公开(公告)号：US20060070950A1

公开(公告)日：2006-04-06

申请号：US11238595

申请日：2005-09-29

申请人： Jerald Rasmussen ,  Andrew Rabins ,  James Hembre ,  Kannan Seshadri ,  Kelly Gibbens ,  Masayuki Nakamura ,  Robert Fitzsimons ,  Simon Shannon ,  Stephen Roscoe ,  Larry Carson

发明人： Jerald Rasmussen ,  Andrew Rabins ,  James Hembre ,  Kannan Seshadri ,  Kelly Gibbens ,  Masayuki Nakamura ,  Robert Fitzsimons ,  Simon Shannon ,  Stephen Roscoe ,  Larry Carson

IPC分类号： B01D15/08

CPC分类号： B01J20/285 ,  B01D15/22 ,  B01D15/265 ,  B01D15/327 ,  B01D15/361 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3804 ,  B01D39/1623 ,  B01D39/18 ,  B01D39/2017 ,  B01D2239/0407 ,  B01J20/261 ,  B01J20/262 ,  B01J20/265 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28033 ,  B01J20/28042 ,  B01J20/28052 ,  B01J2220/58 ,  B01J2220/66 ,  B01J2220/82

摘要： A composite filter medium comprising a filter element comprising at least one porous fibrous filtration layer, and at least one layer of a sorbent, stationary phase particulates selected from organic or inorganic particulates having an average diameter of less than 50 micrometers, soft particulates, and ground monolithic particulates. The particulates are capable of binding target molecule by, for example, adsorption, ion exchange, hydrophobic binding, and affinity binding. The particulates provide higher binding capacities than can be achieved using filter media incorporating conventional process scale chromatography resin particulates.

摘要翻译： 一种复合过滤介质，其包含至少一个多孔纤维过滤层的过滤元件和至少一层吸附剂，静态相颗粒，其选自平均直径小于50微米的有机或无机颗粒，软颗粒和地面 整体颗粒物 颗粒能够通过例如吸附，离子交换，疏水结合和亲和结合来结合靶分子。 与使用包含常规工艺规模色谱树脂颗粒的过滤介质相比，颗粒提供更高的结合能力。

公开(公告)号：US20070075022A1

公开(公告)日：2007-04-05

申请号：US11241524

申请日：2005-09-30

申请人： Kelly Gibbens ,  Masayuki Nakamura ,  Kannan Seshadri ,  Andrew Rabins ,  Larry Carson ,  Robert Fitzsimons

发明人： Kelly Gibbens ,  Masayuki Nakamura ,  Kannan Seshadri ,  Andrew Rabins ,  Larry Carson ,  Robert Fitzsimons

IPC分类号： B01D15/08

CPC分类号： B01D15/1828 ,  B01D15/1842

摘要： A single pass simulated moving bed apparatus and methods are described for continuously separating a target molecule from a liquid mixture, using a simulated moving bed system. The simulated moving bed system includes a plurality of filter cartridge modules in serial fluid communication. Each filter cartridge module includes a volume of stationary phase particulates adjacent a porous substrate layer. The volume of stationary phase particulates has a bed height of less than 1 centimeter.

摘要翻译： 描述了使用模拟移动床系统连续分离目标分子与液体混合物的单程模拟移动床装置和方法。 模拟移动床系统包括串联流体连通的多个滤芯模块。 每个过滤器滤芯模块包括邻近多孔基底层的体积的固定相颗粒。 固定相颗粒的体积具有小于1厘米的床高度。

公开(公告)号：US20060070955A1

公开(公告)日：2006-04-06

申请号：US11241482

申请日：2005-09-30

申请人： Andrew Rabins ,  Kelly Gibbens ,  Masayuki Nakamura ,  Kannan Seshadri ,  Robert Fitzsimons ,  Larry Carson ,  Stephen Larsen

发明人： Andrew Rabins ,  Kelly Gibbens ,  Masayuki Nakamura ,  Kannan Seshadri ,  Robert Fitzsimons ,  Larry Carson ,  Stephen Larsen

IPC分类号： B01D15/08

CPC分类号： B01J20/28033 ,  B01D15/1828

摘要： A simulated moving bed apparatus and methods are described for continuously separating a target molecule from a liquid mixture, using a simulated moving bed system. The simulated moving bed system includes a plurality of filter cartridge modules in serial fluid communication. Each filter cartridge module includes a volume of stationary phase particulates adjacent a porous substrate layer. Each filter cartridge module also includes recirculation piping in fluid connection with a filter cartridge outlet and a filter cartridge inlet.