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公开(公告)号：US08784781B2
公开(公告)日：2014-07-22
申请号：US12887582
申请日：2010-09-22
申请人： Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
发明人： Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
IPC分类号： A61K9/68 , A23G4/00 , A23G4/20 , A61P25/34 , A61K9/20 , A61J3/06 , B30B15/34 , B30B11/02 , B30B11/10 , A61K9/00 , A61K9/28 , B29C35/08
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a process for making a chewing gum product including the steps of forming a powder blend containing a gum base into the desired shape of the chewing gum product and applying radiofrequency energy to the shape for a sufficient period of time to soften the gum base to fuse the shape into the chewing gum product.
摘要翻译： 本发明的特征在于制备口香糖产品的方法，包括以下步骤：将含有胶基的粉末混合物形成所需形状的口香糖产品，并将射频能量施加到形状足够的时间以软化口香糖 将形状融合到口香糖产品中。
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2.发明申请PROCESS FOR THE MANUFACTURE OF NICOTINE-COMPRISING CHEWING GUM AND NICOTINE-COMPRISING CHEWING GUM MANUFACTURED ACCORDING TO SAID PROCESS 审中-公开用于制造包含CHEWING GUM和NICOTINE包含根据SAI过程制造的CHEWING GUM的制造方法公开(公告)号：US20110070286A1
公开(公告)日：2011-03-24
申请号：US12887593
申请日：2010-09-22
申请人： Andreas Hugerth , Katarina Lindell , Fredrik Nicklasson , John Hedenstrom , Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
发明人： Andreas Hugerth , Katarina Lindell , Fredrik Nicklasson , John Hedenstrom , Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
CPC分类号： A61K9/0058 , A23G4/04 , A23G4/06 , A23G4/12 , A23P10/20
摘要： A process for making a nicotine-comprising chewing gum by (i) dispensing a powder portion from a gum-base-comprising powder, (ii) optionally shaping said powder portion into a powder aggregate, and (iii) applying sufficient electromagnetic energy (EM energy) to said powder portion or said powder aggregate to transform said powder portion or said powder aggregate into said chewing gum, whereby said EM energy is Radio Frequency (RF) energy, MicroWave (MW) energy, InfraRed (IR) energy or UltraViolet (UV) energy or combinations thereof. The invention also features a chewing gum made by such process. The chewing gum may comprise one or more deposits.
摘要翻译： 一种通过以下步骤制备含尼古丁的口香糖的方法：（i）从含胶基的粉末中分配粉末部分，（ii）任选将所述粉末部分成型为粉末聚集体，和（iii）施加足够的电磁能 能量）到所述粉末部分或所述粉末聚集体以将所述粉末部分或所述粉末聚集体转化成所述口香糖，由此所述EM能量是射频（RF）能量，微波（MW）能量，红外（IR）能量或紫外线 UV）能量或其组合。 本发明还具有通过这种方法制成的口香糖。 口香糖可以包含一种或多种沉积物。
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公开(公告)号：US08343533B2
公开(公告)日：2013-01-01
申请号：US12887575
申请日：2010-09-22
申请人： Jen-Chi Chen , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Christopher E. Szymczak , Gregory E. Koll
发明人： Jen-Chi Chen , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Christopher E. Szymczak , Gregory E. Koll
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a process for making a lozenge product including the steps of forming a powder blend containing an amorphous carbohydrate polymer into the desired shape of the lozenge product and applying radiofrequency energy to the shape for a sufficient period of time to soften or melt said amorphous carbohydrate polymer to fuse the shape into said lozenge product.
摘要翻译： 本发明的特征在于制备锭剂的方法，包括以下步骤：将含有无定形碳水化合物聚合物的粉末混合物形成所需形状的锭剂，并将射频能量施加到形状足够长的时间以软化或熔化所述 无定形碳水化合物聚合物，以将形状熔合到所述锭剂中。
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公开(公告)号：US20110070170A1
公开(公告)日：2011-03-24
申请号：US12887582
申请日：2010-09-22
申请人： Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
发明人： Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a process for making a chewing gum product including the steps of forming a powder blend containing a gum base into the desired shape of the chewing gum product and applying radiofrequency energy to the shape for a sufficient period of time to soften the gum base to fuse the shape into the chewing gum product.
