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公开(公告)号：US08313916B2
公开(公告)日：2012-11-20
申请号：US12705577
申请日：2010-02-13
申请人： Jennie P. Mather , Deryk T. Loo
发明人： Jennie P. Mather , Deryk T. Loo
IPC分类号： G01N33/574 , C12P21/08 , C07K16/00
CPC分类号： C07K16/3038 , A61K2039/505 , C07K16/40 , G01N33/57407 , G01N33/57484 , G01N33/57492
摘要： The invention provides the identification and characterization of a disease and cancer-associated antigen, KID31. The invention also provides modulators of KID31, including a family of monoclonal antibodies that bind to antigen KID31, and methods of diagnosing and treating various human cancers and diseases with KID31.
摘要翻译： 本发明提供了疾病和癌症相关抗原KID31的鉴定和表征。 本发明还提供KID31的调节剂，包括与抗原KID31结合的单克隆抗体家族，以及用KID31诊断和治疗各种人类癌症和疾病的方法。
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公开(公告)号：US07776328B2
公开(公告)日：2010-08-17
申请号：US12495218
申请日：2009-06-30
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与来自乳腺，肺，前列腺和冒号的各种人类癌症上存在的抗原EphA2结合的抗体的开发和表征的公开。 还公开了通过使用针对该抗原的这种抗体诊断和治疗各种癌症的方法。
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公开(公告)号：US20100183605A1
公开(公告)日：2010-07-22
申请号：US12724564
申请日：2010-03-16
申请人： Jennie P. Mather , Tony W. Liang
发明人： Jennie P. Mather , Tony W. Liang
IPC分类号： A61K39/395
CPC分类号： G01N33/57484 , A61K2039/505 , C07K16/2827 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/77
摘要： The invention provides the identification and characterization of a disease and cancer-associated antigen, TES7. The invention also provides a family of monoclonal antibodies that bind to antigen TES7, methods of diagnosing and treating various human cancers and diseases with TES7.
摘要翻译： 本发明提供疾病和癌症相关抗原TES7的鉴定和表征。 本发明还提供了结合抗原TES7的单克隆抗体家族，用TES7诊断和治疗各种人类癌症和疾病的方法。
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公开(公告)号：US20100111951A1
公开(公告)日：2010-05-06
申请号：US12687512
申请日：2010-01-14
申请人： Jennie P. Mather , Deryk T. Loo
发明人： Jennie P. Mather , Deryk T. Loo
IPC分类号： A61K39/395 , C12N5/02 , A61P35/04
CPC分类号： G01N33/57484 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K16/40 , C07K2317/73 , C07K2317/77 , G01N33/574 , G01N33/57492 , G01N2333/705 , G01N2333/96486
摘要： The invention provides the identification and characterization of a disease and cancer-associated antigen, KID24. The invention also provides modulators of KID24, including a family of monoclonal antibodies that bind to antigen KID24, and methods of diagnosing and treating various human cancers and diseases with KID24.
摘要翻译： 本发明提供了疾病和癌症相关抗原KID24的鉴定和表征。 本发明还提供KID24的调节剂，包括与抗原KID24结合的单克隆抗体家族，以及用KID24诊断和治疗各种人类癌症和疾病的方法。
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公开(公告)号：US20100086969A1
公开(公告)日：2010-04-08
申请号：US12627335
申请日：2009-11-30
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与来自乳腺，肺，前列腺和冒号的各种人类癌症上存在的抗原EphA2结合的抗体的开发和表征的公开。 还公开了通过使用针对该抗原的这种抗体诊断和治疗各种癌症的方法。
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公开(公告)号：US07569672B2
公开(公告)日：2009-08-04
申请号：US11349327
申请日：2006-02-06
IPC分类号： C07K16/00 , C12N5/12 , A61K39/395
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与来自乳腺，肺，前列腺和冒号的各种人类癌症上存在的抗原EphA2结合的抗体的开发和表征的公开。 还公开了通过使用针对该抗原的这种抗体诊断和治疗各种癌症的方法。
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公开(公告)号：US06169070A
公开(公告)日：2001-01-02
申请号：US08628747
申请日：1996-04-17
申请人： Jian Chen , R. Glenn Hammonds , Paul J. Godowski , Melanie R. Mark , Jennie P. Mather , Ronghao Li
发明人： Jian Chen , R. Glenn Hammonds , Paul J. Godowski , Melanie R. Mark , Jennie P. Mather , Ronghao Li
IPC分类号： A61K3818
CPC分类号： C07K14/745 , A61K38/00
摘要： The translation product of the growth arrest-specific gene 6 (gas6) has been identified as an activator of the Mer receptor protein tyrosine kinase. The invention accordingly provides methods of activating Mer receptor in cells expressing it by exposing them to exogenous gas6 polypeptides. Also provided are methods of enhancing the growth, differentiation, or survival of such cells using gas6 polypeptides.
