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28 条记录 (耗时 0.024 秒)

    Oral osmotic device with hydrogel driving member
    2.
    发明授权
    Oral osmotic device with hydrogel driving member 失效
    具有水凝胶驱动构件的口腔渗透装置

    公开(公告)号：US5573776A

    公开(公告)日：1996-11-12

    申请号：US303288

    申请日：1994-09-08

    申请人： Juan M. E. Harrison ,  Brian L. Barclay ,  Jerry D. Childers ,  Jeri D. Wright ,  Virgil A. Place ,  Patrick S. Wong

    发明人： Juan M. E. Harrison ,  Brian L. Barclay ,  Jerry D. Childers ,  Jeri D. Wright ,  Virgil A. Place ,  Patrick S. Wong

    IPC分类号： A61K9/00 ,  A61K31/48 ,  A61K9/24

    CPC分类号： A61K31/48 ,  A61K9/0004

    摘要： An osmotic device (10) for delivering an ergot alkaloid into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an ergot alkaloid (14) and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the ergot alkaloid (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the ergot alkaloid (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of ergot alkaloid (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of ergot alkaloid (14) which has been delivered and/or the amount remaining to be delivered.

    摘要翻译： 公开了一种用于将麦角生物碱输送到人类患者的口中的渗透装置（10）。 装置（10）具有适应其舒适地保持在口中长时间的尺寸和形状。 装置（10）包括围绕容纳一角麦角生物碱（14）层和流体可溶胀的亲水性聚合物层（16）的隔室（13）的壁（12）。 壁（12）中的通道（17）将麦角生物碱（14）与装置（10）的外部连接。 所述壁（12）对于水性生物流体的通道是可渗透的，但是对于亲水性聚合物（16）的通过基本上是不透水的。 在一个实施方案中，麦角生物碱（14）具有与亲水性聚合物（16）不同的颜色。 壁（12）足够半透明以允许患者看到剩余的待转运麦角生物碱（14）的量。 标记线（19）可以设置在壁（12）上，指示已经输送的麦角生物碱（14）的量和/或剩余的待传送量。

    Method for delivering an agent with biocidal activity in a body fluid receiving container
    5.
    发明授权
    Method for delivering an agent with biocidal activity in a body fluid receiving container 失效
    用于在体液接收容器中递送具有杀生物活性的药剂的方法

    公开(公告)号：US4445889A

    公开(公告)日：1984-05-01

    申请号：US397507

    申请日：1982-07-12

    申请人： Patrick S. Wong ,  Jimmy B. Langston ,  Harold M. Leeper

    发明人： Patrick S. Wong ,  Jimmy B. Langston ,  Harold M. Leeper

    IPC分类号： A61F5/44 ,  A61M1/00 ,  A61M31/00

    CPC分类号： A61F5/44 ,  A61M1/0096

    摘要： A method for preventing an infection in a patient introduced through a indwelling catheter, the method comprising, connecting the patient to the catheter, connecting the catheter to a fluid receiving container, admitting into the container a biocidal dispensing device, and releasing a biocide into fluid in the container for inhibiting the growth of infectious bacteria in the container and concomitantly their introduction into the catheter and the patient.

    摘要翻译： 一种用于防止通过留置导管引入的患者的感染的方法，所述方法包括：将患者连接到导管，将导管连接到流体接收容器，将容器中的杀生物剂分配装置，以及将杀生物剂释放到流体中 在用于抑制容器中的感染性细菌生长的容器中并且伴随地引入到导管和患者体内。

    Vaginal dispenser for dispensing beneficial hormone
    8.
    发明授权
    Vaginal dispenser for dispensing beneficial hormone 失效
    用于分配有益激素的阴道分配器

    公开(公告)号：US4629449A

    公开(公告)日：1986-12-16

    申请号：US714421

    申请日：1985-03-21

    申请人： Patrick S. Wong

    发明人： Patrick S. Wong

    IPC分类号： A61K9/00 ,  A61M31/00

    CPC分类号： A61M31/002 ,  A61K9/0036

    摘要： The invention is for a method of treating a decrease in estrogen secretion in a woman after the cessation of cyclic ovulation using a vaginal dispenser comprising a wall surrounding an internal lumen and having a pair of ends with one end placed inside the other end to form a closed dispenser. A vaginally administrable beneficial agent is housed in the lumen for release by the dispenser over time.