摘要翻译： 本发明的特征在于制备口香糖产品的方法，包括以下步骤：将含有胶基的粉末混合物形成所需形状的口香糖产品，并将射频能量施加到形状足够的时间以软化口香糖 将形状融合到口香糖产品中。
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公开(公告)号：US20110071183A1
公开(公告)日：2011-03-24
申请号：US12887575
申请日：2010-09-22
申请人： Jen-Chi Chen , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Christopher E. Szymczak
发明人： Jen-Chi Chen , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Christopher E. Szymczak
IPC分类号： A61K31/4748 , A61K31/465 , A61K31/045 , A61K31/133 , A61K31/4545 , A61P25/34 , B29C43/52
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a process for making a lozenge product including the steps of forming a powder blend containing an amorphous carbohydrate polymer into the desired shape of the lozenge product and applying radiofrequency energy to the shape for a sufficient period of time to soften or melt said amorphous carbohydrate polymer to fuse the shape into said lozenge product.
摘要翻译： 本发明的特征在于制备锭剂的方法，包括以下步骤：将含有无定形碳水化合物聚合物的粉末混合物形成所需形状的锭剂，并将射频能量施加到形状足够长的时间以软化或熔化所述 无定形碳水化合物聚合物，以将形状熔合到所述锭剂中。
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6.发明授权公开(公告)号：US08858210B2
公开(公告)日：2014-10-14
申请号：US13052219
申请日：2011-03-21
申请人： Christopher E. Szymczak , Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov
发明人： Christopher E. Szymczak , Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov
IPC分类号： B30B11/10 , A61K9/14 , A61K9/20 , A61K9/00 , A61K31/167 , A61K31/138 , B30B11/08 , A61K31/4545 , B30B11/02 , B30B15/34 , B29C43/00 , B29C43/36
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/145 , A61K9/146 , A61K9/2018 , A61K9/2031 , A61K9/2036 , A61K9/205 , A61K9/2086 , A61K9/2095 , A61K31/138 , A61K31/167 , A61K31/4545 , B29C43/006 , B29C43/146 , B29C2043/3628 , B30B11/027 , B30B11/085 , B30B11/10 , B30B15/34
摘要： The present invention features the present invention features a tablet including at least one pharmaceutically active ingredient, wherein the shape of said tablet includes at least one major face wherein: (i) the peak penetration resistance at the perimeter of said major face of the tablet is at least about 10% greater than the peak penetration resistance at the center of said major face; and (ii) the tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds, and a machine and method for manufacture of such tablet.
摘要翻译： 本发明的特征在于本发明的特征在于包含至少一种药物活性成分的片剂，其中所述片剂的形状包括至少一个主要面，其中：（i）片剂的所述主要面的周边的耐峰值渗透性为 比所述主面的中心处的峰值穿透阻力大至少约10％ 和（ii）片剂在短时间内放置在舌头上时在口中崩解，以及制造这种片剂的机器和方法。
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7.发明申请MANUFACTURE OF TABLET IN A DIE UTILIZING POWDER BLEND CONTAINING WATER-CONTAINING MATERIAL 审中-公开在含有含水材料的粉末混合物中使用的片剂的制造公开(公告)号：US20120022170A1
公开(公告)日：2012-01-26
申请号：US13246884
申请日：2011-09-28
申请人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
发明人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features the present invention features a process for making a tablet by compacting a powder blend in a die platen to form a tablet shape, wherein the powder blend includes a pharmaceutically active agent and a water-containing material, and applying energy to the tablet shape for a sufficient period of time to heat the water-containing material within the tablet shape above its dehydration temperature to form the tablet.
