Dosage forms comprising polymers comprising different molecular weights
    2.
    发明授权
    Dosage forms comprising polymers comprising different molecular weights 失效
    包含包含不同分子量的聚合物的剂型

    公开(公告)号:US5208037A

    公开(公告)日:1993-05-04

    申请号:US688807

    申请日:1991-04-22

    IPC分类号: A61K9/00 A61K9/22 A61K47/38

    CPC分类号: A61K9/0004

    摘要: A dosage form is disclosed comprising a wall surrounding a compartment, which comprises a first composition comprising a carboxymethylcellulose and a second composition comprising a higher molecular weigh carboxymethylcellulose. The first composition comprises a dosage amount of drug that delivers from the dosage form at a controlled rate over time.

    摘要翻译: 公开了一种剂型,其包括围绕隔室的壁,其包含含有羧甲基纤维素的第一组合物和包含较高分子量的羧甲基纤维素的第二组合物。 第一组合物包含以受控速率随时间从剂型递送的剂量的药物。

    Oral osmotic device with hydrogel driving member
    5.
    发明授权
    Oral osmotic device with hydrogel driving member 失效
    具有水凝胶驱动构件的口腔渗透装置

    公开(公告)号:US5248310A

    公开(公告)日:1993-09-28

    申请号:US859191

    申请日:1992-03-27

    IPC分类号: A61K9/00 A61K9/22

    CPC分类号: A61K9/0004

    摘要: An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an agent (14) that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the agent (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the beneficial agent (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of drug/agent (14) which has been delivered and/or the amount remaining to be delivered.

    摘要翻译: 公开了一种用于将有益药物(例如抗真菌)递送到人类患者的口中的渗透装置(10)。 装置(10)具有适应其舒适地保持在口中长时间的尺寸和形状。 装置(10)包括围绕隔室(13)的壁(12),该隔室(13)容纳不溶于非常可溶于水生物流体(例如唾液)的试剂(14)层,以及流体层 可溶胀的亲水性聚合物。 壁(12)中的通道(17)将试剂(14)与装置(10)的外部连接。 所述壁(12)对于水性生物流体的通道是可渗透的,但是对于亲水性聚合物(16)的通过基本上是不透水的。 在一个实施方案中,有益剂(14)具有与亲水性聚合物(16)不同的颜色。 壁(12)是足够半透明的,以允许患者看到待传送的药物/有益剂(14)的量。 标记线(19)可以设置在壁(12)上,指示已经被输送的药物/试剂(14)的量和/或剩余的待传送量。

    Oral osmotic device with hydrogel driving member
    8.
    发明授权
    Oral osmotic device with hydrogel driving member 失效
    具有水凝胶驱动构件的口腔渗透装置

    公开(公告)号:US5573776A

    公开(公告)日:1996-11-12

    申请号:US303288

    申请日:1994-09-08

    IPC分类号: A61K9/00 A61K31/48 A61K9/24

    CPC分类号: A61K31/48 A61K9/0004

    摘要: An osmotic device (10) for delivering an ergot alkaloid into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an ergot alkaloid (14) and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the ergot alkaloid (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the ergot alkaloid (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of ergot alkaloid (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of ergot alkaloid (14) which has been delivered and/or the amount remaining to be delivered.

    摘要翻译: 公开了一种用于将麦角生物碱输送到人类患者的口中的渗透装置(10)。 装置(10)具有适应其舒适地保持在口中长时间的尺寸和形状。 装置(10)包括围绕容纳一角麦角生物碱(14)层和流体可溶胀的亲水性聚合物层(16)的隔室(13)的壁(12)。 壁(12)中的通道(17)将麦角生物碱(14)与装置(10)的外部连接。 所述壁(12)对于水性生物流体的通道是可渗透的,但是对于亲水性聚合物(16)的通过基本上是不透水的。 在一个实施方案中,麦角生物碱(14)具有与亲水性聚合物(16)不同的颜色。 壁(12)足够半透明以允许患者看到剩余的待转运麦角生物碱(14)的量。 标记线(19)可以设置在壁(12)上,指示已经输送的麦角生物碱(14)的量和/或剩余的待传送量。