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公开(公告)号：US08343533B2
公开(公告)日：2013-01-01
申请号：US12887575
申请日：2010-09-22
申请人： Jen-Chi Chen , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Christopher E. Szymczak , Gregory E. Koll
发明人： Jen-Chi Chen , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Christopher E. Szymczak , Gregory E. Koll
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a process for making a lozenge product including the steps of forming a powder blend containing an amorphous carbohydrate polymer into the desired shape of the lozenge product and applying radiofrequency energy to the shape for a sufficient period of time to soften or melt said amorphous carbohydrate polymer to fuse the shape into said lozenge product.
摘要翻译： 本发明的特征在于制备锭剂的方法，包括以下步骤：将含有无定形碳水化合物聚合物的粉末混合物形成所需形状的锭剂，并将射频能量施加到形状足够长的时间以软化或熔化所述 无定形碳水化合物聚合物，以将形状熔合到所述锭剂中。
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公开(公告)号：US20110070170A1
公开(公告)日：2011-03-24
申请号：US12887582
申请日：2010-09-22
申请人： Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
发明人： Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a process for making a chewing gum product including the steps of forming a powder blend containing a gum base into the desired shape of the chewing gum product and applying radiofrequency energy to the shape for a sufficient period of time to soften the gum base to fuse the shape into the chewing gum product.
摘要翻译： 本发明的特征在于制备口香糖产品的方法，包括以下步骤：将含有胶基的粉末混合物形成所需形状的口香糖产品，并将射频能量施加到形状足够的时间以软化口香糖 将形状融合到口香糖产品中。
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公开(公告)号：US08784781B2
公开(公告)日：2014-07-22
申请号：US12887582
申请日：2010-09-22
申请人： Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
发明人： Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
IPC分类号： A61K9/68 , A23G4/00 , A23G4/20 , A61P25/34 , A61K9/20 , A61J3/06 , B30B15/34 , B30B11/02 , B30B11/10 , A61K9/00 , A61K9/28 , B29C35/08
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a process for making a chewing gum product including the steps of forming a powder blend containing a gum base into the desired shape of the chewing gum product and applying radiofrequency energy to the shape for a sufficient period of time to soften the gum base to fuse the shape into the chewing gum product.
摘要翻译： 本发明的特征在于制备口香糖产品的方法，包括以下步骤：将含有胶基的粉末混合物形成所需形状的口香糖产品，并将射频能量施加到形状足够的时间以软化口香糖 将形状融合到口香糖产品中。
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4.发明申请PROCESS FOR THE MANUFACTURE OF NICOTINE-COMPRISING CHEWING GUM AND NICOTINE-COMPRISING CHEWING GUM MANUFACTURED ACCORDING TO SAID PROCESS 审中-公开用于制造包含CHEWING GUM和NICOTINE包含根据SAI过程制造的CHEWING GUM的制造方法公开(公告)号：US20110070286A1
公开(公告)日：2011-03-24
申请号：US12887593
申请日：2010-09-22
申请人： Andreas Hugerth , Katarina Lindell , Fredrik Nicklasson , John Hedenstrom , Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
发明人： Andreas Hugerth , Katarina Lindell , Fredrik Nicklasson , John Hedenstrom , Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
CPC分类号： A61K9/0058 , A23G4/04 , A23G4/06 , A23G4/12 , A23P10/20
摘要： A process for making a nicotine-comprising chewing gum by (i) dispensing a powder portion from a gum-base-comprising powder, (ii) optionally shaping said powder portion into a powder aggregate, and (iii) applying sufficient electromagnetic energy (EM energy) to said powder portion or said powder aggregate to transform said powder portion or said powder aggregate into said chewing gum, whereby said EM energy is Radio Frequency (RF) energy, MicroWave (MW) energy, InfraRed (IR) energy or UltraViolet (UV) energy or combinations thereof. The invention also features a chewing gum made by such process. The chewing gum may comprise one or more deposits.
摘要翻译： 一种通过以下步骤制备含尼古丁的口香糖的方法：（i）从含胶基的粉末中分配粉末部分，（ii）任选将所述粉末部分成型为粉末聚集体，和（iii）施加足够的电磁能 能量）到所述粉末部分或所述粉末聚集体以将所述粉末部分或所述粉末聚集体转化成所述口香糖，由此所述EM能量是射频（RF）能量，微波（MW）能量，红外（IR）能量或紫外线 UV）能量或其组合。 本发明还具有通过这种方法制成的口香糖。 口香糖可以包含一种或多种沉积物。
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公开(公告)号：US20110071183A1
公开(公告)日：2011-03-24
申请号：US12887575
申请日：2010-09-22
申请人： Jen-Chi Chen , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Christopher E. Szymczak
发明人： Jen-Chi Chen , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Christopher E. Szymczak
IPC分类号： A61K31/4748 , A61K31/465 , A61K31/045 , A61K31/133 , A61K31/4545 , A61P25/34 , B29C43/52
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a process for making a lozenge product including the steps of forming a powder blend containing an amorphous carbohydrate polymer into the desired shape of the lozenge product and applying radiofrequency energy to the shape for a sufficient period of time to soften or melt said amorphous carbohydrate polymer to fuse the shape into said lozenge product.
摘要翻译： 本发明的特征在于制备锭剂的方法，包括以下步骤：将含有无定形碳水化合物聚合物的粉末混合物形成所需形状的锭剂，并将射频能量施加到形状足够长的时间以软化或熔化所述 无定形碳水化合物聚合物，以将形状熔合到所述锭剂中。
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6.发明授权公开(公告)号：US09610224B2
公开(公告)日：2017-04-04
申请号：US12887552
申请日：2010-09-22
申请人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
发明人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
IPC分类号： A61K31/138 , A61J3/10 , B29C43/08 , A61K9/00 , A61K9/68 , A61K9/20 , A61K9/28 , B30B11/02 , B30B11/10 , B30B15/34 , A61K31/167 , A61K31/192 , B29C35/08
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features the present invention features a process for making a tablet by compacting a powder blend in a die platen to form a tablet shape, wherein the powder blend includes a pharmaceutically active agent and a water-containing material, and applying energy to the tablet shape for a sufficient period of time to heat the water-containing material within the tablet shape above its dehydration temperature to form the tablet.