摘要翻译： 本发明的特征在于本发明的特征在于一种制备片剂的方法，其通过在模板中压制粉末共混物形成片剂形式，其中粉末混合物包括药物活性剂和含水材料，并向 片剂形状足够的时间以将片剂形式的含水材料加热到其脱水温度以上以形成片剂。
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8.发明授权公开(公告)号：US08807979B2
公开(公告)日：2014-08-19
申请号：US12887569
申请日：2010-09-22
申请人： Harry S. Sowden , Frank J. Bunick , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
发明人： Harry S. Sowden , Frank J. Bunick , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
IPC分类号： B29C35/12 , B29C43/04 , B29C43/06 , B29C43/08 , A61K9/20 , B30B11/02 , B30B15/34 , A61J3/06 , A61K9/28 , A61K9/00 , A61K9/68 , B30B11/10 , B29C35/08
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features the present invention features a machine for the production of a solid dosage form including: (a) a die platen having one or more forming cavities each having an inner wall, a first opening at the surface of one side of the die platen, and a second opening at the surface on the opposite side of the die platen; (b) one or more first forming tools each adapted to move into one of the forming cavities through the first opening of the forming cavity; (c) one or more second forming tools each adapted to move adjacent to one of the second openings or into one of the forming cavities through the second opening of the forming cavity; (d) at least one first RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; and (e) at least one second RF electrode operably associated with the one or more first forming tools.
摘要翻译： 本发明的特征在于本发明的特征在于一种用于生产固体剂型的机器，所述机器包括：（a）具有一个或多个成形腔的模板，所述成形腔各自具有内壁，所述模具的一侧的表面处的第一开口 压板和在模板的相对侧的表面处的第二开口; （b）一个或多个第一成形工具，每个适于通过成形腔的第一开口移动到一个成形腔中; （c）一个或多个第二成形工具，每个第二成形工具各自适于通过成形腔的第二开口移动到第二开口中的一个或成形空腔中的一个; （d）至少一个第一RF电极，其与所述一个或多个第一成形工具，所述一个或多个第二成形工具或所述一个或多个成形腔的内壁可操作地相关联; 和（e）至少一个与所述一个或多个第一成形工具可操作地相关联的第二RF电极。
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9.发明申请MANUFACTURE OF TABLET IN A DIE UTILIZING RADIOFREQUENCY ENERGY AND MELTABLE BINDER 有权在使用无线电能量和可熔性粘合剂的模具中制作片剂公开(公告)号：US20110071184A1
公开(公告)日：2011-03-24
申请号：US12887544
申请日：2010-09-22
申请人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
发明人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
IPC分类号： A61K31/4545 , A61K31/138 , A61K31/047 , A61K31/167 , A61P37/00 , A61P1/00 , A61P23/00 , A61P3/00 , A61P29/00 , B29C43/52
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features a process for making a tablet by (i) compacting a powder blend in a die to form a tablet shape, wherein the powder blend contains a pharmaceutically active agent and a meltable binder and (ii) applying radiofrequency energy to the tablet shape for a sufficient period of time to soften or melt the binder within said tablet shape to form the tablet.
摘要翻译： 本发明的特征在于制备片剂的方法，该方法是通过（i）压制模头中的粉末共混物以形成片剂形式，其中粉末混合物含有药物活性剂和可熔融粘合剂，和（ii）向片剂施加射频能量 形成足够的时间以软化或熔化所述片剂形状中的粘合剂以形成片剂。
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10.发明授权公开(公告)号：US09610224B2
公开(公告)日：2017-04-04
申请号：US12887552
申请日：2010-09-22
申请人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
发明人： Frank J. Bunick , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Christopher E. Szymczak
IPC分类号： A61K31/138 , A61J3/10 , B29C43/08 , A61K9/00 , A61K9/68 , A61K9/20 , A61K9/28 , B30B11/02 , B30B11/10 , B30B15/34 , A61K31/167 , A61K31/192 , B29C35/08
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/0058 , A61K9/2031 , A61K9/205 , A61K9/2068 , A61K9/2086 , A61K9/2095 , A61K9/2853 , A61K9/288 , A61K31/167 , A61K31/192 , B29C43/08 , B29C2035/0861 , B30B11/022 , B30B11/027 , B30B11/10 , B30B15/34
摘要： The present invention features the present invention features a process for making a tablet by compacting a powder blend in a die platen to form a tablet shape, wherein the powder blend includes a pharmaceutically active agent and a water-containing material, and applying energy to the tablet shape for a sufficient period of time to heat the water-containing material within the tablet shape above its dehydration temperature to form the tablet.
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