公开(公告)号：US20100034742A1

公开(公告)日：2010-02-11

申请号：US12489242

申请日：2009-06-22

申请人： Jeffrey Schwartz ,  Christopher A. Traina ,  Thomas J. Dennes

发明人： Jeffrey Schwartz ,  Christopher A. Traina ,  Thomas J. Dennes

IPC分类号： A61K49/00 ,  B05D7/00 ,  B32B5/16 ,  C09K11/77 ,  A61B5/00 ,  A61N5/06

CPC分类号： A61K49/0017 ,  A61K49/0056 ,  A61K49/0065 ,  A61K49/0093 ,  G01N33/533 ,  G01N33/582 ,  G01N33/587 ,  Y10T428/2991

摘要： Nanoparticles are functionalized for use as bio-imaging probes using a novel, modular approach. Particle surface modification is based on a phosphonate monolayer platform on which was built a multi-segmented, multi-functional film: the first segment provided hydrolytic stability, the second aqueous suspendability, and the third, selectivity for cell attachment. In vitro imaging experiments visualized nanoparticle—cell surface binding. Peptide-derivatized nano-particles were not displaced from cells by soluble peptide. Methods for coating the host particles and use of rare earth ion-doped particles in imaging methods and photodynamic therapy methods are also disclosed.

摘要翻译： 使用新颖的模块化方法将纳米颗粒功能化用作生物成像探针。 颗粒表面改性是基于一种膦酸盐单层平台，其上建立了多段多功能膜：第一段提供了水解稳定性，第二水性悬浮性，第三段选择性为细胞附着。 体外成像实验可视化纳米颗粒细胞表面结合。 肽衍生的纳米颗粒不能通过可溶性肽从细胞中移位。 还公开了在成像方法和光动力学治疗方法中涂覆主体颗粒和使用稀土离子掺杂颗粒的方法。

公开(公告)号：US20090104474A1

公开(公告)日：2009-04-23

申请号：US12253462

申请日：2008-10-17

申请人： Jeffrey Schwartz ,  Thomas J. Dennes

发明人： Jeffrey Schwartz ,  Thomas J. Dennes

IPC分类号： B32B27/06 ,  B05D3/06 ,  B05D3/02 ,  B05D5/10

CPC分类号： A61L27/306 ,  A61L27/14 ,  A61L27/18 ,  C23C18/06 ,  C23C18/1216 ,  C23C18/122 ,  C23C18/1225 ,  C23C18/1233 ,  C23C18/1237 ,  C23C18/1295 ,  C23C18/1658 ,  C23C18/2066 ,  C23C18/2086 ,  C23C18/40 ,  Y10T428/24802 ,  Y10T428/31786 ,  Y10T428/31942

摘要： Polymer substrates including adhesion layers for activating the surface of the substrate are provided, thereby allowing the substrate to react with organic, inorganic, metallic and/or organometallic materials. The surface of the polymer substrate is coated with a metal oxide layer that is subjected to conditions adequate to form an oxide adhesion layer. Combining deposition techniques for formation of functionalized polymer surfaces with photolithographic techniques enables spatial control of RGD presentation at the polymer surfaces are achieved with sub-cellular resolution. Surface patterning enables control of cell adhesion location at the surface of the polymer and influences cell shape. Metallization of polymers as described herein provides a means to prepare metal-based electrical circuitry on a variety of flexible substrates.

摘要翻译： 提供了包括用于活化基材表面的粘合层的聚合物基材，从而使基材与有机，无机，金属和/或有机金属材料反应。 聚合物基材的表面涂覆有经受足以形成氧化物粘合层的条件的金属氧化物层。 结合用于用光刻技术形成官能化聚合物表面的沉积技术使得能够通过亚细胞分辨率实现聚合物表面处的RGD表现的空间控制。 表面图案化可以控制聚合物表面的细胞粘附位置并影响细胞形状。 本文所述的聚合物的金属化提供了在各种柔性基底上制备基于金属的电路的方法。