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7.发明授权Manufacture of tablet in a die utilizing radiofrequency energy and meltable binder 有权使用射频能量和可熔融粘合剂在模具中制造片剂公开(公告)号：US08871263B2
公开(公告)日：2014-10-28
申请号：US12887544
申请日：2010-09-22
申请人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
发明人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
IPC分类号： A61K9/20 , A61K9/14 , A61K31/44 , A61K47/00 , A61K9/28 , B30B11/10 , B30B11/02 , A61K9/68 , A61K9/00 , B30B15/34 , B29C35/08
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a process for making a tablet by (i) compacting a powder blend in a die to form a tablet shape, wherein the powder blend contains a pharmaceutically active agent and a meltable binder and (ii) applying radiofrequency energy to the tablet shape for a sufficient period of time to soften or melt the binder within said tablet shape to form the tablet.
摘要翻译： 本发明的特征在于制备片剂的方法，该方法是通过（i）压制模头中的粉末共混物以形成片剂形式，其中粉末混合物含有药物活性剂和可熔融粘合剂，和（ii）向片剂施加射频能量 形成足够的时间以软化或熔化所述片剂形状中的粘合剂以形成片剂。
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8.发明申请MANUFACTURE OF TABLET IN A DIE UTILIZING POWDER BLEND CONTAINING WATER-CONTAINING MATERIAL 有权在含有含水材料的粉末混合物中使用的片剂的制造公开(公告)号：US20110071185A1
公开(公告)日：2011-03-24
申请号：US12887552
申请日：2010-09-22
申请人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
发明人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
IPC分类号： B30B11/00 , B29C43/32 , B29C43/02 , A61K31/167 , A61K31/438 , A61P29/00 , A61P11/00 , A61P11/02
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features the present invention features a process for making a tablet by compacting a powder blend in a die platen to form a tablet shape, wherein the powder blend includes a pharmaceutically active agent and a water-containing material, and applying energy to the tablet shape for a sufficient period of time to heat the water-containing material within the tablet shape above its dehydration temperature to form the tablet.
摘要翻译： 本发明的特征在于本发明的特征在于一种制备片剂的方法，其通过在模板中压制粉末共混物形成片剂形式，其中粉末混合物包括药物活性剂和含水材料，并向 片剂形状足够的时间以将片剂形式的含水材料加热到其脱水温度以上以形成片剂。
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公开(公告)号：US20110070301A1
公开(公告)日：2011-03-24
申请号：US12887564
申请日：2010-09-22
申请人： Joseph R. Luber , Harry S. Sowden , Frank J. Bunick , Leo B. Kriksunov , David W. Wynn , Christopher E. Szymczak
发明人： Joseph R. Luber , Harry S. Sowden , Frank J. Bunick , Leo B. Kriksunov , David W. Wynn , Christopher E. Szymczak
IPC分类号： A61K9/20 , A61K31/167 , A61K31/192 , A61P29/00 , G21G5/00
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a tablet including one or more pharmaceutically active agent(s), one or more thickeners, and one or more binder(s), wherein the tablet includes at least 200 mg of the pharmaceutically active agent(s) and the tablet has been fused with the binder(s) such that the tablet (i) has a water permeation time of less than 60 seconds and (ii) has an in vitro disintegration time of greater than 60 seconds.
摘要翻译： 本发明的特征在于包含一种或多种药物活性剂，一种或多种增稠剂和一种或多种粘合剂的片剂，其中片剂包含至少200mg的药物活性剂和片剂 已经与粘合剂熔合，使得片剂（i）具有小于60秒的水渗透时间，和（ii）具有大于60秒的体外崩解时间。
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10.发明授权公开(公告)号：US08858210B2
公开(公告)日：2014-10-14
申请号：US13052219
申请日：2011-03-21
申请人： Christopher E. Szymczak , Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov
发明人： Christopher E. Szymczak , Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov
IPC分类号： B30B11/10 , A61K9/14 , A61K9/20 , A61K9/00 , A61K31/167 , A61K31/138 , B30B11/08 , A61K31/4545 , B30B11/02 , B30B15/34 , B29C43/00 , B29C43/36
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/145 , A61K9/146 , A61K9/2018 , A61K9/2031 , A61K9/2036 , A61K9/205 , A61K9/2086 , A61K9/2095 , A61K31/138 , A61K31/167 , A61K31/4545 , B29C43/006 , B29C43/146 , B29C2043/3628 , B30B11/027 , B30B11/085 , B30B11/10 , B30B15/34
摘要： The present invention features the present invention features a tablet including at least one pharmaceutically active ingredient, wherein the shape of said tablet includes at least one major face wherein: (i) the peak penetration resistance at the perimeter of said major face of the tablet is at least about 10% greater than the peak penetration resistance at the center of said major face; and (ii) the tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds, and a machine and method for manufacture of such tablet.
摘要翻译： 本发明的特征在于本发明的特征在于包含至少一种药物活性成分的片剂，其中所述片剂的形状包括至少一个主要面，其中：（i）片剂的所述主要面的周边的耐峰值渗透性为 比所述主面的中心处的峰值穿透阻力大至少约10％ 和（ii）片剂在短时间内放置在舌头上时在口中崩解，以及制造这种片剂的机器和方法。
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