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1.发明申请Protein having prolyl oligopeptidase activity, nucleic acid encoding same and method for producing and using same 有权具有脯氨酰寡肽酶活性的蛋白质，编码相同的核酸及其制备和使用方法公开(公告)号：US20090269327A1
公开(公告)日：2009-10-29
申请号：US12081984
申请日：2008-04-24
申请人： Jen-Tao Chen , Mei-Li Chao , Chiou-Yen Wen , Wen-Shen Chu
发明人： Jen-Tao Chen , Mei-Li Chao , Chiou-Yen Wen , Wen-Shen Chu
CPC分类号： C12Y304/21026 , A61K38/00 , C12N9/6408
摘要： Proteins isolated from Coprinus clostophyllus having prolyl oligopeptidase activity, nucleic acids encoding the protein and methods for producing and using the protein, wherein SEQ ID NO:5, SEQ ID NO:6 and SEQ ID NO:10 must be contained therein to at least 60% similarity. The proteins and nucleic acids have improved heat stability and perform more favorably in vivo having optimum activity conditions around 40 degrees centigrade and around pH 7, and can therefore be used in medicaments for the treatment of celiac disease caused by proline abundant gluten or other applications.
摘要翻译： 分离自具有脯氨酰寡肽酶活性的鬼伞属的蛋白质，编码蛋白质的核酸及其生产和使用蛋白质的方法，其中必须含有SEQ ID NO：5，SEQ ID NO：6和SEQ ID NO：10至少至少60 ％相似度。 蛋白质和核酸具有改善的热稳定性，并且在体内具有最佳活性条件在约40摄氏度和约pH 7左右的体内更有利，因此可用于治疗由脯氨酸丰富的面筋或其他应用引起的乳糜泻的药物。
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2.发明申请Protein Having Prolyl Oligopeptidase Activity, Nucleic Acid Encoding Same and Method for Producing and Using Same 有权具有脯氨酰寡肽酶活性的蛋白质，编码相同的核酸及其生产和使用方法公开(公告)号：US20100086558A1
公开(公告)日：2010-04-08
申请号：US12581304
申请日：2009-10-19
申请人： Jen-Tao Chen , Mei-Li Chao , Wen-Shen Chu , Chiou-Yen Wen
发明人： Jen-Tao Chen , Mei-Li Chao , Wen-Shen Chu , Chiou-Yen Wen
IPC分类号： A61K39/395 , C12N9/48 , A61K38/48 , A61P25/28
CPC分类号： C12Y304/21026 , A61K38/00 , C12N9/6408
摘要： Proteins isolated from Coprinus clastophyllus having prolyl oligopeptidase activity, nucleic acids encoding the protein and methods for producing and using the protein, wherein SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:9 and SEQ ID NO:10 must be contained therein to at least 60% similarity. The proteins and nucleic acids have improved heat stability and perform more favorably in vivo having optimum activity conditions around 40 degrees centigrade and around pH 7, and can therefore be used in medicaments for the treatment of celiac disease caused by proline abundant gluten or other applications.
摘要翻译： 从具有脯氨酰寡肽酶活性的鬼马属分离得到的蛋白质，编码蛋白质的核酸及其制备和使用蛋白质的方法，其中SEQ ID NO：5，SEQ ID NO：6，SEQ ID NO：9和SEQ ID NO：10必须为 含有至少60％的相似性。 蛋白质和核酸具有改善的热稳定性，并且在体内具有最佳活性条件在约40摄氏度和约pH 7左右的体内更有利，因此可用于治疗由脯氨酸丰富的面筋或其他应用引起的乳糜泻的药物。
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3.发明授权Protein having prolyl oligopeptidase activity, nucleic acid encoding same and method for producing and using same 有权具有脯氨酰寡肽酶活性的蛋白质，编码相同的核酸及其制备和使用方法公开(公告)号：US07960162B2
公开(公告)日：2011-06-14
申请号：US12581304
申请日：2009-10-19
申请人： Jen-Tao Chen , Mei-Li Chao , Wen-Shen Chu , Chiou-Yen Wen
发明人： Jen-Tao Chen , Mei-Li Chao , Wen-Shen Chu , Chiou-Yen Wen
IPC分类号： C12N9/48
CPC分类号： C12Y304/21026 , A61K38/00 , C12N9/6408
摘要： Proteins isolated from Coprinus clastophyllus having prolyl oligopeptidase activity, nucleic acids encoding the protein and methods for producing and using the protein, wherein SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:9 and SEQ ID NO:10 must be contained therein to at least 60% similarity. The proteins and nucleic acids have improved heat stability and perform more favorably in vivo having optimum activity conditions around 40 degrees centigrade and around pH 7, and can therefore be used in medicaments for the treatment of celiac disease caused by proline abundant gluten or other applications.
