶原蛋白通过用蛋白水解酶进行酶处理而不含非胶原蛋白质，糖胺聚糖和脂质，得到可溶于稀酸性水溶液（溶液-SC中的胶原）的产物。 通过去除被描述为端肽的某些末端肽链修饰天然存在的胶原蛋白。 如此衍生的经修饰的胶原被描述为去糖肽胶原。 天然胶原蛋白是免疫原性的，而阿片肽胶原蛋白是非免疫原性的或具有可忽略的低水平的免疫原性。 然后在条件下根据具体方案处理溶液中的胶原，由此在暴露于温和剪切力的同时胶原蛋白与溶液缓慢分离。 该过程导致由具有绳状结构的胶原的规则有序纤维构成的纤维沉淀物的形成。 这些所得的聚集体被称为天然纤维微聚合物（NFM）。 一旦完成了方案或程序，并且已经形成纤维质量，则纤维状微聚合物可以不含盐，被吸收在不同的溶液中或被改性。 例如，可以引入交联以稳定纤维。 该产品广泛用作包装，膜，纤维，袋，支撑物，珠子，特别适用于生物植入或应用。

    Non-antigenic collagen and articles of manufacture
    5.
    发明授权
    Non-antigenic collagen and articles of manufacture 失效
    非抗原性胶原蛋白和制品

    公开(公告)号：US4233360A

    公开(公告)日：1980-11-11

    申请号：US945723

    申请日：1978-09-25

    申请人： Edward E. Luck ,  John R. Daniels

    发明人： Edward E. Luck ,  John R. Daniels

    IPC分类号： A61F2/00 ,  A61L15/32 ,  A61L17/08 ,  A61L26/00 ,  A61L27/24 ,  C08L89/06 ,  B32B5/26 ,  A61L15/04

    CPC分类号： C08L89/06 ,  A61L15/325 ,  A61L17/08 ,  A61L26/0033 ,  A61L27/24 ,  A61F2310/00365 ,  Y10S128/08 ,  Y10S514/801 ,  Y10S623/915 ,  Y10T428/249986 ,  Y10T428/249988 ,  Y10T428/26 ,  Y10T428/31768

    摘要： Collagen, available from domestic animals, is freed of noncollagen proteins, glycosaminoglycans and lipids by enzymatic treatment with a proteolytic enzyme to yield a product which is soluble in dilute acidic aqueous solutions (collagen in solution--CIS). The naturally occurring collagen is modified by removal of certain terminal peptide chains, which are described as telopeptides. The modified collagen, so derived, is described as atelopeptide collagen. Native collagen is immunogenic, while atelopeptide collagen is nonimmunogenic or possessed of a negligibly low level of immunogenicity.The collagen in solution is then treated according to a specific regimen under conditions whereby the collagen slowly separates from solution while exposed to mild shear forces. This procedure results in the formation of a fibrous precipitate composed of regularly ordered fibers of collagen possessed of a ropelike structure. These resulting aggregates are referred to as native fibrous micropolymers (NFM). Once the regimen or procedure is completed, and the fiber mass has been formed, the fibrous micropolymers may be freed of salt, taken up in a different solution or modified. For example, cross-links may then be introduced to stabilize the fibers. The products find wide use as packing, membranes, fibers, bags, supports, integuments, and are especially suitable for biologic implantation or application.

    摘要翻译： 可从家畜获得的胶原蛋白通过用蛋白水解酶进行酶处理而不含非胶原蛋白质，糖胺聚糖和脂质，得到可溶于稀酸性水溶液（溶液-SC中的胶原）的产物。 通过去除被描述为端肽的某些末端肽链修饰天然存在的胶原蛋白。 如此衍生的经修饰的胶原被描述为去糖肽胶原。 天然胶原蛋白是免疫原性的，而阿片肽胶原蛋白是非免疫原性的或具有可忽略的低水平的免疫原性。 然后在条件下根据具体方案处理溶液中的胶原，由此在暴露于温和剪切力的同时胶原蛋白与溶液缓慢分离。 该过程导致由具有线状结构的胶原的规则排列的纤维组成的纤维沉淀物的形成。 这些所得的聚集体被称为天然纤维微聚合物（NFM）。 一旦完成了方案或程序，并且已经形成纤维质量，则纤维状微聚合物可以不含盐，被吸收在不同的溶液中或被改性。 例如，可以引入交联以稳定纤维。 该产品广泛用作包装，膜，纤维，袋，支撑物，珠子，特别适用于生物植入或应用。

    Microwave sterilization of dry protein
    6.
    发明授权
    Microwave sterilization of dry protein 失效
    干蛋白微波灭菌

    公开(公告)号：US4250139A

    公开(公告)日：1981-02-10

    申请号：US8652

    申请日：1979-02-01

    申请人： Edward E. Luck ,  John R. Daniels

    发明人： Edward E. Luck ,  John R. Daniels

    IPC分类号： A61L2/00 ,  A61L2/12 ,  C12N13/00 ,  A23L3/10 ,  A23L3/16

    CPC分类号： A61L2/0011 ,  A61L2/12

    摘要： Method for decontaminating proteinaceous host materials from microorganisms, while retaining chemical, physical and physiological properties of said host proteinaceous materials, said method comprising substantially dehydrating said host proteinaceous material, preferably by lyophilization, and subjecting said host material to a lethal dosage of microwave energy while said host material is maintained in substantially ambient conditions.

    摘要翻译： 在保留所述宿主蛋白质材料的化学，物理和生理特性的同时，从微生物中净化蛋白质主体材料的方法，所述方法优选通过冻干干燥基本脱水所述宿主蛋白质材料，并使所述宿主材料经受致死剂量的微波能量，同时 所述主体材料保持在基本环境条件下。

    Surgical adhesive material
    7.
    发明授权
    Surgical adhesive material 失效
    手术粘合剂材料

    公开(公告)号：US5290552A

    公开(公告)日：1994-03-01

    申请号：US855921

    申请日：1992-03-23

    申请人： David H. Sierra ,  Edward E. Luck ,  Dennis M. Brown

    发明人： David H. Sierra ,  Edward E. Luck ,  Dennis M. Brown

    IPC分类号： A61L24/00 ,  A61L24/10 ,  A61K35/16 ,  A61K37/547

    CPC分类号： A61L24/102 ,  A61L24/0005 ,  A61L24/0084 ,  Y10S514/801

    摘要： The present invention provides a surgical adhesive comprising, in an aqueous composition, fibrinogen, FXIII, collagen, thrombin, Ca.sup.2+ and optionally, an antifibrinolytic agent. The present adhesive may be formed from the patient's plasma without the use of any added reagents for concentration or isolation of the fibrinogen. Conveniently, the adhesive is formulated as a two-part composition which is mixed together just prior to use.

    摘要翻译： 本发明提供一种手术粘合剂，其在水性组合物中包含纤维蛋白原，FXIII，胶原，凝血酶，Ca 2+和任选的抗纤维蛋白溶解剂。 本发明的粘合剂可以由患者的血浆形成，而不使用用于浓缩或分离纤维蛋白原的任何添加的试剂。 方便地，粘合剂被配制为在使用之前混合在一起的两部分组合物。