摘要翻译： 生长停滞特异性基因6（gas6）的翻译产物已被鉴定为Mer受体蛋白酪氨酸激酶的激活剂。 因此，本发明提供了通过将它们暴露于外源性气体6多肽来激活表达它的细胞中的Mer受体的方法。 还提供了使用gas6多肽增强这些细胞的生长，分化或存活的方法。
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公开(公告)号：US5286654A
公开(公告)日：1994-02-15
申请号：US12711
申请日：1993-02-03
IPC分类号： C07K14/51 , C07K14/575 , C07K14/71 , G01N33/566 , C07K15/28 , G01N33/536
CPC分类号： C07K14/71 , C07K14/51 , C07K14/575
摘要： An isolated TGF-.beta. supergene family (TSF) receptor polypeptide is provided. This polypeptide preferably is an inhibin/activin receptor polypeptide and has at least 75% sequence identity with the mature human inhibin/activin receptor sequence. Also provided is a method for purifying TGF-.beta. supergene family members such as inhibin or activin using the polypeptide, and a method for screening for compounds with TGF-.beta. supergene family member activity by contacting the compound with the polypeptide and detecting if binding has occurred and the compound is active.
摘要翻译： 提供分离的TGF-β超基因家族（TSF）受体多肽。 该多肽优选是抑制素/激活素受体多肽，并且与成熟的人抑制素/激活素受体序列具有至少75％的序列同一性。 还提供了使用该多肽纯化TGF-β超级基因家族成员如抑制素或激活素的方法，以及通过使化合物与多肽接触并检测是否发生结合而筛选具有TGF-β超基因家族成员活性的化合物的方法 并且化合物是活性的。
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公开(公告)号：US08309354B2
公开(公告)日：2012-11-13
申请号：US12018126
申请日：2008-01-22
CPC分类号： C12N5/0695
摘要： This invention discloses isolated populations of human cancer stem cells. Methods for characterizing, isolating and culturing human cancer stem cells are also disclosed. Uses for human cancer stem cells are provided.
摘要翻译： 本发明公开了人类癌症干细胞的分离群体。 还公开了表征，分离和培养人类癌症干细胞的方法。 提供用于人类癌症干细胞的用途。
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公开(公告)号：US08216578B2
公开(公告)日：2012-07-10
申请号：US12497439
申请日：2009-07-02
IPC分类号： A61K39/395
CPC分类号： G01N33/57492 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K16/30 , C07K2317/73 , G01N33/574 , G01N2333/715
摘要： The invention provides characterization of the disease and cancer-associated antigen, OSM-R.beta. The invention also provides modulators of OSM-R.beta, including a family of monoclonal antibodies that bind to antigen OSM-R.beta, and methods of diagnosing and treating various human cancers and diseases associated with OSM-R.beta.
摘要翻译： 本发明提供了疾病和癌症相关抗原的表征，OSM-R.beta。 本发明还提供OSM-R.beta的调节剂，其包括与抗原OSM-R.beta结合的单克隆抗体家族，以及诊断和治疗与OSM-R.beta相关的各种人类癌症和疾病的方法。
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