摘要翻译： 从具有脯氨酰寡肽酶活性的鬼马属分离得到的蛋白质，编码蛋白质的核酸及其制备和使用蛋白质的方法，其中SEQ ID NO：5，SEQ ID NO：6，SEQ ID NO：9和SEQ ID NO：10必须为 含有至少60％的相似性。 蛋白质和核酸具有改善的热稳定性，并且在体内具有最佳活性条件在约40摄氏度和约pH 7左右的体内更有利，因此可用于治疗由脯氨酸丰富的面筋或其他应用引起的乳糜泻的药物。
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4.发明授权Protein having prolyl oligopeptidase activity, and composition containing the same 有权具有脯氨酰寡肽酶活性的蛋白质和含有它们的组合物公开(公告)号：US07741094B2
公开(公告)日：2010-06-22
申请号：US12081984
申请日：2008-04-24
申请人： Jen-Tao Chen , Mei-Li Chao , Chiou-Yen Wen , Wen-Shen Chu
发明人： Jen-Tao Chen , Mei-Li Chao , Chiou-Yen Wen , Wen-Shen Chu
IPC分类号： C12N9/48
CPC分类号： C12Y304/21026 , A61K38/00 , C12N9/6408
摘要： A protein of amino acid sequence SEQ ID NO:6 isolated from Coprinus clastophyllus. The protein is stable at 30 to 37 degrees centigrade and has an optimal prolyl oligopeptidase activity at about 45 degree centigrade and at about pH 7. The present invention also relates to a medicament comprising such protein for treating celiac disease caused by proline abundant gluten.
摘要翻译： 从鬼伞鬼伞分离的氨基酸序列SEQ ID NO：6的蛋白质。 蛋白质在30至37摄氏度下是稳定的，并且在约45摄氏度和约pH 7下具有最佳的脯氨酰寡肽酶活性。本发明还涉及包含用于治疗由脯氨酸丰富的面筋引起的乳糜泻的蛋白质的药物。
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公开(公告)号：US20110091603A1
公开(公告)日：2011-04-21
申请号：US12754903
申请日：2010-04-06
申请人： Jen-Tao Chen , Chiou-Yen Wen , Fang-Hwa Sheu , Meng-Jen Tsai
发明人： Jen-Tao Chen , Chiou-Yen Wen , Fang-Hwa Sheu , Meng-Jen Tsai
摘要： Disclosed herein is a method of reducing the purine content of an edible material, including treating an edible material having a first level of purine content with a microorganism capable of digesting purine compounds, such that the thus treated edible material has a second level of purine content lower than the first level of purine content, wherein the microorganism is selected from Aspergillus oryzae ATCC 11493, Aspergillus oryzae ATCC 26850, Aspergillus oryzae ATCC 44193, Aspergillus oryzae ATCC 26831, Rhizopus oryzae ATCC 52362, and combinations thereof. An edible material obtained from the aforementioned method is also disclosed.
摘要翻译： 本文公开了一种降低可食用材料的嘌呤含量的方法，包括用能够消化嘌呤化合物的微生物处理具有第一水平的嘌呤含量的可食用物质，使得如此处理的可食用材料具有第二水平的嘌呤含量 低于嘌呤含量的第一水平，其中微生物选自米曲霉ATCC 11493，米曲霉ATCC 26850，米曲霉ATCC 44193，米曲霉ATCC 26831，米曲霉ATCC 52362及其组合。 还公开了从上述方法获得的食用材料。
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公开(公告)号：US08460724B2
公开(公告)日：2013-06-11
申请号：US12754903
申请日：2010-04-06
申请人： Jen-Tao Chen , Chiou-Yen Wen , Fang-Hwa Sheu , Meng-Jen Tsai
发明人： Jen-Tao Chen , Chiou-Yen Wen , Fang-Hwa Sheu , Meng-Jen Tsai
IPC分类号： A23L1/29
摘要： Disclosed herein is a method of reducing the purine content of an edible material, including treating an edible material having a first level of purine content with a microorganism capable of digesting purine compounds, such that the thus treated edible material has a second level of purine content lower than the first level of purine content, wherein the microorganism is selected from Aspergillus oryzae ATCC 11493, Aspergillus oryzae ATCC 26850, Aspergillus oryzae ATCC 44193, Aspergillus oryzae ATCC 26831, Rhizopus oryzae ATCC 52362, and combinations thereof. An edible material obtained from the aforementioned method is also disclosed.
摘要翻译： 本文公开了一种降低可食用材料的嘌呤含量的方法，包括用能够消化嘌呤化合物的微生物处理具有第一水平的嘌呤含量的可食用物质，使得如此处理的可食用材料具有第二水平的嘌呤含量 低于嘌呤含量的第一水平，其中微生物选自米曲霉ATCC 11493，米曲霉ATCC 26850，米曲霉ATCC 44193，米曲霉ATCC 26831，米曲霉ATCC 52362及其组合。 还公开了从上述方法获得的食用材料。
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