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公开(公告)号：US20100304465A1
公开(公告)日：2010-12-02
申请号：US11568023
申请日：2005-04-21
Applicant: Jennifer A. Hunt , Valery Novokhatny
Inventor： Jennifer A. Hunt , Valery Novokhatny
CPC classification number: C12N9/6435 , C12Y304/21007
Abstract: Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.
Abstract translation: 提供了与重组修饰的纤溶酶（原）分子相关的多核苷酸和多肽。 纤溶酶原（Ogen）分子在天然人纤溶酶原分子中存在活化位点的N-末端单个三环结构域，并显示与天然酶相关的赖氨酸结合和显着的酶特征。
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公开(公告)号：US08231869B2
公开(公告)日：2012-07-31
申请号：US12090782
申请日：2006-10-18
Applicant: Philip Scuderi, Jr. , Vikram Arora , Jennifer A. Hunt , Valery Novokhatny , Stephen R. Petteway, Jr.
Inventor： Philip Scuderi, Jr. , Vikram Arora , Jennifer A. Hunt , Valery Novokhatny , Stephen R. Petteway, Jr.
IPC: A61K38/48
CPC classification number: C12Y304/21007 , A61K38/484 , C12N9/6435
Abstract: Methods of using polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided, including methods related to vitrectomy or vitreolysis. The plasmin(ogen) molecule has a single kringel domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.
Abstract translation: 提供使用与重组修饰的纤溶酶（ogen）分子相关的多核苷酸和多肽的方法，包括与玻璃体切割术或玻璃体解分解相关的方法。 纤溶酶原（Ogen）分子具有与天然人纤溶酶原分子中存在的活化位点N末端的单个kringel结构域，并显示与天然酶相关的赖氨酸结合和显着的酶特征。
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公开(公告)号：US08034913B2
公开(公告)日：2011-10-11
申请号：US11568023
申请日：2005-04-21
Applicant: Jennifer A. Hunt , Valery Novokhatny
Inventor： Jennifer A. Hunt , Valery Novokhatny
CPC classification number: C12N9/6435 , C12Y304/21007
Abstract: Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.
Abstract translation: 提供了与重组修饰的纤溶酶（原）分子相关的多核苷酸和多肽。 纤溶酶原（Ogen）分子在天然人纤溶酶原分子中存在活化位点的N-末端单个三环结构域，并显示与天然酶相关的赖氨酸结合和显着的酶特征。
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公开(公告)号：US20100047228A1
公开(公告)日：2010-02-25
申请号：US12090782
申请日：2006-10-18
Applicant: Philip Scuderi, JR. , Vikram Arora , Jennifer A. Hunt , Valery Novokhatny , Stephen R. Petteway, JR.
Inventor： Philip Scuderi, JR. , Vikram Arora , Jennifer A. Hunt , Valery Novokhatny , Stephen R. Petteway, JR.
IPC: A61K38/48
CPC classification number: C12Y304/21007 , A61K38/484 , C12N9/6435
Abstract: Methods of using polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided, including methods related to vitrectomy or vitreolysis. The plasmin(ogen) molecule has a single kringel domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.
Abstract translation: 提供使用与重组修饰的纤溶酶（ogen）分子相关的多核苷酸和多肽的方法，包括与玻璃体切割术或玻璃体解分解相关的方法。 纤溶酶原（Ogen）分子具有与天然人纤溶酶原分子中存在的活化位点N末端的单个kringel结构域，并显示与天然酶相关的赖氨酸结合和显着的酶特征。
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公开(公告)号：US20110318812A1
公开(公告)日：2011-12-29
申请号：US13223373
申请日：2011-09-01
Applicant: Jennifer A. Hunt , Valery Novokhatny
Inventor： Jennifer A. Hunt , Valery Novokhatny
IPC: C12N9/68
CPC classification number: C12N9/6435 , C12Y304/21007
Abstract: Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.
