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公开(公告)号：US20240359161A1
公开(公告)日：2024-10-31
申请号：US18647811
申请日：2024-04-26
Applicant: Waters Technologies Corporation
Inventor： Kevin Wyndham , Beatrice Muriithi , Oksana Tchoul , Yeliz Tunc Sarisozen , MingCheng Xu , Matthew Lauber
CPC classification number: B01J20/289 , B01D15/22 , B01D15/3809 , B01J20/261 , B01J20/28004 , B01J20/28016 , B01J20/321 , B01J20/3219 , B01J20/3274
Abstract: The present disclosure is directed to nonporous polymer particles having an average particle size of 1 to 10 micrometers and being functionalized with streptavidin. The streptavidin functionalized particles of the present disclosure can be bound to biotinylated antibodies, biotinylated antigen-binding fragments thereof, or biotinylated oligonucleotides to create customizable affinity chromatography columns. That is, the functionalized nonporous polymer particles can be packed in a stainless steel, titanium, or other metal or metal alloy column for affinity high pressure liquid chromatography (HPLC).
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公开(公告)号：US12129935B2
公开(公告)日：2024-10-29
申请号：US18196321
申请日：2023-05-11
Applicant: Tosoh Bioscience LLC
Inventor： Brian A. Harbrecht , Robert Charles Mierendorf , Scott G. Manke
CPC classification number: F16K7/17 , B01D15/1842 , B01D15/22 , F16K11/22 , F16K25/005 , F16K27/003 , F16K27/0236 , F16K27/0263 , F16K31/1266
Abstract: A valve block includes a fluid-transfer plate with multiple inlet bores connecting to a common inlet channel, and multiple outlet bores connecting to a common outlet channel. The inlet bores and the outlet bores are arranged in a curved shape. The valve block also includes a pressure plate and diaphragm aligned and connected to the fluid-transfer plate in a way that allows pressurized material in the pressure plate to control the state of the channels formed by the inlet and outlet bores.
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公开(公告)号：US20240279797A1
公开(公告)日：2024-08-22
申请号：US18649231
申请日：2024-04-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
CPC classification number: C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
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公开(公告)号：US20240279795A1
公开(公告)日：2024-08-22
申请号：US18649171
申请日：2024-04-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
CPC classification number: C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
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公开(公告)号：US20240279794A1
公开(公告)日：2024-08-22
申请号：US18649035
申请日：2024-04-29
Applicant: Agilent Technologies, Inc.
Inventor： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
CPC classification number: C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
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Patent Agency Ranking
公开(公告)号：US20240278212A1
公开(公告)日：2024-08-22
申请号：US18112806
申请日：2023-02-22
Applicant: KING SAUD UNIVERSITY
Inventor： Ahmed Yacine Badjah Hadj AHMED , Mohamed Ali OULADSMANE , Taieb AOUAK , Zeid Abdullah ALOTHMAN
CPC classification number: B01J20/286 , B01D15/22 , B01J20/267 , B01J20/28042 , B01J20/3092 , B01J20/3219 , B01J2220/58 , B01J2220/82 , B01J2220/84 , B01J2220/86
Abstract: The chromatographic column is a stainless steel column having a stationary phase of porous monolithic polymer chemically bonded to the interior wall of the stainless steel column so that the stationary phase is fixed and immobile and does not require frits or other seals to retain particulate matter or a slurry in the column. The inner wall of the column is oxidized and then vinylized with a difunctional linker to chemically bond the polymer to the column. The difunctional linker may be 3-(trimethoxysilyl) propyl methacrylate, vinyl trimethoxysilane, 3-mercaptopropyl trimethoxysilane, or glycidoxypropyltrimethoxysilane. The monolithic polymer is prepared in situ in the column by radical polymerization of a monovinyl monomer with a crosslinking divinyl monomer. The column may be a conventional stainless steel column (¼″ inner diameter), capillary micro-LC ( 1/16″), or nan-LC (( 1/32″).
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公开(公告)号：US20240261704A1
公开(公告)日：2024-08-08
申请号：US18623582
申请日：2024-04-01
Applicant: SUPERCRITICAL FLUID TECHNOLOGIES, INC.
Inventor： Kenneth Richard Krewson , Andrew Cloud , Kenneth Joseph James , Curtis EBERSOLD , Kim FERRARA
CPC classification number: B01D15/22 , B01D15/20 , B01D53/025 , B01D2256/22
Abstract: A chromatography system has a cartridge adapter that is detachably attachable to enable a chromatography cartridge to be quickly interchanged. Chromatography cartridges are configured with threads for coupling to a corresponding interchangeable coupling component having matching threads. The interchangeable coupling component may be secured to the chromatography system by a coupling retainer. A coupling retainer may have a keyway that is configured for quick interchanging of the interchangeable coupling components. The interchangeable coupling component may have a pair of parallel sides that align with a slot of the keyway to secure the interchangeable coupling components to the coupling retainer. An inlet nipple of the chromatography cartridge may extend through an opening in the coupling components and couple to an inlet conduit for sample gas. Analyte gas may flow back to the chromatography system for detection and collection.
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公开(公告)号：US11911711B2
公开(公告)日：2024-02-27
申请号：US17938653
申请日：2022-10-06
Applicant: Cytiva BioProcess R&D AB
Inventor： Klaus Gebauer
CPC classification number: B01D15/14 , B01D15/1864 , B01D15/1885 , B01D15/22 , G01N30/466 , G01N30/6043 , G01N30/6091 , G01N30/6039 , G01N2030/8881 , Y10T29/49826
Abstract: A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
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公开(公告)号：US20240024796A1
公开(公告)日：2024-01-25
申请号：US18224941
申请日：2023-07-21
Applicant: Detect-Ion LLC
Inventor： Ashish Chaudhary , Dustin McRae
CPC classification number: B01D15/18 , B01D15/14 , B01D15/161 , B01D15/22
Abstract: A fluid chromatography device, comprising a first segment of a column configured to connect with an inlet that is configured to receive a fluid sample. The fluid chromatography device includes a second segment of the column in fluid communication with the first segment at a connection and an in-line exhaust in fluid communication with the first segment at the connection between the first and second segments. The in-line exhaust vents the fluid sample from the first segment until closed. The in-line exhaust closes after a period of time after a sample is injected into the first segment. The flow rate of the fluid sample of the first segment before the in-line exhaust closes is higher than a flow rate of the fluid sample of the first and second segments after the in-line exhaust closes.
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公开(公告)号：US11865510B2
公开(公告)日：2024-01-09
申请号：US17047753
申请日：2019-04-16
Applicant: ALMA MATER STUDIORUM-UNIVERSITA' DI BOLOGNA
Inventor： Giuseppina Paola Parpinello , Andrea Versari , Luigi Ragni , Arianna Ricci , Marina Serantoni , Andrea Balducci
CPC classification number: B01J20/06 , A23L2/80 , B01D15/203 , B01D15/206 , B01D15/22 , B01J20/282 , B01J20/28021 , B01J20/28052 , B01J20/28059 , B01J20/28061 , B01J20/28071 , B01J20/28073 , B01J20/28083 , B01J20/3433 , B01J20/3475 , C12H1/0408 , A23V2002/00 , B01J2220/52
Abstract: A device and a method for stabilizing wine or other vegetable beverages by removal, in whole or in part, of agents responsible for instability, including proteins and metals, are provided. The device has a tubular container filled internally at least partly with particles of support material covered with a layer of a mesoporous nanostructured adsorbent material comprising titanium oxide, adapted to absorb proteins and metals.
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