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公开(公告)号：US09056150B2
公开(公告)日：2015-06-16
申请号：US11949990
申请日：2007-12-04
申请人： Jeffrey M. Gross , Steve Peckham , Jeffrey Scifert , Jeffrey Badura , Nelson Scarborough , Scott Vickers
发明人： Jeffrey M. Gross , Steve Peckham , Jeffrey Scifert , Jeffrey Badura , Nelson Scarborough , Scott Vickers
IPC分类号： A61F2/28 , A61K38/17 , A61K33/06 , A61P19/00 , A61L27/46 , A61L27/48 , A61L27/54 , A61K38/00
CPC分类号： A61L27/227 , A61K38/00 , A61L27/46 , A61L27/48 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2400/18 , A61L2420/02 , A61L2430/02
摘要： In certain described embodiments, implantable medical materials comprise a scaffolding material, a liquid organic binder, and entrapped calcium-containing particles. The medical materials can incorporate an osteoinductive factor such as a protein. The scaffolding material can bind the factor. In additional described embodiments, implantable medical materials include an osteoconductive scaffolding material, an incorporated osteoinductive factor, and a biodegradable barrier material effective to delay release of the factor from the scaffolding material. The scaffolding material can bind the factor. Also described a methods for preparing and implanting the described medical materials.
摘要翻译： 在某些描述的实施方案中，可植入医疗材料包括支架材料，液体有机粘合剂和包埋的含钙颗粒。 医学材料可以掺入骨诱导因子如蛋白质。 脚手架材料可以结合因子。 在另外描述的实施方案中，可植入医疗材料包括骨传导性支架材料，并入的骨诱导因子和有效延缓因子从脚手架材料释放的生物可降解阻挡材料。 脚手架材料可以结合因子。 还描述了用于制备和植入所描述的医疗材料的方法。
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公开(公告)号：US20090142385A1
公开(公告)日：2009-06-04
申请号：US11949990
申请日：2007-12-04
申请人： Jeffrey M. Gross , Steve Peckham , Jeffrey Scifert , Jeffrey Badura , Nelson Scarborough , Scott Vickers
发明人： Jeffrey M. Gross , Steve Peckham , Jeffrey Scifert , Jeffrey Badura , Nelson Scarborough , Scott Vickers
CPC分类号： A61L27/227 , A61K38/00 , A61L27/46 , A61L27/48 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2400/18 , A61L2420/02 , A61L2430/02
摘要： In certain described embodiments, implantable medical materials comprise a scaffolding material, a liquid organic binder, and entrapped calcium-containing particles. The medical materials can incorporate an osteoinductive factor such as a protein. The scaffolding material can bind the factor. In additional described embodiments, implantable medical materials include an osteoconductive scaffolding material, an incorporated osteoinductive factor, and a biodegradable barrier material effective to delay release of the factor from the scaffolding material. The scaffolding material can bind the factor. Also described a methods for preparing and implanting the described medical materials.
摘要翻译： 在某些描述的实施方案中，可植入医疗材料包括支架材料，液体有机粘合剂和包埋的含钙颗粒。 医学材料可以掺入骨诱导因子如蛋白质。 脚手架材料可以结合因子。 在另外描述的实施方案中，可植入医疗材料包括骨传导性支架材料，并入的骨诱导因子和有效延缓因子从脚手架材料释放的生物可降解阻挡材料。 脚手架材料可以结合因子。 还描述了用于制备和植入所描述的医疗材料的方法。
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公开(公告)号：US20070178130A1
公开(公告)日：2007-08-02
申请号：US11345605
申请日：2006-02-01
申请人： William McKay , Steve Peckham , Jeffrey Scifert
发明人： William McKay , Steve Peckham , Jeffrey Scifert
IPC分类号： A61K38/18
CPC分类号： A61L27/24 , A61K9/0024 , A61L24/0084 , A61L24/10 , A61L27/32 , A61L27/46 , A61L27/50 , A61L27/54 , A61L2300/414 , A61L2400/16 , A61L2430/02 , Y10S977/753 , Y10S977/776 , Y10S977/931
摘要： Described is an implantable medical material comprising a malleable, cohesive, shape-retaining putty including mineral particles, insoluble collagen fibers and soluble collagen. The medical material can be used in conjunction with biologically active factors such as osteogenic proteins to treat bone or other tissue defects in patients.
摘要翻译： 描述了一种植入式医疗材料，其包括可延展的，内聚的形状保持油灰，其包括矿物颗粒，不溶性胶原纤维和可溶性胶原蛋白。 医学材料可以与生物活性因子如成骨蛋白结合使用以治疗患者的骨或其他组织缺陷。
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公开(公告)号：US20110123705A1
公开(公告)日：2011-05-26
申请号：US13015923
申请日：2011-01-28
CPC分类号： A61L27/24 , A61K9/0024 , A61L24/0084 , A61L24/10 , A61L27/32 , A61L27/46 , A61L27/50 , A61L27/54 , A61L2300/414 , A61L2400/16 , A61L2430/02 , Y10S977/753 , Y10S977/776 , Y10S977/931
摘要： Described is an implantable medical material comprising a malleable, cohesive, shape-retaining putty including mineral particles, insoluble collagen fibers and soluble collagen. The medical material can be used in conjunction with biologically active factors such as osteogenic proteins to treat bone or other tissue defects in patients.
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公开(公告)号：US07939092B2
公开(公告)日：2011-05-10
申请号：US11345605
申请日：2006-02-01
CPC分类号： A61L27/24 , A61K9/0024 , A61L24/0084 , A61L24/10 , A61L27/32 , A61L27/46 , A61L27/50 , A61L27/54 , A61L2300/414 , A61L2400/16 , A61L2430/02 , Y10S977/753 , Y10S977/776 , Y10S977/931
摘要： Described is an implantable medical material comprising a malleable, cohesive, shape-retaining putty including mineral particles, insoluble collagen fibers and soluble collagen. The medical material can be used in conjunction with biologically active factors such as osteogenic proteins to treat bone or other tissue defects in patients.
摘要翻译： 描述了一种植入式医疗材料，其包括可延展的，内聚的形状保持油灰，其包括矿物颗粒，不溶性胶原纤维和可溶性胶原蛋白。 医学材料可以与生物活性因子如成骨蛋白结合使用以治疗患者的骨或其他组织缺陷。
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