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1.
公开(公告)号:US20060241109A1
公开(公告)日:2006-10-26
申请号:US11360885
申请日:2006-02-23
申请人: Jeremy Little , Shomir Ghosh , Sean Harrison , Amy Elder , Christelle Renou , Kenneth Carson
发明人: Jeremy Little , Shomir Ghosh , Sean Harrison , Amy Elder , Christelle Renou , Kenneth Carson
IPC分类号: A61K31/538 , A61K31/498 , A61K31/4709 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号: C07D413/12 , C07D215/50 , C07D401/06 , C07D401/12 , C07D409/06 , C07D413/06 , C07D471/04 , C07D495/04
摘要: Disclosed are CRTH2 inhibitors represented by Structural Formula (I): The values for the variables of Structural Formula (I) are provided herein.
摘要翻译: 公开了由结构式(I)表示的CRTH2抑制剂:本文提供了结构式(I)的变量的值。
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2.
公开(公告)号:US20050256158A1
公开(公告)日:2005-11-17
申请号:US11101208
申请日:2005-04-07
申请人: Shomir Ghosh , Amy Elder , Kenneth Carson , Kevin Sprott , Sean Harrison , Frederick Hicks , Christelle Renou , Dominic Reynolds
发明人: Shomir Ghosh , Amy Elder , Kenneth Carson , Kevin Sprott , Sean Harrison , Frederick Hicks , Christelle Renou , Dominic Reynolds
IPC分类号: A61K31/47 , A61K31/4709 , C07D215/38 , C07D215/42 , C07D215/44 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/06 , C07D413/10 , C07D417/06
CPC分类号: C07D405/06 , C07D215/42 , C07D215/44 , C07D401/04 , C07D401/06 , C07D401/12 , C07D413/06 , C07D413/10 , C07D417/06
摘要: Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
摘要翻译: 本文公开的是由结构式(I)和(IA)表示的化合物:还公开了这样的化合物用于抑制称为Th2上表达的化学引诱物受体同源分子的G-蛋白偶联受体,或简称为“CRTH2”,用于 治疗炎症性疾病。 结构式(I)和(I-A)中的变量在本文中定义。
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