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1.发明申请公开(公告)号：US20140073518A1
公开(公告)日：2014-03-13
申请号：US13883216
申请日：2011-11-07
IPC分类号： C07K14/705 , C07K14/47 , C07K14/475 , C07K14/81
CPC分类号： C07K14/705 , C07K14/43518 , C07K14/47 , C07K14/4702 , C07K14/475 , C07K14/71 , C07K14/81 , C07K14/8121 , C07K2319/00
摘要： The present disclosure presents a general approach to engineering existing protein-protein interactions through domain addition and evolution. The disclosure teaches the creation of novel fusion proteins that include knottin peptides where a portion of the knottin peptide is replaced with a sequence that has been created for binding to a particular target. Such fusion proteins can also be bispecific or multi specific in that they can bind to and/or inhibit two or more receptors or receptor ligands. Knottins may be fused with an existing ligand (or receptor) as a general platform for increasing the affinity of a ligand-receptor interaction or for creating a multi specific protein. In addition, the fusion proteins may comprise a knottin peptide fused to another protein where the other protein facilitates proper expression and folding of the knottin.
摘要翻译： 本公开提出了通过域添加和进化来设计现有蛋白质 - 蛋白质相互作用的一般方法。 该公开内容教导了包括knottin肽的新型融合蛋白的产生，其中一部分knottin肽被用于结合特定靶标的序列替代。 这样的融合蛋白也可以是双特异性或多特异性的，因为它们可以结合和/或抑制两种或多种受体或受体配体。 Knottins可以与现有配体（或受体）融合，作为增加配体 - 受体相互作用或产生多特异性蛋白质的亲和力的通用平台。 此外，融合蛋白可以包含与另一种蛋白质融合的knottin肽，其中另一种蛋白促进knottin的正确表达和折叠。
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2.发明申请HEPATOCYTE GROWTH FACTOR FRAGMENTS THAT FUNCTION AS POTENT MET RECEPTOR AGONISTS AND ANTAGONISTS 有权HEPATOCYTE生长因子片段功能作为MET受体激动剂和拮抗剂公开(公告)号：US20130171068A1
公开(公告)日：2013-07-04
申请号：US13636053
申请日：2011-03-21
IPC分类号： C07K14/475
CPC分类号： C07K14/4753 , A61K38/00
摘要： The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role in embryonic development and organ formation. The instant application discloses NK1 variant polypeptides which act as agonists or antagonists of HGF. Further disclosed are covalently linked NK1 variant polypeptides. Many of the disclosed variant polypeptides possess improved stability characteristics.
摘要翻译： 肝细胞生长因子（HGF）的NK1片段结合并激活Met受体，一种跨膜受体酪氨酸激酶，在胚胎发育和器官形成中起关键作用。 本申请公开了作为HGF的激动剂或拮抗剂的NK1变体多肽。 进一步公开的是共价连接的NK1变体多肽。 所公开的变体多肽中的许多具有改善的稳定性特征。
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3.发明授权Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists 有权作为有效的受体激动剂和拮抗剂起作用的肝细胞生长因子片段公开(公告)号：US09556248B2
公开(公告)日：2017-01-31
申请号：US13636053
申请日：2011-03-21
IPC分类号： A61K38/18 , C07K14/475 , A61K38/00
CPC分类号： C07K14/4753 , A61K38/00
摘要： The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role in embryonic development and organ formation. The instant application discloses NK1 variant polypeptides which act as agonists or antagonists of HGF. Further disclosed are covalently linked NK1 variant polypeptides. Many of the disclosed variant polypeptides possess improved stability characteristics.
摘要翻译： 肝细胞生长因子（HGF）的NK1片段结合并激活Met受体，一种跨膜受体酪氨酸激酶，在胚胎发育和器官形成中起关键作用。 本申请公开了作为HGF的激动剂或拮抗剂的NK1变体多肽。 进一步公开的是共价连接的NK1变体多肽。 所公开的变体多肽中的许多具有改善的稳定性特征。
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