    摘要翻译： 本发明是一种治疗妇女循环排卵后雌激素分泌减少的方法，该方法使用阴道分配器，该阴道分配器包括围绕内腔的壁，并具有一端，一端位于另一端的内部，以形成 封闭式分配器。 阴道给药的有益剂容纳在管腔中以随着时间的推移被分配器释放。

    Method of delivering drug with aid of effervescent activity generated in environment of use
    9.
    发明授权
    Method of delivering drug with aid of effervescent activity generated in environment of use 失效
    通过使用环境中产生的泡腾活性来输送药物的方法

    公开(公告)号：US4344929A

    公开(公告)日：1982-08-17

    申请号：US228091

    申请日：1981-01-26

    申请人： Pieter Bonsen ,  Patrick S. Wong ,  Felix Theeuwes

    发明人： Pieter Bonsen ,  Patrick S. Wong ,  Felix Theeuwes

    IPC分类号： A61K9/00 ,  A61K9/46 ,  A61J1/00

    CPC分类号： A61K9/0004

    摘要： A method is disclosed for delivering a drug substantially-free of rapid precipitation from an osmotic device. The osmotic device comprises a semipermeable wall surrounding a compartment housing (1) a drug that exhibits limited solubility under neutral and acid conditions, and (2) a compound capable of evolving carbon dioxide in the presence of an acid in the environment of use. The method comprises, (a) imbibing fluid through the wall into the compartment at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, (b) forming in the compartment a basic solution containing drug and compound, which solution is delivered from the compartment through the passageway, (c) reacting the compound with the acid in the environment at the device-environment interface for evolving carbon dioxide, thereby, (d) providing an effervescent suspension in the environment that delivers the drug in a finely dispersed form to the environment of use over time. Also, a composition is disclosed comprising the drug and the compound.

    摘要翻译： 公开了用于从渗透装置输送基本上不含快速沉淀的药物的方法。 渗透装置包括围绕隔室壳体（1）的半透壁，其在中性和酸性条件下表现出有限的溶解性，和（2）能够在使用环境中存在酸的情况下能够释放二氧化碳的化合物。 该方法包括：（a）将流体通过所述壁吸入所述隔室中，所述速率由所述壁的渗透性和穿过所述壁的渗透压梯度确定，（b）在所述室中形成含有药物和化合物的碱性溶液， 溶液通过通道从隔室输送，（c）使化合物与环境中的酸在设备 - 环境界面反应，用于放出二氧化碳，从而（d）在环境中提供泡腾悬浮液，将环境中的药物递送 随着时间的推移，使用环境的细分散形式。 另外，公开了包含药物和化合物的组合物。

    Process for manufacturing dosage form
    10.
    发明授权
    Process for manufacturing dosage form 失效
    制剂剂型方法

    公开(公告)号：US4743247A

    公开(公告)日：1988-05-10

    申请号：US846403

    申请日：1986-03-31

    申请人： Patrick S. Wong

    发明人： Patrick S. Wong

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： A device is disclosed with an internal space for receiving a beneficial agent. The device comprises a wall surrounding a compartment provided with an internal space and a hydrogel. A passageway in the wall connects the exterior of the device with the internal space. The passageway is used for filling the space with a beneficial agent, and then for dispensing the beneficial agent from the device.

    摘要翻译： 公开了一种具有用于接收有益代理的内部空间的装置。 该装置包括围绕设有内部空间和水凝胶的隔室的壁。 墙壁上的通道将设备的外部与内部空间连接起来。 通道用于用有益剂填充空间，然后从装置中分配有益剂。