Abstract translation: 提供了与重组修饰的纤溶酶（原）分子相关的多核苷酸和多肽。 纤溶酶原（Ogen）分子在天然人纤溶酶原分子中存在活化位点的N-末端单个三环结构域，并显示与天然酶相关的赖氨酸结合和显着的酶特征。
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Patent Agency Ranking
公开(公告)号：US08420079B2
公开(公告)日：2013-04-16
申请号：US13223373
申请日：2011-09-01
Applicant: Jennifer Hunt , Valery Novokhatny
Inventor： Jennifer Hunt , Valery Novokhatny
CPC classification number: C12N9/6435 , C12Y304/21007
Abstract: Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.
Abstract translation: 提供了与重组修饰的纤溶酶（原）分子相关的多核苷酸和多肽。 纤溶酶原（Ogen）分子在天然人纤溶酶原分子中存在活化位点的N-末端单个三环结构域，并显示与天然酶相关的赖氨酸结合和显着的酶特征。
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公开(公告)号：US20120093799A1
公开(公告)日：2012-04-19
申请号：US13302322
申请日：2011-11-22
Applicant: Valery Novokhatny
Inventor： Valery Novokhatny
CPC classification number: C12N9/6435 , C07K2319/00 , C12N11/04 , C12Y304/21007
Abstract: Polynucleotides and polypeptides relating to a recombinantly modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme
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公开(公告)号：US20080311105A1
公开(公告)日：2008-12-18
申请号：US12197617
申请日：2008-08-25
Applicant: Thomas P. Zimmerman , Valery Novokhatny , Shan Jiang , James Colandene
Inventor： Thomas P. Zimmerman , Valery Novokhatny , Shan Jiang , James Colandene
IPC: A61K38/48
CPC classification number: C12N9/6435 , A61K38/4833 , A61K38/484 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , C12N9/96 , C12N9/99 , C12Y304/21007
Abstract: The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.
Abstract translation: 本发明提供一种纤维蛋白溶解组合物，其可用作用于给予具有血栓闭塞的患者的治疗剂。 在本发明的一个方面，纤维蛋白溶解组合物包含基本上不含纤溶酶原激活剂的可逆失活的酸化丝氨酸蛋白酶，低缓冲能力的缓冲液和任选的稳定剂。 在本发明的另一方面，本发明的纤维蛋白溶解组合物包含基本上不含纤溶酶原激活剂，低缓冲能力缓冲液和任选的稳定剂的可逆灭活的酸化纤溶酶。
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公开(公告)号：US20120276611A1
公开(公告)日：2012-11-01
申请号：US13463437
申请日：2012-05-03
Applicant: Valery Novokhatny
Inventor： Valery Novokhatny
CPC classification number: C12N9/6435 , C07K2319/00 , C12N11/04 , C12Y304/21007
Abstract: Polynucleotides and polypeptides relating to a recombinantly modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme
Abstract translation: 提供了与重组修饰的纤溶酶（原）分子相关的多核苷酸和多肽。 纤溶酶原（Ogen）分子在天然人纤溶酶原分子中具有与存在于天然人纤溶酶原分子中的活化位点N末端的单个三环结构域，使得不存在外来序列，并显示与天然酶相关的赖氨酸结合和显着的酶特征
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公开(公告)号：US08182808B2
公开(公告)日：2012-05-22
申请号：US13302322
申请日：2011-11-22
Applicant: Valery Novokhatny
Inventor： Valery Novokhatny
CPC classification number: C12N9/6435 , C07K2319/00 , C12N11/04 , C12Y304/21007
Abstract: Polynucleotides and polypeptides relating to a recombinantly modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.
Abstract translation: 提供了与重组修饰的纤溶酶（原）分子相关的多核苷酸和多肽。 纤溶酶原（Ogen）分子具有与天然人纤溶酶原分子中存在的活化位点N末端的单个三环结构域，其组合使得不存在外来序列，并显示与天然酶相关的赖氨酸结合和显着的酶特征。
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